Article
Biochemistry & Molecular Biology
Matthew Thomas Ferreira, Juliano Andreoli Miyake, Renata Nascimento Gomes, Fabio Feitoza, Pollyana Bulgarelli Stevannato, Andrew Silva da Cunha, Fernanda de Oliveira Serachi, Alexandros Theodoros Panagopoulos, Alison Colquhoun
Summary: The study demonstrated the importance of PGE(2) signaling through the EP2 and EP4 receptors in controlling GBM cell biology, as well as a relationship between COX1 and MMP2 in these cells. These findings suggest a potential novel therapeutic target for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Physical
Lavanya Anumula, Sindhu Ramesh, Venkata Suneel Kumar Kolaparthi, Richard Kirubakaran, Mohmed Isaqali Karobari, Suraj Arora, Ahmed A. Saleh, Omir Aldowah, Pietro Messina, Giuseppe Alessandro Scardina
Summary: The present study aimed to systematically review the effects of natural cross-linkers on immediate and long-term tensile bond strength and concluded that Proanthocyanidin is the most efficient natural cross-linker to date, preserving bond strength even after ageing.
Article
Oncology
Yuka Ikeda, Kurumi Taniguchi, Haruka Sawamura, Sayuri Yoshikawa, Ai Tsuji, Satoru Matsuda
Summary: In this article, the invasiveness of cancer cells in relation to APRO family proteins is discussed. The role of matrix metalloproteinases (MMPs) and exosomes containing specific microRNAs in regulating cancer invasiveness is highlighted. Understanding these mechanisms can lead to innovative strategies for cancer therapy.
Article
Medicine, General & Internal
Tetsuji Morishita, Hiroyasu Uzui, Yusuke Sato, Yasuhiko Mitsuke, Hiroshi Tada
Summary: This study investigated the possible relationships between cachexia, metalloproteinases, and haemodynamics in chronic heart failure patients in Japan, the most aged country in the world. The results showed that cachexia was associated with adverse outcomes and increased activity of MMP species and PVR in this population. Cachexia was also found to be an independent predictor of mortality, with specific biomarkers identified as predictors of cardiac cachexia.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Narges Hosseini Nasab, Fereshteh Azimian, Rok Su Shim, Young Seok Eom, Fahad Hassan Shah, Song Ja Kim
Summary: The synthesis of eleven new thiazolyl-pyrazoline derivatives and their in-vitro anti-proliferative activities against human lung carcinoma and human melanoma cancer cell lines were evaluated. Four compounds were identified as the most active against both cell lines, especially compound 7k. These compounds also exhibited anti-metastasis and anti-inflammatory properties.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Chemical
Deborah Cavalcante Magalhaes Rolim, Lidiane Costa Souza, Viviane Hass, Paulo Goberlanio Barros Silva, Cacia Signori, Maximiliano Sergio Cenci, Juliana Lays Stolfo Uehara, Vicente de Paulo Aragao Saboia
Summary: This study investigated the effect of incorporating two cross-linkers agents into adhesive systems with a self-etch approach on dentin. The results showed that the cross-linkers did not have a significant advantage in different time points and substrate conditions. When using the self-etch approach, the adhesive system CSE showed higher bond strength, and sound dentin had higher bond strength compared to caries affected dentin.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2022)
Article
Medicine, Research & Experimental
Xiwu Ouyang, Lemeng Feng, Lei Yao, Yao Xiao, Xianyu Hu, Gewen Zhang, Guodong Liu, Zhiming Wang
Summary: The study highlights the oncogenic role of TR4 in the development of papillary thyroid cancer (PTC), driving PTC progression by promoting cell invasion and migration. The TR4/circFLNA/miR-149-5p/MMP9 signaling axis plays a central role in cell invasion and migration of PTC cells, suggesting that targeting this pathway may be an alternative option for metastatic PTC patients.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Chemistry, Analytical
Xintong Lu, Luoyu Ding, Haohan Song, Wenxin Yu, Chaoqing Dong, Jicun Ren
Summary: A novel in situ single molecule spectroscopy method based on fluorescent correlation spectroscopy (FCS) technique was proposed for measuring MMP-9 activity in single living cells. The method utilizes a fluorescent specific peptide and a reference dye as dual probes, and ratiometric translational diffusion time as the measurement parameter.
Article
Cardiac & Cardiovascular Systems
Kelly M. Stanton, Hongjuan Liu, Vivian Kienzle, Christina Bursill, Shisan Bao, David S. Celermajer
Summary: Exercise for 10 weeks reduced atherosclerotic plaque stenosis and improved lipid profiles in apolipoprotein E-/- mice, with more significant effects observed when exercise commenced at earlier stages of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kenneth K. Wu
Summary: 5-MTP inhibits cancer cell proliferation and invasion by suppressing COX-2 and MMP-9 expression. Its anti-cancer effect is mediated through blocking p38 MAPK and p38-mediated NF-kappa B and p300 HAT activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Ying Shi, Xiaochuan Ma, Ge Fang, Xin Tian, Cuicui Ge
Summary: Matrix metalloproteinases play a crucial role in tumor invasion and metastasis, making MMP inhibitors an attractive therapeutic target. However, achieving specificity in MMPI development remains a challenge, leading to limited clinical application and potential biosafety risks. Nanomaterials offer a promising alternative for MMPI design, with strategies for screening, designing, and discussing the future prospects and challenges in therapeutic applications.
Article
Dentistry, Oral Surgery & Medicine
Leticia Cabrera Capalbo, Alberto Carlos Botazzo Delbem, Renan Dal-Fabbro, Kelly Karina Inacio, Rodrigo Cardoso de Oliveira, Juliano Pelim Pessan
Summary: This study investigated the ability of solutions containing sodium hexametaphosphate, fluoride, and quercetin to prevent dentin erosion and inhibit matrix metalloproteinases-2 and -9 activity. The results showed that the combination of fluoride, sodium hexametaphosphate, and quercetin had superior protective effects against dentin erosion and antiproteolytic potential.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Alessia Caradonna, Mariangela Agamennone, Fulvio Loiodice, Paolo Tortorella
Summary: Matrix metalloproteinases (MMPs) play a crucial role in physiological tissue remodeling but overexpression of certain MMPs, associated with pathological conditions like cancer and metastasis, has led to exploration of MMP inhibitors (MMPIs) as a strategy to hinder metastasis. However, the clinical use of MMPIs has been limited by side effects, prompting the development of strategies to improve therapeutic profile and targeting specificity.
