Animal models of biliary tract injury

Ostα depletion protects liver from oral bile acid load

(2011) Carol J. Soroka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat

(2011) Matthew Quinn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fibrosis in Autoimmune and Cholestatic Liver Disease

(2011) Melitta Penz-Österreicher et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury

(2011) Tarek Moustafa et al.   GASTROENTEROLOGY

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

(2011) Salvatore Modica et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice

(2011) Chao Wang et al.   HEPATOLOGY

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

(2011) Andrew S. Chu et al.   HEPATOLOGY

Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice

(2011) Roja Barikbin et al.   HEPATOLOGY

Intestinal involvement during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury in a mouse model

(2011) Igor Sukhotnik et al.   JOURNAL OF PEDIATRIC SURGERY

Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver

(2011) Yuichi Yamazaki et al.   LABORATORY INVESTIGATION

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure

(2011) Hanno Ehlken et al.   PLoS One

Murine models of autoimmune cholangitis

(2010) Yoshiyuki Ueno et al.   CURRENT OPINION IN GASTROENTEROLOGY

Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice

(2010) David Scholten et al.   GASTROENTEROLOGY

Hedgehog signaling in the liver

(2010) Alessia Omenetti et al.   JOURNAL OF HEPATOLOGY

β-Adrenoceptor blockade in sclerosing cholangitis of Mdr2 knockout mice: antifibrotic effects in a model of nonsinusoidal fibrosis

(2010) Ingo Strack et al.   LABORATORY INVESTIGATION

Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation

(2010) Ikuko Haruta et al.   LABORATORY INVESTIGATION

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse organic solute transporter α deficiency enhances renal excretion of bile acids and attenuates cholestasis

(2009) Carol J. Soroka et al.   HEPATOLOGY

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

(2009) Kojiro Taura et al.   HEPATOLOGY

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis

(2008) Shelly Beer et al.   PLoS One