Article
Medicine, General & Internal
Amalia Ioanna Moula, Iris Parrini, Cecilia Tetta, Fabiana Luca, Gianmarco Parise, Carmelo Massimiliano Rao, Emanuela Mauro, Orlando Parise, Francesco Matteucci, Michele Massimo Gulizia, Mark La Meir, Sandro Gelsomino
Summary: Atrial fibrillation (AF) is the most common arrhythmia, with its incidence increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a chronic sleep disorder more commonly found in older men. Previous studies have shown a link between OSA and AF, although the prevalence of OSA in AF patients remains unknown due to underdiagnosis. This meta-analysis investigated the association between OSA and AF, using data from 54,271 patients. A strong link was found between these two disorders, with the incidence of AF being 88% higher in patients with OSA. Age and hypertension were found to independently strengthen this association, indicating that treating OSA may help reduce AF recurrence. Further research is needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ahmed Dalmar, Maharaj Singh, Zoe Heis, Tabitha L. Cumpian, Cheryl Ceretto, M. Eyman Mortada, Atul Bhatia, Imran Niazi, Thomas Y. Chua, Jasbir Sra, Arshad Jahangir
Summary: Weight loss in morbidly obese patients can reduce AF, but it is unclear whether similar benefits are achieved in patients with OSA. This study found that despite similar weight loss, patients with OSA had a higher incidence of new-onset AF and stroke, with OSA, age, and hypertension being independent predictors of AF, and OSA, depression, and BMI being predictors for stroke events. Both non-AF and AF-related factors contribute to increased stroke risk, and further investigation is needed to determine if OSA treatment can help reduce AF or stroke events in this population.
Article
Cardiac & Cardiovascular Systems
Michiel Delesie, Lieselotte Knaepen, Johan Verbraecken, Karolien Weytjens, Paul Dendale, Hein Heidbuchel, Lien Desteghe
Summary: This study demonstrates that home-worn PGs with an automated AHI algorithm can serve as OSA screening tools in AF patients. Different devices showed varying success rates in home monitoring, but all performed well in detecting clinically relevant OSA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Raquel Lopez-Galvez, Jose Miguel Rivera-Caravaca, Dario Mandaglio-Collados, Esteban Orenes-Pinero, Alvaro Lahoz, Diana Hernandez-Romero, Carlos M. M. Martinez, Marina Carpes, Jose Maria Arribas, Sergio Canovas, Gregory Y. H. Lip, Francisco Marin
Summary: Obstructive sleep apnea (OSA) promotes atrial remodeling and fibrosis, providing a substrate for atrial fibrillation (AF). In this study, the pathophysiological mechanisms of AF in patients with OSA were investigated. Biomarkers reflective of AF pathophysiology and miRNAs involved in AF were assessed. OSA patients exhibited a higher incidence of postoperative AF, dysregulated biomarkers and miRNAs, and increased interstitial fibrosis, all of which contribute to the development of a substrate that increases the AF risk.
Article
Multidisciplinary Sciences
Jiasuoer Xiaokereti, Yan-Kai Guo, Zhen-Yu Dong, Mei Ma, Yan-Mei Lu, Yao-Dong Li, Xian-Hui Zhou, Ling Zhang, Bao-Peng Tang
Summary: Autonomic imbalance in obstructive sleep apnea plays a crucial role in atrial fibrillation. The study found that OSA significantly enhanced neural remodeling in the left stellate ganglion and left atrium, leading to increased AF inducibility.
Article
Clinical Neurology
Patrick L. Stafford, Evan Harmon, Paras Patel, McCall Walker, Nazem Akoum, Seung-Jung Park, Yeilim Cho, Kenneth Bilchick, Nishaki Mehta, Sula Mazimba, Yoonsik Cho, Younghoon Kwon
Summary: This study investigated the prevalence and associated factors of positional obstructive sleep apnea (POSA) in patients with atrial fibrillation (AF). The results showed that POSA prevalence was similar between patients with and without AF. Obesity and severe OSA were associated with lower odds of POSA, while male sex was associated with higher odds of POSA in patients with AF.
SLEEP AND BREATHING
(2023)
Article
Geriatrics & Gerontology
Huanhuan Wang, JianHua Li, Yinghui Gao, Kaibing Chen, Yan Gao, JingJing Guo, Min Shi, Xiao Zou, Weihao Xu, LiBo Zhao, Xiaofeng Su, Yabin Wang, Juan Liu, Hu Xu, Xiaoxuan Kong, Junling Lin, Xiaoshun Qian, Jiming Han, Lin Liu
Summary: This study aimed to identify the prevalence and factors associated with atrial fibrillation (AF) in older patients with obstructive sleep apnea (OSA) in China. The results showed that the prevalence of AF significantly increased with age and was independently related to factors such as drinking history, chronic heart disease, diabetes mellitus, and reduced diastolic function among patients with OSA.
Article
Nutrition & Dietetics
Kazuki Shiina, Yoshifumi Takata, Takamichi Takahashi, Junya Kani, Hiroki Nakano, Yasuyuki Takada, Yoshinao Yazaki, Kazuhiro Satomi, Hirofumi Tomiyama
Summary: The prevalence of atrial fibrillation (AF) is higher in patients with obstructive sleep apnea (OSA) compared to those without AF. This study aimed to determine the prevalence and factors associated with AF in OSA patients from a large Japanese sleep cohort. The results showed that age, a history of alcohol consumption, undernutrition, and reduced sleep quality were independent risk factors for AF presence in OSA patients.
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Cardiac & Cardiovascular Systems
Bing Huang, Huafen Liu, Benjamin J. Scherlag, Lihua Sun, Shifeng Xing, Jie Xu, Mei Luo, Yankai Guo, Guiqiu Cao, Hong Jiang
Summary: Obstructive sleep apnea is a risk factor for atrial fibrillation and may reduce the effectiveness of traditional treatments. Continuous positive airway pressure therapy may have low compliance in OSA patients. Autonomic activation has been shown to play a role in the pathogenesis of AF in OSA, suggesting potential for autonomic modulation as a therapeutic target.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Valerio Brunetti, Elisa Testani, Anna Losurdo, Catello Vollono, Aldobrando Broccolini, Riccardo Di Iorio, Giovanni Frisullo, Fabio Pilato, Paolo Profice, Jessica Marotta, Eleonora Rollo, Irene Scala, Paolo Calabresi, Giacomo Della Marca
Summary: This study aimed to evaluate the association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) in acute ischemic stroke. The results showed that OSA and AF are highly prevalent but not associated in acute stroke. Furthermore, OSA acts as an independent risk factor for stroke.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Anna Hojager, Mikkel M. Schoos, Peter K. Tingsgaard, Troels G. Bock, Preben Homoe
Summary: The prevalence of silent atrial fibrillation (AF) and its associated risk factors were investigated in patients with obstructive sleep apnea (OSA). Among 238 patients with moderate and severe OSA, 8.8% were diagnosed with AF. The majority of patients had coexisting hypertension and dyslipidemia.
Article
Cardiac & Cardiovascular Systems
Weiqi Chen, Xueli Cai, Hongyi Yan, Yuesong Pan
Summary: Using Mendelian randomization, this study found that genetically predicted OSA has a causal effect on an increased risk of atrial fibrillation. The results were consistent across various sensitivity analyses.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Yung-Lung Chen, Yung-Che Chen, Ya-Ting Chang, Hui-Ting Wang, Wen-Hao Liu, Shaur-Zheng Chong, Pei-Ting Lin, Po-Yuan Hsu, Mao-Chang Su, Meng-Chih Lin
Summary: This study found that diabetes mellitus, lower sleep efficiency, lower left ventricular ejection fraction, and larger left atrial size were independent predictors of atrial fibrillation (AF) occurrence in obstructive sleep apnea syndrome (OSAS) patients. A left atrial size of >= 38.5 mm can predict AF occurrence in OSAS patients. In OSAS patients during non-rapid eye movement, the apnea-hypopnea index and oxygen desaturation index were negatively correlated with GJA1 expression.
Article
Clinical Neurology
Chou-Han Lin, Maria Timofeeva, Tara O'Brien, Owen D. Lyons
Summary: The study aimed to investigate the impact of OSA on the time of onset of symptomatic AF episodes. The results showed that patients with OSA were more likely to have AF attacks during sleeping hours compared to those with mild or no OSA. This suggests a causal role of OSA in the pathogenesis of AF in this population. The findings suggest that patients with nocturnal AF attacks should be evaluated for OSA.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
