Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 17, Issue 4, Pages 663-671Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2013.04.027
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM092930] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM092930] Funding Source: Medline
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Diffusion barriers are universal solutions for cells to achieve distinct organizations, compositions, and activities within a limited space. The influence of diffusion barriers on the spatiotemporal dynamics of signaling molecules often determines cellular physiology and functions. Over the years, the passive permeability barriers in various subcellular locales have been characterized using elaborate analytical techniques. In this review, we will summarize the current state of knowledge on the various passive permeability barriers present in mammalian cells. We will conclude with a description of several conventional techniques and one new approach based on chemically inducible diffusion trap (CIDT) for probing permeable barriers.
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