Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 22, Issue 5, Pages 741-746Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.04.002
Keywords
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Funding
- National Science Foundation [DMR-0848340]
- Maryland Stem Cell Research Commission [2009-MSCRFE-0084]
- Military Medical Research and Development Program [W81XWH-11-2-0047]
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Limitations in current nerve regeneration techniques have stimulated the development of various approaches to mimic the extrinsic cues available in the natural nerve regeneration environment. Biomaterials approaches modulate the microenvironment of a regenerating nerve through tailored presentation of signaling molecules, creating physical and biochemical guidance cues to direct axonal regrowth across nerve lesion sites. Cell-based approaches center on increasing the neurotrophic support, adhesion guidance and myelination capacity of Schwann cells and other alternative cell types to enhance nerve regrowth and functional recovery. Recent advances in presenting directional guidance cues in nerve guidance conduits and improving the regenerative outcomes of cell delivery provide inspirations to engineering the next generation of nerve repair solutions.
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