Article
Medicine, Research & Experimental
Nicole A. LaHood, Jungki Min, Tarun Keswani, Crystal M. Richardson, Kwasi Amoako, Jingjia Zhou, Orlee Marini-Rapoport, Herve Bernard, Stephane Hazebrouck, Wayne G. Shreffler, J. Christopher Love, Anna Pomes, Lars C. Pedersen, Geoffrey A. Mueller, Sarita U. Patil
Summary: Oral immunotherapy (OIT) treats food allergies by gradually increasing oral allergen exposure. However, it only induces sustained clinical tolerance in a subset of patients. By studying the allergen-specific antibodies from OIT patients with sustained and transient responses, researchers identified specific tolerance-associated epitopes recognized by neutralizing antibodies. These antibodies effectively neutralize the allergen and prevent allergic reactions. This study provides insights into antibody-mediated protection in food allergies and opens possibilities for treatments using neutralizing antibodies and hypoallergens.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Food Science & Technology
Lisa Tuppo, Ivana Giangrieco, Maurizio Tamburrini, Claudia Alessandri, Adriano Mari, Maria Antonietta Ciardiello
Summary: Several factors can impact the allergen content and profile of a specific food, with processing procedures playing a role in decreasing or increasing allergenicity. Different methods can be used to identify allergenic proteins depending on the specific purposes. This review focuses on the advantages of the multiplex allergen microarray-based immunoassay, particularly the exploitation of an IgE-binding inhibition assay on multiplex allergen biochips. This innovative method allows the identification of many allergenic proteins recognized by IgE from allergic patients in a single test.
Article
Immunology
Lin Yang, Yaqi Yang, Qingxiu Xu, Wei Zhang, Qing Jiang, Wenjing Li, Yin Wang, Dongxia Ma, Xiaomin Lin, Baoqing Sun, Rongfei Zhu
Summary: Allergen immunotherapy can induce the production of sIgG4 to house dust mite components, but the increased sIgG4 levels do not correlate with the corresponding sIgE levels or AIT response, thus sIgG4 is not a useful biomarker for evaluating the efficacy of AIT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Christine Y. Y. Wai, Nicki Y. H. Leung, Agnes S. Y. Leung, Sai Ming Ngai, Punchama Pacharn, Yat Sun Yau, Jaime Sou Da Rosa Duque, Mike Y. W. Kwan, Orathai Jirapongsananuruk, Wai Hung Chan, Gilbert T. Chua, Qun Ui Lee, Surapon Piboonpocanun, Po Ki Ho, Joshua S. C. Wong, Shanshan Li, Kary J. Y. Xu, Gary W. K. Wong, Ka Hou Chu, Patrick S. C. Leung, Pakit Vichyanond, Ting Fan Leung
Summary: The clinical management of shrimp allergy is limited by the lack of accurate tests. In this study, the allergen repertoire of shrimp was comprehensively investigated, and the sensitization pattern and diagnostic value of these allergens in allergic subjects from different populations were compared using molecular diagnosis.
Article
Allergy
Maria Mikus, Arash Zandian, Ronald Sjoberg, Carl Hamsten, Bjorn Forsstrom, Morgan Andersson, Lennart Greiff, Mathias Uhlen, Mattias Levin, Peter Nilsson, Marianne van Hage, Mats Ohlin
Summary: The study utilized an allergome-wide microarray to examine IgE, IgG4, and IgG recognition of 731 allergens in subjects undergoing allergen-specific immunotherapy. Results showed significant induction of linear peptide-specific humoral immunity in individuals undergoing a 3-year-long immunotherapy, with differences in epitope profiles between subjects. The findings highlight the complexity and subject-specific nature of allergen epitopes recognized following allergen-specific immunotherapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Sarah A. Lyons, Paco M. J. Welsing, Mariam Hakobyan, Hannah M. Kansen, Edward F. Knol, Henny G. Otten, Ronald van Ree, Andre C. Knulst, Thuy-My Le
Summary: The study found that IgE testing for hazelnut extract and components is not accurate in predicting hazelnut allergy in adults. Therefore, challenge testing is still necessary to accurately discriminate between presence and absence of hazelnut allergy in adults from a birch-endemic country.
Review
Immunology
Huey-Jy Huang, Raffaela Campana, Oluwatoyin Akinfenwa, Mirela Curin, Eszter Sarzsinszky, Antonina Karsonova, Ksenja Riabova, Alexander Karaulov, Katarzyna Niespodziana, Olga Elisyutina, Elena Fedenko, Alla Litovkina, Evgenii Smolnikov, Musa Khaitov, Susanne Vrtala, Thomas Schlederer, Rudolf Valenta
Summary: More than 30% of the global population suffers from allergies, with allergic individuals producing IgE antibodies against environmental allergens. The development of molecular cloning and microarray technology has led to more precise and effective diagnosis of allergies, with silicon-based allergen microarrays offering increased sensitivity for detection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Craig I. McKenzie, Nirupama Varese, Pei M. Aui, Bruce D. Wines, Philip Mark Hogarth, Francis Thien, Mark Hew, Jennifer M. Rolland, Robyn E. O'Hehir, Menno C. van Zelm
Summary: The newly developed CytoBas flow cytometric assay utilizes fluorescent protein tetramers to directly stain IgE on blood basophils, allowing for rapid and reliable detection of clinically relevant allergic sensitization. The method has a high positive predictive value for disease and can be multiplexed for component-resolved and differential diagnostic testing for allergy.
Article
Biochemistry & Molecular Biology
Elena Ferrari, Daniela Breda, Alberto Spisni, Samuele E. Burastero
Summary: Exposure to the Mus m 1 aeroallergen is a significant risk factor for laboratory animal allergy. A recombinant component Mus m 1.0102 was developed for diagnostic testing, performing with adequate precision and reasonable accuracy compared to the native allergen. Further functional characterization of Mus m 1.0102 may lead to standardization and allergen-specific immunotherapy for mouse allergy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Hubert Gheerbrant, Alicia Guillien, Raphael Vernet, Christian Lupinek, Christophe Pison, Isabelle Pin, Florence Demenais, Rachel Nadif, Jean Bousquet, Winfried F. Pickl, Rudolf Valenta, Emmanuelle Bouzigon, Valerie Siroux
Summary: This study focused on the association between HLA class-II alleles and specific IgE sensitization to respiratory allergen molecules, finding that these alleles play an important role in predisposing carriers to sensitization to major pollen allergens but not to pet allergens.
Article
Agriculture, Multidisciplinary
Wenhan Kang, Jiukai Zhang, Hong Li, Ning Yu, Rui Tang, Xiulan Sun, Lei He, Jinlyu Sun, Ying Chen
Summary: In this study, a new epitope was identified and two identified epitopes were investigated from Pru p 3 overlapping peptide library using an immune slot-blot microarray assay. The stability of these epitopes was verified by experiments and the key amino acids were obtained through epitope amino acid mutation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Virology
Katarzyna Niespodziana, Katarina Stenberg-Hammar, Nikolaos G. Papadopoulos, Margarete Focke-Tejkl, Peter Errhalt, Jon R. Konradsen, Cilla Soderhall, Marianne van Hage, Gunilla Hedlin, Rudolf Valenta
Summary: Allergen exposure and rhinovirus (RV) infections are common triggers of acute wheezing exacerbations in early childhood. Increases in VP1-specific IgG and in allergen-specific IgE may serve as biomarkers for RV infections or allergen exposure. Our results suggest that, in the majority of preschool children, RV infections trigger wheezing attacks, but, in addition, allergen exposure seems to play a role as a trigger factor.
Review
Chemistry, Analytical
Tarek Kassem, Tanoy Sarkar, Trieu Nguyen, Dipongkor Saha, Fakhrul Ahsan
Summary: 3D printing technology can be used for personalized dosing pharmaceuticals as well as creating 3D models for drug screening, sensing, testing, and organ-on-chip applications. Efforts are being made to improve the limitations of this technology, such as restricted excipient choices, time constraints, industrial production limitations, and overall costs. This review provides an overview of the 3D printing process, types of materials used, and the pros and cons of different techniques in creating solid dosage forms and producing 3D models for sensing, testing, and screening substances.
Article
Pediatrics
Chenxi Liao, Xiangqing Hou, Liting Wu, Wenting Luo, Hong Zhang, Xin Sun, Yongmei Yu, Xiaohua Douglas Zhang, Baoqing Sun
Summary: This study investigated the patterns of molecular sensitization to major grass pollen allergens and cross-reactive carbohydrate determinants (CCD) in children who were sensitized to mugwort in western China. The study found that Art v 4 was the typical cross-reaction component of mugwort, and there was a wide cross-reaction among other grass pollen allergens caused by CCD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Oriol Manuel, Mirjam Laager, Cedric Hirzel, Dionysios Neofytos, Laura N. Walti, Gideon Hoenger, Isabelle Binet, Aurelia Schnyder, Susanne Stampf, Michael Koller, Matteo Mombelli, Min Jeong Kim, Matthias Hoffmann, Katrin Koenig, Christoph Hess, Anne-Valerie Burgener, Pietro E. Cippa, Kerstin Huebel, Thomas F. Mueller, Daniel Sidler, Suzan Dahdal, Franziska Suter-Riniker, Jean Villard, Andrea Zbinden, Giuseppe Pantaleo, Nasser Semmo, Karine Hadaya, Natalia Enriquez, Pascal R. Meylan, Marc Froissart, Dela Golshayan, Thomas Fehr, Uyen Huynh-Do, Manuel Pascual, Christian van Delden, Hans H. Hirsch, Peter Jueni, Nicolas J. Mueller, Swiss Transplant Cohort Study STCS
Summary: This study examined the use of immune monitoring to individualize the duration of antiviral prophylaxis after transplantation. The results showed that immune monitoring led to a significant reduction in prophylaxis duration, but did not establish noninferiority in terms of the primary outcome of CMV infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Business
Fabio Bertoni, Stefano Bonini, Vincenzo Capizzi, Massimo G. Colombo, Sophie Manigart
Summary: Digitization in finance creates new channels while also raising concerns such as fraud, cybersecurity, and bubbles, with traditional investors adapting to changes brought by artificial intelligence and machine learning. This special issue delves into the economic, cultural, and regulatory factors of fintech development, as well as the new forms of information production and processing in digital entrepreneurial finance.
ENTREPRENEURSHIP THEORY AND PRACTICE
(2022)
Editorial Material
Allergy
Sergio Bonini, Oliver Pfaar
Review
Allergy
Silvana Fiorito, Marzia Soligo, Yadong Gao, Ismail Ogulur, Cezmi A. Akdis, Sergio Bonini
Summary: Research suggests that the high incidence and increased mortality of COVID-19 in Northern Italy may be attributed to severe air pollution and disrupted epithelial barriers. The region's high levels of fine particulate matter contribute to increased susceptibility to the virus, while barrier dysfunction caused by air pollution can lead to chronic inflammation and impaired immune response. These factors also contribute to the higher prevalence of comorbidities and therefore increased mortality from COVID-19.
Article
Allergy
Marek Jutel, Maria J. Torres, Oscar Palomares, Cezmi A. Akdis, Thomas Eiwegger, Eva Untersmayr, Domingo Barber, Magdalena Zemelka-Wiacek, Anna Kosowska, Elizabeth Palmer, Stefan Vieths, Vera Mahler, Walter G. Canonica, Kari Nadeau, Mohamed H. Shamji, Ioana Agache
Summary: Immune modulation is a crucial treatment approach for allergic diseases, asthma, and autoimmunity. The COVID-19 vaccine has the potential to combat the global pandemic, but its administration needs to be considered in conjunction with allergen immunotherapy and biologicals.
Article
Cardiac & Cardiovascular Systems
Kenneth R. Chapman, Giorgio Walter Canonica, Kim L. Lavoie, Natalia Nenasheva, Gabriel Garcia, Sinthia Bosnic-Anticevich, Arnaud Bourdin, Maria Carmen del Cano, P. G. Abhijith, Bhumika Aggarwal
Summary: According to the 2021 GINA report, physicians tend to prefer a preventive regular dosing approach for treating patients with moderate to severe asthma, rather than using short-acting beta 2-agonists. However, many patients on the maintenance and reliever therapy (MART) request additional rescue inhalers, suggesting a misapplication of MART therapy.
RESPIRATORY MEDICINE
(2022)
Editorial Material
Otorhinolaryngology
Francesco Giombi, Alejandra Carron-Herrero, Francesca Pirola, Giovanni Paoletti, Emanuele Nappi, Elena Russo, Armando De Virgilio, Giuseppe Mercante, Giorgio Walter Canonica, Giuseppe Spriano, Enrico Heffler, Luca Malvezzi
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Review
Respiratory System
Giovanni Paoletti, Jack Pepys, Marta Casini, Danilo Di Bona, Enrico Heffler, Celine Y. Y. Goh, David B. Price, Giorgio Walter Canonica
Summary: The introduction of novel biologic drugs has revolutionised the treatment of severe asthma, but evaluating their real-life effectiveness is crucial for tailoring the right treatment for patients.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Allergy
Jaime Sanchez-Lopez, Enrico Heffler, Giorgio Walter Canonica
Summary: This study aimed to evaluate the impact of the COVID-19 pandemic on the perceptions and administration of allergen immunotherapy (AIT) in Italy. The results showed that Italian physicians did not perceive an added risk of AIT therapy for patients with allergic asthma or rhinitis during the pandemic. However, there was a decrease in the initiation of AIT therapy, and sublingual AIT was preferred over subcutaneous AIT.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Health Care Sciences & Services
Gabriele Rumi, G. Walter Canonica, Juliet M. Foster, Niels H. Chavannes, Giuseppe Valenti, Rosario Contiguglia, Eleni Rapsomaniki, Janwillem W. H. Kocks, Dario De Brasi, Fulvio Braido
Summary: The study investigates the implementation of the Turbu+ program in community settings to support asthma self-management and medication adherence. The results show high medication adherence, which may be attributed to the use of electronic monitoring and feedback mechanism provided by the Turbu+ program.
JMIR MHEALTH AND UHEALTH
(2022)
Correction
Health Care Sciences & Services
Gabriele Rumi, G. Walter Canonica, Juliet M. Foster, Niels H. Chavannes, Giuseppe Valenti, Rosario Contiguglia, Eleni Rapsomaniki, Janwillem W. H. Kocks, Dario De Brasi, Fulvio Braido
JMIR MHEALTH AND UHEALTH
(2022)
Article
Allergy
Gianenrico Senna, Maria Aliani, Elena Altieri, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Cristiano Caruso, Maria D'Amato, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Jan Walter Schroeder, Alessandra Vultaggio, Sara Rizzoli, Alessandro Zullo, Silvia Boarino, Marilena Palmisano, Alessandra Rossi, Gianfranco Vitiello, Stefano Centanni
Summary: The post hoc analysis from the Italian study ANANKE aimed to define the clinical features and effectiveness of benralizumab in the BEC 300-450 cells/mm3 subset of patients. Results showed that patients in this subset had similar improvements in exacerbation rate, asthma control, lung function, and corticosteroid use after 48 weeks of benralizumab treatment compared to the total population.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Immunology
Erminia Ridolo, Alessandro Barone, Francesca Nicoletta, Giovanni Paoletti, Enrico Heffler, Luca Malvezzi, Giorgio Walter Canonica
Summary: Allergic rhinitis (AR) is a common disease with a significant impact on quality of life and high management costs. The use of multiple drugs for symptom control in AR patients often leads to poor therapeutic adherence. However, the novel intranasal corticosteroid/antihistamine combination, GSP301, has shown promising efficacy and safety in providing rapid symptom relief and good tolerability.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
M. K. Church, G. W. Canonica, P. Kuna, M. Maurer, R. Moesges, Z. Novak, N. G. Papadopoulos, P. Rodriguez del Rio
Summary: Allergic rhinoconjunctivitis and chronic urticaria have detrimental effects on cognitive functions, sleep, daily activities, and quality of life. Non-sedating second-generation H-1 antihistamines, including bilastine, are effective treatments for these conditions.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Allergy
G. Walter Canonica, Ioana Agache, Holger J. Schunemann, Nicolas Roche, David Price, Stefano del Giacco
Review
Respiratory System
Manuela Latorre, Riccardo Pistelli, Giovanna Elisiana Carpagnano, Alessandro Celi, Ilaria Puxeddu, Nicola Scichilone, Antonio Spanevello, Giorgio Walter Canonica, Pierluigi Paggiaro
Summary: This article traces the concept of asthma control within GINA guidelines over the past 25 years. It discusses the shift in focus from controlling all clinical and functional characteristics of asthma to prioritizing the prevention of exacerbations. The importance of symptom control and the relationship between symptoms and exacerbations in moderate-severe asthma are highlighted.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)