Article
Biochemistry & Molecular Biology
Hyunjae Yu, Dong-Kyu Kim
Summary: Machine-learning algorithms were used to investigate the factors associated with the recurrence of CRSwNP following sinus surgery. Neutrophil inflammation was found to be an important factor affecting surgical outcomes, with tissue neutrophilia being the most important variable in determining recurrence. The study suggests that increased neutrophilic inflammation is associated with poor surgical outcomes in patients with difficult-to-treat CRSwNP.
Article
Allergy
Shigeharu Fujieda, Shoji Matsune, Sachio Takeno, Nobuo Ohta, Mikiya Asako, Claus Bachert, Tomoyuki Inoue, Yoshinori Takahashi, Hiroyuki Fujita, Yamo Deniz, Paul Rowe, Benjamin Ortiz, Yongtao Li, Leda P. Mannent
Summary: Dupilumab consistently improved symptoms of severe CRSwNP in all ECRS subgroups, regardless of ECRS status. Blood eosinophil level may not be a suitable biomarker for dupilumab efficacy in CRSwNP.
Review
Medicine, General & Internal
Jose Palacios-Garcia, Cristina Porras-Gonzalez, Ramon Moreno-Luna, Juan Maza-Solano, Juan Polo-Padillo, Jose Luis Munoz-Bravo, Serafin Sanchez-Gomez
Summary: Chronic rhinosinusitis with nasal polyps is an inflammatory disease characterized by the presence of nasal polyps. Our systematic review evaluated the inflammatory role of fibroblasts in nasal polyps and found that they secrete various cytokines involved in multiple inflammatory pathways. These findings suggest that fibroblasts may be a potential therapeutic target in the treatment of chronic rhinosinusitis with nasal polyps.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Jin Youp Kim, Suha Lim, Hee-Suk Lim, Yi-Sook Kim, Kyoung Mi Eun, Roza Khalmuratova, Yuju Seo, Joon Kon Kim, Young Seok Kim, Min-Kyung Kim, Siyeon Jin, Seung Cheol Han, Suyeon Pyo, Seung-No Hong, Jong-Wan Park, Hyun-Woo Shin, Dae Woo Kim
Summary: The role of BMPs in osteitis in patients with CRSwNPs and their associations with inflammatory markers are not fully investigated. Among the 6 BMPs studied, BMP-2 may be a novel biomarker for refractory CRSwNP with potential implications for mucosa and bone remodeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Meiping Zhang, Yishan Xiong, Junhao Tu, Binxiang Tang, Zhiqiang Zhang, Jieqing Yu, Li Shen, Qing Luo, Jing Ye
Summary: This study found that hypoxia can disrupt the nasal epithelial barrier in chronic rhinosinusitis with nasal polyps (CRSwNP), and the mechanism may be through the downregulation of PTPN2 and tight junction (TJ) components. HIF-1 alpha and PTPN2 may be potential targets for the treatment of CRSwNP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Meiping Zhang, Binxiang Tang, Ligui Huang, Yishan Xiong, Junhao Tu, Yizhen Jia, Fan Jiang, Li Shen, Qing Luo, Jing Ye
Summary: Hypoxia-induced upregulation of hypoxia-inducible factor-1a (HIF-1a) promotes the expression of epithelial-derived cytokines (EDCs), including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP), in nasal polyps, leading to the development of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). Inhibition of HIF-1a with PX-478 effectively suppresses EDC expression and type 2 immune responses in vitro and in a mouse model, suggesting that targeting HIF-1a may be a potential therapeutic strategy for ECRSwNP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Brian J. Lipworth, Rory Chan
Summary: Patients with severe chronic rhinosinusitis with nasal polyps who do not respond well to current medical and surgical therapy may benefit from targeting type 2 inflammatory cytokines (IL 4/5/13). Biologics such as mepolizumab, omalizumab, and dupilumab have shown promising results in improving nasal polyp scores and health status in clinical trials. Further real-life studies are needed to assess the response in patients at increased risk for disease recurrence.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Otorhinolaryngology
Yusuf Cagdas Kumbul, Hasan Yasan, Erdogan Okur, Mustafa Tuz, Mehmet Emre Sivrice, Vural Akin, Fevziye Burcu Sirin, Eltaf Dogan Kiran
Summary: The aim of this study was to investigate the possible role of raftlin (RFTN) in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that the tissue levels of RFTN were significantly lower in the CRSwNP group compared to the control group, suggesting a potential involvement of RFTN deficiency in the development of CRSwNP.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Yujie Cao, Xianting Hu, Chun Zhou, Keqing Zhao, Yaoming Zheng, Wenxiu Jiang, Dehui Wang, Huabin Li
Summary: The study found that IL-1 alpha is significantly increased in NP tissues of CRSwNP patients in China and is mainly located in epithelial cells and neutrophils. IL-1 alpha in polyp tissues is associated with the production of IL-8, IL-1 beta, IL-6, IL-4, and IL-13, as well as tissue neutrophil infiltration. In vitro experiments showed that several stimuli, including poly (I:C), lipopolysaccharides, Flagellin, R848, and cytokines (IL-4, IL-5, and IL-13), increase the expression of IL-1 alpha in cultured NECs, and recombinant IL-1 alpha promotes the production of IL-8 and CXCL1.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Allergy
Bruce S. Bochner, Whitney W. Stevens
Summary: Chronic rhinosinusitis (CRS) is a complex medical condition characterized by chronic innate and adaptive mucosal inflammation, often treated with corticosteroids and sinus surgery, but newer biologics have been evaluated as alternatives. Studies suggest that a prominent feature in CRS is type 2 inflammation, including tissue eosinophilia.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
Article
Otorhinolaryngology
G. Yilmaz, H. Eyigor, O. E. Gur, T. Kalkan, N. Gur, O. T. Selcuk, Ozturk Yilmaz, E. A. Cetinkaya
Summary: This study aimed to investigate the relationship between TAS2R38 genotype and surgical outcomes, as well as the active microorganism, in chronic rhinosinusitis patients. The results showed no statistically significant association between TAS2R38 genotype and CRS subtype, sinonasal bacterial infection risk increase, and surgical success rate. Further long-term and large-scale studies are needed to explore the effects of these genetic variants.
Article
Otorhinolaryngology
Guan-Jiang Huang, Hong-Bing Liu
Summary: This study investigated the relationship between chronic rhinosinusitis with nasal polyps (CRSwNP) and ferroptosis, and identified important ferroptosis-related genes in CRSwNP. Through bioinformatics analysis and experimental verification, CDO1 and GPX2 were found to be the key genes associated with ferroptosis in CRSwNP.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Yeon-Hee Joo, Hyun-Jin Cho, Yung Jin Jeon, Jin Hyun Kim, Myeong Hee Jung, Sea-Yuong Jeon, Young Sun Suh, Jung Je Park, Sang-Wook Kim
Summary: The study demonstrated that topical tofacitinib can reduce polyp formation and eosinophilic infiltration in a mouse model of chronic rhinosinusitis with nasal polyps, with efficacy comparable to systemic triamcinolone acetonide. It works by inhibiting phosphorylation of STATs, decreasing GATA-3 gene expression levels, and reducing IL-4 and IL-5 production, while increasing interferon-gamma production.
Article
Cell Biology
Yanyi Tu, Jing Liu, Tao Li, Xiangmin Zhou, Kai Sen Tan, Hsiao Hui Ong, Kaiyue Sun, Yi Ouyang, Xu Liang, Yew Kwang Ong, Mark Thong, Li Shi, De-Yun Wang
Summary: The study found differences in nasal mucus composition between healthy individuals and chronic rhinosinusitis patients, which may contribute to the pathology of chronic nasal diseases, mainly reflected in glandular hyperplasia and goblet cell hyperplasia.
Article
Otorhinolaryngology
Thiago Freire Pinto Bezerra, Rogerio Pezato, Pamella Marletti de Barros, Larissa Leal Coutinho, Leidianny Firmino Costa, Fabio Pinna, Richard Voegels
Summary: The study found that long-term adjuvant use of low-dose clarithromycin in patients with recurrent chronic rhinosinusitis with sinonasal polyposis can improve quality of life and nasal endoscopy findings, especially in patients with normal IgE levels.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2021)