Article
Nutrition & Dietetics
Alicja Kolodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Summary: A study was conducted to assess the effectiveness of monitored vitamin D supplementation in preterm infants. Results showed that a higher percentage of infants in the monitored group had safe vitamin D levels, while potential vitamin D toxicity was observed in the standard treatment group. Therefore, vitamin D intake should be between 800-1000 IU and monitored to avoid overdose.
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Biochemistry & Molecular Biology
Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki
Summary: Vitamin D and VDR play critical roles in maintaining calcium homeostasis, bone formation, and immune response against cancer. Mutations in the VDR gene are associated with manifestations of type II rickets and abnormal bone formation. The unliganded VDR is crucial for maintaining the hair cycle and normal skin.
Article
Pediatrics
Noah P. Diminick, Jamie M. Fey, Jonathan Bourque, Patricia Crosby, Leah Fox, Diana Tsai-Leonard, Heidi Morin, Kathleen Cyr, William Hewitt, Lorraine L. McElwain
Summary: This interdisciplinary quality improvement effort aimed to increase the proportion of reported appropriate vitamin D supplementation for infants born at the institution and those who followed up in the resident clinic. Bedside medication delivery and education in the newborn nursery proved to improve reported vitamin D supplementation rates in the first 6 months of life.
Review
Nutrition & Dietetics
Alberto Caballero-Garcia, Alfredo Cordova-Martinez, Nestor Vicente-Salar, Enrique Roche, Daniel Perez-Valdecantos
Summary: Vitamin D plays a crucial role in immune modulation, enhancing macrophage functions and modulating muscle inflammatory response and protein synthesis. It is particularly important in cases of deficiency or high muscular demand.
Article
Immunology
Fatima A. H. Al-Jaberi, Cornelia Geisler Crone, Thomas Lindenstrom, Nicolai Skovbjerg Arildsen, Emilia Saederup Lindelov, Louise Aagaard, Eva Gravesen, Rasmus Mortensen, Aase Bengaard Andersen, Klaus Olgaard, Jessica Xin Hjaltelin, Soren Brunak, Charlotte Menne Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Tuberculosis is a serious health issue affecting a significant portion of the global population, with a quarter being infected with Mycobacterium tuberculosis. Vitamin D plays a crucial role in the immune response against M. tuberculosis, but research is hindered by a lack of suitable experimental models. Studying families with hereditary vitamin D-resistant rickets (HVDRR) provides unique insights into the immunoregulatory effects of vitamin D. A case study of an HVDRR patient with impaired cathelicidin production highlights the importance of vitamin D in combating M. tuberculosis pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Rosalyn J. Singleton, Gretchen M. Day, Timothy K. Thomas, Joseph A. Klejka, Christine A. Desnoyers, Melanie N. P. McIntyre, David M. Compton, Kenneth E. Thummel, Robert J. Schroth, Leanne M. Ward, Dane C. Lenaker, Rachel K. Lescher, Joseph B. McLaughlin
Summary: The study found that prenatal vitamin D supplementation in high-risk populations can improve childhood outcomes regarding rickets and dental caries.
Article
Multidisciplinary Sciences
Girma Teferi Mengistu, Ayana Benti Terefe, Tolesa Gemeda Gudeta, Bizunesh Kefale Mengistu
Summary: This study investigated the practice of infant sunlight exposure among mothers in Ethiopia and found that 67.3% of mothers had good practice. Factors affecting mothers' practice included age and place of residence.
Review
Nutrition & Dietetics
Andreea Bianca Stoica, Claudiu Marginean
Summary: This article reviews the impact of vitamin D deficiency on the health of infants, emphasizing its global significance and the need for further research and strategies. While conflicting results exist regarding the effects of vitamin D, it is clear that deficiency has significant implications, particularly for infants.
Review
Biochemistry & Molecular Biology
Oscar D. Pons-Belda, M. Agustina Alonso-Alvarez, Juan David Gonzalez-Rodriguez, Laura Mantecon-Fernandez, Fernando Santos-Rodriguez
Summary: FGF23 was identified as circulating phosphatonin in human pathology and plays a pathogenic role in various diseases. However, its metabolism in children is largely unknown. This review focuses on the metabolism of FGF23 in pediatric age and its relationship with vitamin D metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Ahmad Azam Malik, Mukhtiar Baig, Nadeem Shafique Butt, Muhammad Imran, Sami Hamdan Alzahrani, Zohair Jamil Gazzaz
Summary: This study evaluated the trends and performance of Vitamin D and bone metabolism-related publications. The findings showed that the USA, Japan, China, and the United Kingdom had the highest number of published articles, while Cooper C, Dawson-Hughes B, and Holick MF were the most prolific authors. The study also revealed a decline in contributions from the most prominent sources.
Article
Biochemistry & Molecular Biology
Fabienne Jaun, Maria Boesing, Giorgia Luethi-Corridori, Kristin Abig, Nando Bloch, Stephanie Giezendanner, Victoria Grillmayr, Philippe Haas, Anne B. Leuppi-Taegtmeyer, Juergen Muser, Andrea Raess, Philipp Schuetz, Michael Brandle, Joerg D. Leuppi
Summary: The role of vitamin D in the COVID-19 pandemic has been controversial, and the effectiveness of vitamin D-3 supplementation in COVID-19 patients remains inconclusive. This study conducted a randomized, placebo-controlled double-blind trial on hospitalized COVID-19 patients to compare the effect of high-dose vitamin D-3 supplementation on length of hospital stay. The results showed that vitamin D-3 supplementation did not significantly shorten the hospital stay.
Article
Biochemistry & Molecular Biology
Philip R. Fischer, Neamat Almasri
Summary: Nutritional rickets can be caused by either vitamin D deficiency or insufficient dietary intake of calcium, and the combined deficiencies of calcium and vitamin D interact. Other factors also play a role in the pathogenesis of nutritional rickets.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Pediatrics
Sophie Jullien
Summary: Vitamin D supplementation is effective in improving bone health and preventing rickets, especially in high-risk groups. A daily dose of 400 international units of vitamin D is strongly recommended during infancy. Beyond infancy, supplementation should be targeted at children in risk groups to avoid potential toxicity from higher doses.
Review
Nutrition & Dietetics
Dov Tiosano, Steven A. Abrams, Yoseph Weisman
Summary: Lessons learned from HVDRR patients with dysfunctional VDR include the impact on bone health during childhood, recovery after puberty, unique responses in immune function, and protection against asthma despite vitamin D deficiency. The role of VDR in various human systems, such as the renin angiotensin system and reproductive health, remains important for further study using HVDRR patients as a unique model.
JOURNAL OF NUTRITION
(2021)