Journal
CURRENT OPINION IN GASTROENTEROLOGY
Volume 26, Issue 1, Pages 1-4Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0b013e328333d73b
Keywords
Campylobacter; colitis; Crohn's disease; Escherichia coli; inflammatory bowel disease; irritable bowel syndrome; O157:H7
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Funding
- Canada Research Chair in Gastrointestinal Disease
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Purpose of review The aim of this review is to highlight recent advances in knowledge of bacterial enteric infections. We focus on understanding of enterohemorrhagic Escherichia coli O157:H7 and Campylobacter jejuni infections, and to link these acute events with long-term consequences in a susceptible host, including irritable bowel syndrome and chronic inflammatory bowel diseases. Recent findings Enterohemorrhagic E coli and C. jejuni are zoonotic infections that are acquired from exposure to tainted food (undercooked hamburger and chicken, respectively) and contaminated drinking water. Noninvasive E coli O157:H7 elaborates Shiga-like toxins and protein effectors that are injected, via a molecular syringe that is encoded by a bacterial type 3 secretion system, into infected eukaryotic cells. Less is known about the precise virulence properties of enteroinvasive Campylobacter strains, but both enteric pathogens are able to disrupt polarized epithelial monolayers resulting in increased uptake of macromolecules and antigens. Summary An improved understanding of the epidemiology, pathobiology and mechanisms underlying infectious enterocoliticles will provide the basis for developing new intervention strategies including, for example, the use of probiotics, to interrupt the infectious process,
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