Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 13, Issue 2, Pages 139-144Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e3283357287
Keywords
cardiovascular disease; fatty acids; nutrient-gene interactions
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Funding
- NHLBI NIH HHS [HL54776, R01 HL054776-12, R01 HL054776] Funding Source: Medline
- NIA NIH HHS [5P01AG023394, P01 AG023394] Funding Source: Medline
- NIDDK NIH HHS [DK075030, T32 DK007651-19, T32 DK007651, R01 DK075030-03, R01 DK075030] Funding Source: Medline
- NIMHD NIH HHS [L60 MD003562] Funding Source: Medline
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Purpose of review The number of studies investigating interactions between genes and nutrients for cardiovascular disease continues to grow, and holds tremendous potential for reducing disease risk at the level of the individual genotype. However, understanding the limitations and challenges of interaction studies, whether of observational or interventional design, is essential for critical evaluation of these studies. Recent findings Nutrient-gene interactions for cardiovascular disease both parallel and extend nutrition studies, encompassing both traditional and novel cardiovascular risk factors. Fatty acid quality, lipid metabolism, inflammation, postprandial metabolism, fatty liver and macronutrient-gene interactions for obesity and metabolic syndrome represent a subset of the major areas of recent focus. With few exceptions, however, studies of gene-nutrient interactions are limited to a single population. Summary Gene-nutrient research will continue to expand as genome-wide association studies uncover new sources of genetic variability associated with cardiovascular risk. However, in addition to investigation of newly discovered variants, continuing efforts must focus on the confirmation of previously reported genetic associations and interactions in additional populations.
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