Article
Pediatrics
Li Zhang, Nan-Nan Gao, Hui-Juan Liu, Qiong Wu, Ju Liu, Ting Zhang, Jin Sun, Jian-Hong Qi, Xiu-Yun Qiao, Yan Zhao, Yan Li
Summary: This retrospective cohort study in northern China formulated reference growth charts for a preterm cohort and found that the postnatal growth of these preterm infants was considerably higher than the internationally used IPPGS, especially for girls.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell Biology
Elena Layunta, Sofia Javerfelt, Brendan Dolan, Liisa Arike, Thaher Pelaseyed
Summary: The intestine is constantly exposed to chemicals, antigens, and microorganisms, but a glycocalyx forms an epithelial barrier preventing the entry of exogenous molecules and live bacteria into the brush-border membrane. Muc17 is identified as a major membrane mucin in the glycocalyx, upregulated by IL-22 during weaning to enhance the epithelial defense repertoire.
Article
Immunology
Ji-Eun Kim, Bo Li, Lijiang Fei, Rachael Home, Dorothy Lee, Adrian Kwan Loe, Hiromu Miyake, Eda Ayar, Dae-Kyum Kim, Michael G. Surette, Dana J. Philpott, Philip Sherman, Guoji Guo, Agostino Pierro, Tae-Hee Kim
Summary: This study found that early microbial exposure and disruption of this process can impact intestinal stem cell development, with impaired differentiation observed upon antibiotic treatment. Intestinal macrophages were found to secrete specific proteins that maintain the microenvironment crucial for stem cell differentiation. Antibiotic use and reduced numbers of Paneth cells were associated with the deadly disease necrotizing enterocolitis.
Article
Biochemistry & Molecular Biology
Felix Hofmann, Torsten Thalheim, Karen Rother, Marianne Quaas, Christiane Kerner, Jens Przybilla, Gabriela Aust, Joerg Galle
Summary: Intestinal cylindrical growth peaks in mice a few weeks after birth and stops after weaning. Cd97/Adgre5 transgenic mice show premature intestinal differentiation, leading to activation of intestinal epithelial cell growth and suppression of maturation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Guoxiu Wang, Qian Zhang, Zhanyu Chen, Yongliang Huang, Weimin Wang, Xiaoxue Zhang, Jiale Jia, Qihao Gao, Haoyu Xu, Chong Li
Summary: Although early feeding strategies have an impact on intestinal development, the influence of milk replacer feeding level on intestinal structure and functional development and the underlying regulatory mechanisms are still unclear. In this study, lambs were fed milk replacer at different levels and assessed for growth performance, feed intake, and intestinal functional development. The study identified differentially expressed genes and pathways involved in nutrient metabolism and coagulation cascades. Additionally, intensive milk replacer feeding affected insulin sensitivity, glucose absorption, and lipid and protein degradation in intestinal tissues through the regulation of specific genes.
Article
Biology
Abby Beatty, Alexander M. Rubin, Haruka Wada, Britt Heidinger, Wendy R. Hood, Tonia S. Schwartz
Summary: Calls for research on IGF2 in adult animals due to its important role in the insulin-like signalling network, which has been largely neglected in previous studies. Extensive survey and experimental evidence demonstrate the widespread presence of IGF2 in amniotes, often with higher relative expression than IGF1.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Miheret Yitayew, Nayef Chahin, Salem Rustom, Leroy R. Thacker, Karen D. Hendricks-Munoz
Summary: A study compared the performance of two growth-assessment tools, Fenton and Intergrowth-21st, in classifying size at birth, identifying growth failure, and predicting neurodevelopment in preterm infants. The results showed high agreement between the tools in identifying small for gestational age, but moderate agreement in classifying postnatal growth failure at discharge. Growth failure was less prevalent using IG-21st, and weight-based growth failure was significantly associated with poor neurodevelopmental outcomes at 12 and 24 months.
Review
Biochemistry & Molecular Biology
Shelby L. Oke, Daniel B. Hardy
Summary: Disruption of the in utero environment can have detrimental effects on fetal growth and development, leading to intrauterine growth restriction (IUGR) which affects birth weight and organ function. The developmental origins of health and disease (DOHaD) theory suggests that IUGR has long-term consequences on offspring health, with a negative correlation between birth weight and metabolic health. Animal studies have been crucial in elucidating the molecular mechanisms underlying these relationships, particularly the role of cellular stress in metabolic syndrome and programmed cell death in IUGR offspring's metabolic organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Quanquan Cao, Ju Zhao, Lingjie He, Tianran Zhang, Lin Feng, Weidan Jiang, Pei Wu, Juan Zhao, Haifeng Liu, Jun Jiang
Summary: This study evaluates the effects of dietary L-valine on the intestine of largemouth bass following a bacterial infection. The results indicate that optimal valine levels can improve growth performance, antioxidant capacity, and alleviate intestinal injury caused by the infection.
Article
Cell & Tissue Engineering
Takeshi Oichi, Joe Kodama, Kimberly Wilson, Hongying Tian, Yuka Imamura Kawasawa, Yu Usami, Yasushi Oshima, Taku Saito, Sakae Tanaka, Masahiro Iwamoto, Satoru Otsuru, Motomi Enomoto-Iwamoto
Summary: Long bone growth in the growth plate relies on endochondral ossification through the accumulation and synthesis of matrix scaffold by chondrocytes. Nutritional restriction increases the number of chondroprogenitors in the resting zone and inhibits their differentiation, while nutrient recovery promotes their differentiation and contributes to accelerated growth. Furthermore, the phosphorylation of Akt in the resting zone is reduced under nutrient deprivation, and exogenous IGF-1 restores the phosphorylation of Akt and stimulates the differentiation of chondroprogenitor cells, leading to a decrease in their numbers.
Article
Multidisciplinary Sciences
Yujung Michelle Lee, Andre Mu, Martina Wallace, Jivani M. Gengatharan, Annalee J. Furst, Lars Bode, Christian M. Metallo, Janelle S. Ayres
Summary: Maternal behavior is crucial for the optimal development and growth of offspring, while the intestinal microbiota plays a key role in regulating growth and development. Certain strains of Escherichia coli were found to be pathogenic to the maternal-offspring system, leading to growth stunting by interfering with maternal behavior rather than directly affecting the infants. This study provides new insights into how microbiota regulates postnatal growth and highlights an additional variable to consider when studying the regulation of maternal behavior.
Article
Pediatrics
Paul Kwong Hang Tam, Kenneth Kak Yuen Wong, Anthony Atala, Giovanni Giuseppe Giobbe, Claire Booth, Peter J. Gruber, Mimmi Monone, Shahin Rafii, Thomas A. Rando, Joseph Vacanti, Carly Comer, Nicola Elvassore, Tracy Grikscheit, Paolo de Coppi
Summary: Paper 2 of the paediatric regenerative medicine Series focuses on recent advances in postnatal approaches, including gene, cell, and niche-based technologies, providing new treatment options for pediatric diseases and common diseases affecting all ages.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Medicine, General & Internal
Honglin Jiang, Jialin Guo, Jing Li, Chunlin Li, Wenchong Du, Federico Canavese, Charlie Baker, Hao Ying, Jing Hua
Summary: This diagnostic study developed predictive models using an artificial neural network to identify neonates at risk for metabolic bone disease (MBD). Combining prenatal and postnatal factors or using postnatal exposures alone provided the most accurate prediction. Birth weight, maternal age at pregnancy, and neonatal disorders were important factors for predicting MBD risk.
Article
Nutrition & Dietetics
Rinawati Rohsiswatmo, Risma Kerina Kaban, Muhamad Azharry Rully Sjahrulla, Hardya Gustada Hikmahrachim, Putri Maharani Tristanita Marsubrin, Rosalina Dewi Roeslani, Adhi Teguh Perma Iskandar, Distyayu Sukarja, Ahmad Kautsar, Ivo Urwah
Summary: This study aimed to determine the indicators to define postnatal growth failure (PGF) among Indonesian preterm infants. The results showed that the decline in a weight-for-age z-score of ≥1.2 was useful in identifying PGF and also indicated the association with weight gain issues among subjects with PGF.
FRONTIERS IN NUTRITION
(2023)
Article
Neurosciences
Pankaj Patyal, Daniel Fil, Patricia A. Wight
Summary: Recently, the expression of the myelin proteolipid protein gene (Plp1) in the enteric nervous system (ENS) in mouse was studied, revealing limited knowledge about its expression in the intestine. This study investigated Plp1 expression in the intestine of mice at different ages, showing that Plp1 is predominantly expressed during early postnatal development as the DM20 isoform. The expression pattern of the 6.2hPLP(+)Z/FL transgene, which uses the human PLP1 gene to drive expression of a lacZ reporter gene, recapitulated the developmental pattern observed with the native gene, indicating its usefulness as a proxy for Plp1 gene expression.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
