4.1 Review

Combination therapy for dyslipidemia

Journal

CURRENT OPINION IN CARDIOLOGY
Volume 26, Issue 5, Pages 420-423

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HCO.0b013e3283499ef1

Keywords

combination therapy; dyslipidemia; ezetimibe; fenofibrate; niacin

Ask authors/readers for more resources

Purpose of review Residual cardiovascular risk remains in individuals treated with statins and combination therapies may reduce this risk further. Recent findings Most previous trials of combination therapies have shown a favorable effect on lipid profiles without clinical superiority over statin monotherapy. Trial design has been hampered by short duration and comparison with a low dose statin. The Study of Heart and Renal Protection trial has recently reported findings and shows a benefit of ezetimibe/simvastatin over simvastatin alone. AIM-HIGH (Atherothrombosis Intervention in Metabolic syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes), a trial of statin/niacin, has been prematurely halted for futility. Finally, combining a statin with both niacin and ezetimibe shows significant enhancement of the therapeutic effect on lipid profiles. Summary Current evidence continues to support initiation of a potent statin with titration to achieve targets. Combinations may be useful in individuals unable to reach desired lipid levels on maximal tolerated doses of statins.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.1
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available