Article
Cardiac & Cardiovascular Systems
Amadeo-Jose Wals-Rodriguez, Maria-Jose Rodriguez-Puras, Rocio Garcia-Orta, Juan Robledo, Eduardo Moreno, Carmen Federero, Rocio Camacho, Begona Manso, Nuria Hernandez, Jose Maria Cubero, Raquel Ladron Abia, Pilar Cejudo Ramos, Antonio Ordonez, Pastora Gallego
Summary: The study found that the survival rate of adults with PAH-CHD receiving vasodilator treatment was 65%, with the highest mortality rate in the pre-tricuspid group. Older age was associated with higher risk of death, and predictors of poor outcome included pericardial effusion, oxygen saturation, and genetic syndromes.
Article
Medicine, General & Internal
Susanne J. Maurer, Veronika Habdank, Juergen Horer, Peter Ewert, Oktay Tutarel
Summary: This study aimed to investigate the risk factors for poor outcome in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD). The results showed that NT-proBNP is an independent predictor of all-cause mortality in PAH-CHD patients. The role of CRP and uric acid should be further studied.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Ting Wang, Yue Xing, Bingming Peng, Kai Yang, Chenting Zhang, Yuqin Chen, Gang Geng, Qubei Li, Jian Fu, Mi Li, Zhengxiu Luo, Zhou Fu, Jian Wang
Summary: This study systematically defines and compares the upper respiratory tract microbiota in pediatric PH patients, CHD and reference subjects, as well as the differences between pediatric and adult PH patients.
Article
Cardiac & Cardiovascular Systems
Shuenn-Nan Chiu, Chun-Wei Lu, Ming-Tai Lin, Chun-An Chen, Mei-Hwan Wu, Jou-Kou Wang
Summary: This study investigates the clinical characteristics of pulmonary hypertension (PH) in adult congenital heart disease (CHD) patients in Taiwan, with a focus on complex CHD. The cumulative incidence of PH in this Asian cohort was similar to that in Western countries. Patients with PH had higher mortality rates, but survival rates were similar across different CHD subtypes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew Constantine, Konstantinos Dimopoulos, Petra Jenkins, Robert M. R. Tulloh, Robin Condliffe, Katrijn Jansen, Natali A. Y. Chung, James Oliver, Helen Parry, Samantha Fitzsimmons, Niki Walker, Stephen John Wort, Vasilios Papaioannou, Kate von Klemperer, Paul Clift
Summary: The Fontan circulation is a surgical strategy for treating congenital heart disease with single ventricle physiology, and Fontan failure is a major cause of poor quality of life and mortality. This study assessed the use of PAH therapies in adult patients with Fontan physiology in specialist centers in the United Kingdom, targeting individuals with more advanced disease or complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Qian Zhang, Fang Zhu, Guocheng Shi, Chen Hu, Weituo Zhang, Puzhen Huang, Chunfeng Zhu, Hong Gu, Dong Yang, Qiangqiang Li, Yonghua Niu, Hao Chen, Ruixiang Ma, Ziyi Pan, Huixian Miao, Xin Zhang, Genxia Li, Yabing Tang, Guyuan Qiao, Yichen Yan, Zhongqun Zhu, Hao Zhang, Fengzhen Han, Yanna Li, Jianhua Lin, Huiwen Chen
Summary: This study evaluated the pregnancy outcomes in women with congenital heart disease (CHD) with and without pulmonary hypertension (PH). The results showed that women with CHD-associated mild PH had better pregnancy outcomes compared to those with moderate-to-severe PH, with similar outcomes to women with CHD and no PH.
Article
Cell Biology
Jing-jing Zhou, Huang Li, Li Li, Yue Li, Pei-he Wang, Xian-min Meng, Jian-guo He
Summary: Research has shown that CYLD plays a crucial role in the development of CHD-PAH by modulating HPASMC dysfunction and inflammation, thus influencing the progression of PAH. Inhibiting CYLD expression can attenuate PAH levels in rats and prevent pulmonary vascular remodeling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Amalia Baroutidou, Alexandra Arvanitaki, Adam Hatzidakis, Georgia Pitsiou, Antonios Ziakas, Haralambos Karvounis, George Giannakoulas
Summary: Haemoptysis is a severe bleeding manifestation in the clinical course of pulmonary arterial hypertension associated with congenital heart disease. Dysfunction of the pulmonary vascular bed increases the risk of haemoptysis episodes, and despite treatment strategies like BAE, bleeding recurrences are prevalent. There is currently no clear guideline regarding the use of oral anticoagulation in patients with haemoptysis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Peripheral Vascular Disease
Katherine B. Salciccioli, Justin P. Zachariah
Summary: Coarctation of the aorta carries an increased risk of hypertension, both before and after repair. This review aims to describe the management of coarctation of the aorta at all ages, highlight pathophysiologic mechanisms of hypertension, and discuss considerations for long-term follow-up.
Review
Cardiac & Cardiovascular Systems
Maolin Zhao, Jian Liu, Mei Xin, Ke Yang, Honghao Huang, Wenxin Zhang, Jinbao Zhang, Siyi He
Summary: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a progressive condition with uncertain physiological course. Omics technology, such as genomics, transcriptomics, epigenomics, proteomics, metabolomics, and multi-omics integration, has provided advanced techniques for comprehensive assessment of the disease and identification of treatment strategies. Recent research has made significant progress in understanding PAH-CHD through the application of omics approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Abdulaziz Al-Khaldi, Ahmad D. Abuzaid, Omar Tamimi, Atif Alsahari, Abdulmajeed Alotay, Tarek Momenah, Juan J. Alfonso
Summary: This study retrospectively analyzed the late outcomes of peripheral pulmonary artery reconstruction in 91 patients. The results showed excellent and durable late outcomes, with significant reductions in right ventricular to aortic systolic pressure ratio and low mortality rates. No reinterventions were necessary.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Medicine, General & Internal
Katharina Meinel, Martin Koestenberger, Hannes Sallmon, Georg Hansmann, Guido E. Pieles
Summary: Invasive assessment in the catheterization laboratory is the gold standard for diagnosing pulmonary hypertension in children, but transthoracic echocardiography (TTE) is the initial diagnostic tool. Guidelines suggest key echocardiographic variables for screening, but these may not apply to patients with congenital heart disease (CHD). Misinterpretation of TTE variables can lead to delayed diagnosis and therapy, or unnecessary invasive procedures with risks in the pediatric age group.
Article
Cardiac & Cardiovascular Systems
Ayako Chida-Nagai, Naoki Masaki, Kay Maeda, Konosuke Sasaki, Hiroki Sato, Jun Muneuchi, Yoshie Ochiai, Hiroomi Murayama, Masahiro Tahara, Atsuko Shiono, Atsushi Shinozuka, Fumihiko Kono, Daisuke Machida, Shinichi Toyooka, Seiichiro Sugimoto, Kazufumi Nakamura, Satoshi Akagi, Maiko Kondo, Shingo Kasahara, Yasuhiro Kotani, Junichi Koizumi, Katsuhiko Oda, Masako Harada, Daisuke Nakajima, Akira Murata, Hazumu Nagata, Koichi Yatsunami, Tomio Kobayashi, Yoshikiyo Matsunaga, Takahiro Inoue, Hiroyuki Yamagishi, Naomi Nakagawa, Katsuki Ohtani, Masaki Yamamoto, Yushi Ito, Tatsunori Hokosaki, Yuta Kuwahara, Satoshi Masutani, Koji Nomura, Tsutomu Wada, Hirofumi Sawada, Masayuki Abiko, Tatsunori Takahashi, Yuichi Ishikawa, Seigo Okada, Atsushi Naitoh, Takako Toda, Tatsuya Ando, Akihiro Masuzawa, Shinsuke Hoshino, Masaaki Kawada, Yuichi Nomura, Kentaro Ueno, Naoki Ohashi, Tsuyoshi Tachibana, Yuchen Cao, Hideaki Ueda, Sadamitsu Yanagi, Masaaki Koide, Norie Mitsushita, Kouji Higashi, Yoshihiro Minosaki, Tomohiro Hayashi, Takashi Okamoto, Kenji Kuraishi, Eiji Ehara, Hidekazu Ishida, Hitoshi Horigome, Takashi Murakami, Kohta Takei, Taku Ishii, Gen Harada, Yasutaka Hirata, Jun Maeda, Shunsuke Tatebe, Chiharu Ota, Yasunobu Hayabuchi, Hisanori Sakazaki, Takashi Sasaki, Keiichi Hirono, Sayo Suzuki, Masahiro Yasuda, Atsuhito Takeda, Madoka Sawai, Kagami Miyaji, Atsushi Kitagawa, Yosuke Nakai, Nobuyuki Kakimoto, Kouta Agematsu, Atsushi Manabe, Yoshikatsu Saiki
Summary: The IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jun Luo, Yuanchang Li, Jingyuan Chen, Haihua Qiu, Wenjie Chen, Xiaoqin Luo, Yusi Chen, Yingjie Tan, Jiang Li
Summary: This study found a relationship between serum uric acid level and the severity of disease and treatment response in patients with PAH-CHD. Serum uric acid can be used as a biomarker for risk stratification and evaluation of treatment effects for PAH-CHD patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liukun Meng, Wen Yuan, Hongjie Chi, Ruijuan Han, Yeping Zhang, Xiangbin Pan, Jian Meng, Ying Liu, Jiawei Song, Jiuchang Zhong, Xiaoyan Liu
Summary: This study revealed a significant role of CMG2 in the pathogenesis of SPS-induced PAH, where CMG2 deficiency exacerbates vascular remodeling, suggesting CMG2 as a potential target for the treatment of CHD-PAH.
Article
Cardiac & Cardiovascular Systems
Ioannis T. Farmakis, George Giannakoulas
HEART FAILURE CLINICS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Stephan Rosenkranz, Marion Delcroix, George Giannakoulas, Marius M. Hoeper, Gabor Kovacs, Marc Humbert
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Dimitrios V. Moysidis, Anastasios Kartas, Athanasios Samaras, Andreas S. Papazoglou, Vasiliki Patsiou, Alexandra Bekiaridou, Amalia Baroutidou, Christos Tsagkaris, Efstratios Karagiannidis, Stylianos Daios, Vasileios Anastasiou, Dimitrios Tsalikakis, Georgios Efthimiadis, Antonios Ziakas, Apostolos Tzikas, George Giannakoulas
Summary: In patients with heart failure and atrial fibrillation, the use of evidence-based target doses of RAAS inhibitors and beta-blockers is often underused in real-world conditions. A retrospective cohort study found that only 30.7% of patients received target doses of guideline-directed medical treatment (GDMT) medications at 3 months after discharge. Patients with lower eGFR levels had a lower proportion of optimally targeted GDMT achievement. Nontargeted GDMT was associated with a higher risk of mortality and cardiovascular events.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Ioannis Milioglou, Ioannis Farmakis, Mohannad Wazirali, Steven Ajluni, Tasveer Khawaja, Abhishek Chatuverdi, George Giannakoulas, Mehdi Shishehbor, Jun Li
Summary: Catheter-directed interventions, particularly percutaneous thrombectomy (PT), have shown efficacy and safety in treating pulmonary embolism (PE) patients with contraindications to thrombolysis. This systematic review and meta-analysis included 17 studies with 455 patients and found a mortality rate of 4% in hospital and 5% at 30 days. The procedure resulted in reductions in pulmonary pressures and improved hemodynamic and radiographic parameters. Major bleeding events occurred in 4% of patients. This study highlights the potential of PT as a valuable treatment for PE patients unable to receive thrombolytic therapy.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Medicine, General & Internal
Athanasios Samaras, Alexandra Bekiaridou, Andreas S. Papazoglou, Dimitrios Moysidis, Grigorios Tsoumakas, Panagiotis Bamidis, Grigorios Tsigkas, George Lazaros, George Kassimis, Nikolaos Fragakis, Vassilios Vassilikos, Ioannis Zarifis, Dimitrios N. Tziakas, Konstantinos Tsioufis, Periklis Davlouros, George Giannakoulas
Summary: This study aims to develop an AI-based model to transform unstructured EHR data into an organized, interpretable dataset and form a national dataset of cardiac patients. Natural language processing techniques will facilitate data mining from the unstructured EHRs. The accuracy of the automated model will be compared with manual data extraction by study investigators.
Review
Respiratory System
Kaushiga Krishnathasan, Andrew Constantine, Isma Rafiq, Ana Barrradas Pires, Hannah Douglas, Laura C. Price, Konstantinos Dimopoulos
Summary: Pregnancy is generally contraindicated in PAH due to high maternal mortality. Specialist care and counseling are essential for women with PAH wishing to become pregnant, in order to minimize risk and improve outcomes.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Dimitra Vlachopoulou, Charalampos Balomenakis, Anastasios Kartas, Athanasios Samaras, Andreas S. Papazoglou, Dimitrios V. Moysidis, Konstantinos Barmpagiannos, Melina Kyriakou, Anastasios Papanastasiou, Amalia Baroutidou, Ioannis Vouloagkas, Apostolos Tzikas, George Giannakoulas
Summary: This study found that patients with comorbid atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD) had an increased risk of all-cause and cardiovascular mortality. However, the use of cardioselective versus non-cardioselective beta-blockers did not affect clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Piera Ricci, Konstantinos Dimopoulos, Melissa Bouchard, Cheryl Chong Zhiya, Virginia Castro Meira, Danielle Pool, Michelle Lambell, Isma Rafiq, Aleksander Kempny, Ee Ling Heng, Michael A. Gatzoulis, Loredana Haidu, Andrew Constantine
Summary: Less than one-third of adolescents with congenital heart disease (CHD) successfully transition to adult care and miss out on education about their condition. We assessed the efficacy of our transition clinic and identified factors associated with successful transition.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Athanasios Samaras, Konstantinos Papadopoulos, George Giannakoulas, Apostolos Tzikas
Summary: This case report presents the successful transcatheter closure of perimembranous ventricular septal defect in an adult patient using a single transradial artery access. The approach is simpler and has potential advantages compared to traditional methods.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Elena Surkova, Andrew Constantine, Zhuoyuan Xu, Teresa Segura de la Cal, Daniela Bispo, Cathy West, Roxy Senior, Konstantinos Dimopoulos, Wei Li
Summary: This study aimed to evaluate the additional prognostic significance of echocardiographic parameters in patients with a systemic right ventricle (SRV). The results showed that echocardiographic parameters can predict mortality and transplantation rates in these patients, and the assessment of subpulmonary left ventricular (LV) size and function is closely related to prognosis. Accurate echocardiographic evaluation of SRV and subpulmonary LV is therefore crucial for risk stratification and patient management.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Barradas-Pires, Pablo Meras, Andrew Constantine, Giulia Costola, Teresa Segura de la Cal, Isma Rafiq, Aleksander Kempny, Wei Li, Sonya V. Babu-Narayan, J. Andreas Hoschtitzky, Michael A. Gatzoulis, Antonio Martinez Rubio, Konstantinos Dimopoulos
Summary: This study investigates the indications and outcomes of aortic valve replacement (AVR) in young adults with severe aortic regurgitation, as well as the relationship between presurgical echocardiographic parameters and postoperative left ventricular size and function. The results show that a higher presurgical left ventricular end-systolic diameter is associated with a lack of left ventricular normalization after AVR. Pre- and postoperative left ventricular dimensions and postoperative left ventricular ejection fraction predict clinical events during follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sian Chivers, Aoife Cleary, Rachel Knowles, Sonya Babu-Narayan, John M. Simpson, Heba Nashat, Konstantinos Dimopoulos, Michael A. Gatzoulis, Dirk Wilson, Milos Prica, James Anthony, Paul F. Clift, Victoria Jowett, Petra Jenkins, Bernadette Khodaghalian, Caroline B. Jones, Antonia Hardiman, Catherine Head, Owen Miller, Natali A. Y. Chung, Umar Mahmood, Frances A. Bu'Lock, Tristan K. W. Ramcharan, Ashish Chikermane, Jennifer Shortland, Andrew Tometzki, David S. Crossland, Zdenka Reinhardt, Clive Lewis, Leila Rittey, Dominic Hares, Olga Panagiotopoulou, Benjamin Smith, Muhammad L. Najih, Tara Bharucha, Piers E. F. Daubeney
Summary: This study examines the impact of COVID-19 on patients with congenital heart disease (CHD) and identifies risk factors for adverse outcomes. The study finds that children with CHD have a lower risk of death and hospitalization due to COVID-19, but younger children have higher hospital admission rates. In adults, the likelihood of death increases with age and pulmonary arterial hypertension, while the likelihood of hospitalization increases with age, comorbidities, and genetic disease.
Correction
Cardiac & Cardiovascular Systems
[Anonymous]
EUROPEAN HEART JOURNAL
(2023)
Article
Biology
Georgios E. Papadopoulos, Alexandra Arvanitaki, Eleftherios Markidis, Sophia Anastasia Mouratoglou, Ioannis T. Farmakis, Panagiotis Gourgiotis, Thomas Chrysochoidis Trantas, Christos Feloukidis, Antonios Kouparanis, Matthaios Didagelos, Vasilis Grosomanidis, Antonios Ziakas, George Giannakoulas
Summary: This retrospective cohort study examined the diagnostic hemodynamic profile and survival of pulmonary hypertension (PH) patients, finding improvements in both aspects over time. The findings underscore the importance of timely diagnosis and successful treatment strategies in PH.
Review
Medicine, General & Internal
Despoina Ntiloudi, Spyridon Rammos, Maria Karakosta, Alkistis Kalesi, Nearchos Kasinos, George Giannakoulas
Summary: With the increase in age of CHD patients, the prevalence of atrial arrhythmias is expanding. Managing comorbidities and using pharmacotherapy and ablation therapy are important in arrhythmia management. However, recommendations for the use of implantable cardioverter defibrillators for primary prevention in CHD patients, except for tetralogy of Fallot patients, are still not well established.
JOURNAL OF CLINICAL MEDICINE
(2023)