Article
Allergy
Xian Li, Xu Xu, Jingyun Li, Yanran Huang, Chengshuo Wang, Yuan Zhang, Luo Zhang
Summary: The study found that the total societal cost for adult AR and NAR patients in Beijing is around euro 440.9 million and euro 671.9 million per year respectively. Factors such as patient's level of education, disease duration, predilection time of disease, severity of symptoms and comorbidity with other allergic diseases all affect the economic burden on patients with rhinitis.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Medicine, Research & Experimental
Alan D. Workman, Lillian Dattilo, Vinay K. Rathi, Neil Bhattacharyya
Summary: Over the past decade, the number of patients receiving medical care for allergic rhinitis has significantly decreased, as well as the per-person healthcare expenditure associated with an AR diagnosis. The transition of nasal corticosteroids to over-the-counter may have been a key driver behind these changes.
Article
Allergy
Jean Bousquet, Detlef Schroeder-Bernhardi, Claus Bachert, G. Walter Canonica, Victoria Cardona, Elisio M. Costa, Wienczyslawa Czarlewski, Philippe Devillier, Joao A. Fonseca, Ludger Klimek, Piotr Kuna, Olga Lourenco, Joaquim Mullol, Oliver Pfaar, Nhan Pham-Thi, Boleslaw Samolinski, Julia Saueressig, Glenis K. Scadding, Ann-Kathrin Stroh, Sophie Scheire, Eric Van Ganse, Torsten Zuberbier
Summary: The study on the rhinitis market in EU countries revealed significant differences in medication usage for allergic rhinitis, with France leading in Standard Units and costs, while Poland had lower costs compared to the other three countries.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Allergy
Victor Gonzalez-Uribe, Helena Vidaurri-de la Cruz, Andres Gomez-Nunez, Jordi A. Leyva-Calderon, Zaira S. Mojica-Gonzalez
Summary: This review summarizes the burden and comorbidities of atopic dermatitis, including an increased risk of asthma and other allergic manifestations, as well as skin diseases. Lifestyle factors and smoking may modify the frequency of these comorbidities. In addition, atopic dermatitis is associated with psychiatric consequences, particularly in severe cases.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Dorota Myszkowska, Monika Bazgier, Sara Bronska, Karol Nowak, Joanna Ozga, Aleksandra Wozniak, Andrzej Stanisz, Joanna Szaleniec
Summary: Nasal scraping cytology is a non-invasive tool used in the diagnostics of allergic and non-allergic rhinitis. The study aims to analyze the correlation between cytological picture of the nasal mucosa and the diagnosis of the disease, considering the content of eosinophils. The findings suggest that there is a significant relationship between the epithelial cell to inflammatory cell ratio and the four disease groups. It was also observed that the level of eosinophils increases with more intensive inflammation. Allergic rhinitis shows a different cytological picture compared to other diseases, with a lower amount of eosinophils detected, except for allergic rhinitis caused by pollen allergens.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Elena Cantone, Aikaterini Detoraki, Eugenio De Corso
Summary: This review discusses the features of local allergic rhinitis (LAR) as an independent endotype. Allergic rhinitis (AR) and nonallergic rhinitis (NAR) are two subtypes of chronic rhinitis, while LAR is a subtype of AR characterized by a localized nasal allergic response with negative skin prick testing to allergens in the absence of serum-specific IgE.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Nadia T. Saif, Gary I. Kleiner, Lourdes Q. Forster, Eugene R. Hershorin, Andrew A. Colin, Mehdi Mirsaeidi, Naresh Kumar
Summary: This study investigated the role of allergies and associated comorbidities in pediatric asthma, finding that multiple allergies increase the risk of asthma, while the home environment plays a crucial role in sensitizing individuals to allergens. Early screening and treatment are essential for managing pediatric asthma effectively.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, Research & Experimental
Jin Youp Kim, Yujin Park, Su Hwan Kim, Seong Pyo Kim, Seok-Won Park, Hyung-Jin Yoon
Summary: This study found that the concentrations of PM10, NO2, and CO in ambient air are significantly associated with increased medical costs of allergic rhinitis (AR), with each standard deviation increase in concentration resulting in a percentage increase in medical costs.
Article
Pediatrics
Gheorghita Jugulete, Monica Luminos, Carmen Pavelescu, Madalina Maria Merisescu
Summary: COVID-19 has a milder impact on children compared to adults, but the emergence of new SARS-CoV-2 variants has affected treatment options for both adults and children, particularly those with allergies. This study evaluates the efficacy and tolerability of Remdesivir (RDV) in treating pediatric patients with COVID-19-associated allergies and investigates its impact on hospitalization duration. The findings suggest that RDV reduces the duration and severity of COVID-19 in children with allergies, leading to shorter hospital stays.
Article
Multidisciplinary Sciences
Chao-Yi Wu, Hsin-Yi Huang, Wen-Chi Pan, Sui-Ling Liao, Man-Chin Hua, Ming-Han Tsai, Shen-Hao Lai, Kuo-Wei Yeh, Li-Chen Chen, Jing-Long Huang, Tsung-Chieh Yao
Summary: This study revealed that nearly half of allergic diseases in Asian children in Taiwan are attributable to atopy, with a higher risk among adolescents. Sensitization to mites had the highest population attributable risks for all three allergic diseases, followed by sensitization to foods.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Munsoo Han, Dabin Lee, Sang Hag Lee, Tae Hoon Kim
Summary: Oxidative stress plays a crucial role in redox metabolism in various physiological and pathological conditions, and antioxidants are important in treating associated diseases. Allergic rhinitis significantly impacts daily function and quality of life, with a high socioeconomic burden and prevalence, with recent studies focusing on the role of oxidative stress and antioxidants in this condition.
Review
Allergy
Yuan Zhang, Feng Lan, Luo Zhang
Summary: Allergic rhinitis is a growing global public health issue, and future research should focus on environmental exposures, climate changes, and their impact on health. A combination of precise diagnosis and traditional methods may enhance the treatment of allergic rhinitis.
Article
Immunology
Weitian Zhang, Xiwen Sun, Guangyi Ba, Ru Tang, Hai Lin
Summary: The study demonstrated that RGFP966, a selective inhibitor of HDAC3, attenuated allergic and inflammatory responses in murine AR by reducing levels and activities of HDAC3. This led to a decrease in the recruitment of eosinophils and mast cells, proliferation of goblet cells, and levels of inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Joseph P. Tkacz, Karen Rance, Douglas Waddell, Mark Aagren, Eva Hammerby
Summary: This study assessed total and allergic rhinitis (AR)-related healthcare costs among AR patients in the United States, with a focus on patients persisting with AIT. Patients initiating AIT had higher baseline comorbidities compared to non-AIT patients, but those reaching the maintenance phase of AIT incurred lower total costs. Despite presenting more comorbidities, AIT patients showed cost decreases following treatment initiation, highlighting the potential benefits of AIT in managing allergic rhinitis.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)