Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qifeng Zhong, Yong Lu, Wenlong Xu, Zhien Rong, Xu Chang, Li Qin, Xiaoping Chen, Fang Zhou
Summary: NSCLC cells have a modulating effect on the protein expression of CD86 and HLA-DR on CD303(+) pDCs, as well as on the production of cytokines like IL-12, IL-23, IL-27, and TGF-beta by these cells. Additionally, NSCLC cells regulate the development of CD303(+) pDC subsets expressing CD205 and/or CD103 through the modulation of protein expression on these cells. This may ultimately contribute to the creation of an immune-suppressive microenvironment induced by NSCLC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Wei Zhang, Eun-Koung An, So-Jung Kim, Hae-Bin Park, Peter C. W. Lee, Jun-O Jin
Summary: This study demonstrated the side effects of FimH and indicated that the use of FimH can aggravate the disease in patients with colitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xuerun Liu, Luoyang Wang, Huiren Zhuang, Zhenghuan Yang, Guoqiang Jiang, Zheng Liu
Summary: Recent research has shown that anthocyanins have prebiotic attributes and can be used to treat microbiota-associated diseases. This study investigates the effects of bilberry anthocyanins on the gut microbiota composition, metabolism, and the intestinal mucosal immune system of mice. The findings suggest that oral administration of anthocyanins can help maintain intestinal homeostasis and may have applications in immunotherapy and related fields.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ranit Kedmi, Tariq A. Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yuhan Hao, Stephanie Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Joe Germino, Caleb A. Lareau, Ansuman T. Satpathy, Mark S. Anderson, Terri M. Laufer, Iannis Aifantis, Juliet M. Bartleson, Paul M. Allen, Helena Paidassi, James M. Gardner, Marlon Stoeckius, Dan R. Littman
Summary: The mutualistic relationship between gut-resident microbiota and the host immune system is crucial for maintaining homeostasis. Helicobacter species and other gut bacteria direct T cell differentiation through targeting specific antigen-presenting cells.
Article
Gastroenterology & Hepatology
Shuai Wang, Qinchuan Wu, Tianchi Chen, Rong Su, Caixu Pan, Junjie Qian, Hechen Huang, Shengyong Yin, Haiyang Xie, Lin Zhou, Shusen Zheng
Summary: In addition to the classical DC-T cell axis, CD47 blockade significantly enhances the ability of CD103(+) DCs to take up tumor DNA, resulting in the stimulation of the cGAS-STING pathway and the promotion of NK cell infiltration and activation in liver cancer.
JOURNAL OF HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Naoko Kanda, Toshihiko Hoashi, Hidehisa Saeki
Summary: Psoriasis is characterized by an imbalance in CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) and alterations in gut microbiota. Therapeutic agents targeting Tregs, such as anti-IL-23 or anti-IL-17A antibodies, retinoids, and probiotics/prebiotics, show promise in restoring Treg function and alleviating psoriasis symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Kaikai Zhao, Liyang Jiang, Youjiao Si, Shujie Zhou, Zhaoqin Huang, Xiangjiao Meng
Summary: This study explores the synergistic effects of radiotherapy (RT) combined with anti-TIGIT therapy and the underlying mechanism. The results show that TIGIT is upregulated in immune cells after RT. The administration of anti-TIGIT antibody enhances the efficacy of RT through a CD8+ T cell-dependent mechanism. The combination of RT and anti-TIGIT antibody promotes the accumulation of tumor-infiltrating dendritic cells (DCs), leading to the activation of CD8+ T cells. CD103+ DCs play a critical role in promoting the anti-tumor effects of the combination therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Hisashi Takeshita, Ryoji Yoshida, Junki Inoue, Kohei Ishikawa, Kosuke Shinohara, Mayumi Hirayama, Toru Oyama, Ryuta Kubo, Keisuke Yamana, Yuka Nagao, Shunsuke Gohara, Junki Sakata, Hikaru Nakashima, Yuichiro Matsuoka, Masafumi Nakamoto, Masatoshi Hirayama, Kenta Kawahara, Nozomu Takahashi, Akiyuki Hirosue, Yoshikazu Kuwahara, Manabu Fukumoto, Ryo Toya, Ryuji Murakami, Hideki Nakayama
Summary: Radioresistance is a major challenge in the treatment of oral squamous cell carcinoma (OSCC). In this study, we developed clinically relevant radioresistant (CRR) cell lines to investigate the regulation of radioresistance in OSCC cells. We found that the expression of FOXM1, a transcription factor, was upregulated in radioresistant cells compared to parental cells. Targeting FOXM1 showed potential as a therapeutic strategy to overcome radioresistance in OSCC.
LABORATORY INVESTIGATION
(2023)
Article
Immunology
Jens Wittner, Sebastian R. Schulz, Tobit D. Steinmetz, Johannes Berges, Manuela Hauke, William M. Channell, Adam F. Cunningham, Anja E. Hauser, Andreas Hutloff, Dirk Mielenz, Hans-Martin Jaeck, Wolfgang Schuh
Summary: Kruppel-like factor 2 (KLF2) plays a crucial role in lymphocyte differentiation and immune response, particularly in regulating the localization and function of IgA plasma cells.
MUCOSAL IMMUNOLOGY
(2022)
Article
Immunology
Javier Sanchez-Solares, Luis Sanchez, Carmela Pablo-Torres, Celso Diaz-Fernandez, Poul Sorensen, Domingo Barber, Cristina Gomez-Casado
Summary: The study found that CD patients have significantly decreased expression of epithelial junction proteins in their oral mucosa, suggesting compromised barrier integrity. The increase in FoxP3+ cells in CD patients indicates recruitment of Tregs to the damaged mucosa. Amphiregulin mRNA levels in PBMCs and epithelial damage in the oral mucosa correlated with Treg infiltration, suggesting a potential repair phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Lachlan M. Moldenhauer, Min Jin, Jasmine J. Wilson, Ella S. Green, David J. Sharkey, Mark D. Salkeld, Thomas C. Bristow, M. Louise Hull, Gustaaf A. Dekker, Sarah A. Robertson
Summary: Research has shown that oral contraception use can impact the number and phenotype of Treg cells, leading to physiological changes and altered disease susceptibility.
Review
Biochemistry & Molecular Biology
Laura Passeri, Fortunato Marta, Virginia Bassi, Silvia Gregori
Summary: Dendritic cells play a crucial role in autoimmune diseases by instructing T cells to respond to antigens, leading to organ damage or promoting immune tolerance. Research on different subsets of human DCs and the regulatory mechanisms associated with tolDC functions is ongoing, along with exploring tolDC-based therapies for treating autoimmune diseases. Continued expansion of research in the area of tolDCs will enhance understanding of the role of DCs in the development and treatment of autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiufang Cui, Ziping Ye, Di Wang, Yan Yang, ChunHua Jiao, Jingjing Ma, Nana Tang, Hongjie Zhang
Summary: This study found that activation of AhR in DCs can induce tolerogenic DCs, promote Treg cell differentiation, and alleviate the severity of intestinal inflammation. Transplanted tolDCs can also maintain the balance of Th17/Treg differentiation. Therefore, AhR may be a potential therapeutic target for CD.
CELL AND BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Hector F. Pelaez-Prestel, Jose L. Sanchez-Trincado, Esther M. Lafuente, Pedro A. Reche
Summary: The oral mucosa is a highly active site of immune activity where various immune cells play a crucial role in defending against pathogens. It is exposed to a variety of antigens from food and commensal bacteria that need to be tolerated, with mechanisms involving dendritic cells, regulatory T cells, and epithelial cells contributing to this tolerance. These tolerogenic mechanisms in the oral mucosa are intricately intertwined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)