Journal
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 27, Issue 1, Pages E22-E27Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.neuropsych.13060141
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Funding
- Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Awards in Alzheimer's Disease
- Massachusetts Alzheimer's Disease Research Center [P50 AG005134]
- Harvard Aging Brain Study [P01 AGO36694, R01 AG037497]
- Harvard Medical School Scholars in Medicine Office
- [R01 AG027435]
- [K23 AG033634]
- [K24 AG035007]
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Apathy is a common neuropsychiatric symptom in Alzheimer's disease dementia and amnestic mild cognitive impairment and is associated with cortical atrophy in Alzheimer's disease dementia. This study investigated possible correlations between apathy and cortical atrophy in 47 individuals with mild cognitive impairment and 19 clinically normal elderly. Backward elimination multivariate linear regression was used to evaluate the cross-sectional relationship between scores on the Apathy Evaluation Scale and thickness of several cortical regions and covariates. Lower inferior temporal cortical thickness was predictive of greater apathy. Greater anterior cingulate cortical thickness was also predictive of greater apathy, suggesting an underlying reactive process.
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