Journal
CURRENT ONCOLOGY
Volume 21, Issue 4, Pages E658-E662Publisher
MULTIMED INC
DOI: 10.3747/co.21.1956
Keywords
Osteosarcoma; epiphysis preservation; epiphysiolysis; distraction osteogenesis; limb function; quality of life
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In an 11-year-old boy with osteosarcoma in the proximal tibia (type III), 2 cycles of DIA chemotherapy (cisplatin, ifosfamide, doxorubicin) were administered preoperatively while epiphysiolysis was performed. Clinical response was determined to be complete by radiography and histopathology. Marginal excision was then performed with preservation of the proximal tibial epiphysis. Metaphyseal reconstruction was performed using distraction osteogenesis. Six cycles of dia chemotherapy were administered postoperatively. Twenty months later, the patient had developed no complications and experienced full bone healing, with no limb discrepancy. In selected adolescent patients with osteosarcoma, in whom the tumour is in full contact with the epiphysis, epiphyseal preservation by epiphysiolysis and reconstruction by distraction osteogenesis can provide an excellent outcome, resulting in a stable reconstruction that functionally restores the native limb.
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