Review
Biochemistry & Molecular Biology
Abdelrahman AlAshqar, Bethlehem Lulseged, Akailah Mason-Otey, Jinxiao Liang, Umme Aoufa Mafruha Begum, Sadia Afrin, Mostafa A. Borahay
Summary: In recent decades, our understanding of the complex pathobiology of uterine fibroid development has expanded. It is now known that uterine fibroids have different aspects of their genesis and oxidative stress plays an important role in their development. The influence of oxidative stress on fibroid development is mediated through genetic, epigenetic, and profibrotic mechanisms. This knowledge has led to clinical implications for diagnosis and treatment using biomarkers and antioxidants.
Article
Agriculture, Dairy & Animal Science
Renato M. Rossi, Faith M. Cullens, Paola Bacigalupo, Lorraine M. Sordillo, Angel Abuelo
Summary: The objective of this observational study was to compare the metabolic status of dairy cows during the last 6 wk of gestation based on colostrum volume and immunoglobulin content. The results showed that colostrum volume was lowest in winter, but no differences were observed among parity groups. Compared with low colostrum producer, high colostrum producer cows had higher concentrations of antioxidant potential and beta-hydroxybutyrate, and lower cholesterol and oxidant status index.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Critical Care Medicine
Po-An Tai, Chen-Kuei Chang, Ko-Chi Niu, Mao-Tsun Lin, Wen-Ta Chiu, Jia-Wei Lin
Summary: The study found that hyperbaric oxygen therapy was more effective in prolonging the survival time of heatstroke rats compared to normobaric air therapy. Rats treated with hyperbaric oxygen showed lower levels of hypotension, oxidative stress, and inflammation compared to the normothermic control group. Delaying the onset of hyperbaric oxygen therapy reduced its therapeutic efficiency.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Biochemistry & Molecular Biology
Maria E. E. Bernis, Margit Zweyer, Elke Maes, Yvonne Schleehuber, Hemmen Sabir
Summary: The peripheral immune system plays a critical role in neuroinflammation of the central nervous system after an insult. In this study, a neonatal model of experimental hypoxic-ischemic (HI) brain injury was used to investigate the activation of neutrophils and the formation of neutrophil extracellular traps (NETs). The results suggest the important pathological functions of early arriving neutrophils and NETosis following neonatal HI, particularly after therapeutic hypothermia (TH) treatment, which could serve as a potential therapeutic target for neonatal hypoxic-ischemic encephalopathy (HIE).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Maria Ferraro, Serena Di Vincenzo, Claudia Sangiorgi, Stefania Leto Barone, Sebastiano Gangemi, Luigi Lanata, Elisabetta Pace
Summary: This study assessed the effects of carbocysteine on patients with Chronic Obstructive Pulmonary Disease (COPD) during acute exacerbation. The results showed that carbocysteine improved symptoms, reduced levels of inflammatory markers, and helped manage mild AECOPD.
Article
Biochemistry & Molecular Biology
Hamad Mohammed AbuZahra, Peramaiyan Rajendran, Mohammad Bani Ismail
Summary: Zerumbone has shown potential in alleviating ZEA-induced liver damage, reducing inflammation, and inhibiting cell apoptosis through various pathways, providing a basis for its application in treating liver injuries caused by contaminants, such as Zearalenone.
Review
Biochemistry & Molecular Biology
Isabel Medina-Vera, Lizzette Gomez-de-Regil, Ana Ligia Gutierrez-Solis, Roberto Lugo, Martha Guevara-Cruz, Jose Pedraza-Chaverri, Azalia Avila-Nava
Summary: This study compiled scientific literature on dietary strategies using foods with antioxidant effect to improve antioxidant status in individuals with dyslipidemias, finding that various foods show significant differences in blood lipids, antioxidant activity, antioxidant enzymes, and oxidative and inflammatory markers.
Article
Biochemistry & Molecular Biology
E. D. Kryl'skii, E. E. Chupandina, T. N. Popova, Kh. S. Shikhaliev, V. O. Mittova, S. S. Popov, A. N. Verevkin, A. A. Filin
Summary: The study assessed the neuroprotective potential of DHQ in a CIR rat model, showing that DHQ can reduce histopathological changes, inhibit oxidative stress and inflammation, decrease apoptosis activity, and modulate antioxidant enzyme activity and gene expression.
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Miquel Navas-Madronal, Rafael Almendra-Pegueros, Lidia Puertas-Umbert, Francesc Jimenez-Altayo, Josep Julve, Belen Perez, Marta Consegal-Perez, Modar Kassan, Jose Martinez-Gonzalez, Cristina Rodriguez, Maria Galan
Summary: This study demonstrates that inhibition of mitochondrial stress using SS31 can reduce aneurysm development and attenuate endoplasmic reticulum (ER) stress. SS31 improves mitochondrial function, decreases expression of ER stress markers, and reduces reactive oxygen species (ROS) levels. Additionally, SS31-induced inhibition of ER stress reduces the incidence and severity of AAA, similar to the effects of classic ER stress inhibitors TUDCA and PBA.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kwang-Il To, Zhen-Xing Zhu, Ya-Ni Wang, Gang-Ao Li, Yu-Meng Sun, Yang Li, Ying-Hua Jin
Summary: This study investigated the drug targets and pathways of Ginsenoside Rh4 (G-Rh4) in treating inflammation using network pharmacology and experimental approaches. The results showed that G-Rh4 may exert anti-inflammatory effects through the JAK-STAT signaling pathway, TNF signaling pathway, NF-kappa B signaling pathway, and PI3K-Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Clive N. May, Rinaldo Bellomo, Yugeesh R. Lankadeva
Summary: Vitamin C has various beneficial effects and may be helpful in treating sepsis and COVID-19. Experimental evidence shows that high-dose vitamin C can significantly improve clinical symptoms and promote organ function recovery.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
R. E. Bucktrout, N. Ma, A. Aboragah, A. S. Alharthi, Y. Liang, V Lopreiato, M. G. Lopes, E. Trevisi, I. A. Alhidary, C. Fernandez, J. J. Loor
Summary: The study showed that prepartal body condition score has effects on hepatic enzymes, metabolism, and biomarkers in dairy cows. High BCS cows had higher postpartal dry matter intake and milk yield, but lower antioxidant capacity.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Paulina Pawelec, Joanna Sypecka, Teresa Zalewska, Malgorzata Ziemka-Nalecz
Summary: Givinostat/ITF2357 did not attenuate the inflammatory response after neonatal hypoxia-ischemia, with no significant changes in chemokines and cytokines, but potentially causing a decrease in MIP-1 alpha levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Andy Tran, Wenyuan He, Jim T. C. Chen, Leigh Wellhauser, Kathyrn E. Hopperton, Richard P. Bazinet, Denise D. Belsham
Summary: Consumption of a diet high in saturated fatty acids can lead to hypothalamic neuroinflammation, dysregulation of neuronal function, and induction of orexigenic neuropeptide Y (Npy). Intracellular metabolism of palmitate and metabolites like ceramide and phospholipids play a crucial role in mediating the effects of palmitate on Npy expression.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Chien-Cheng Huang, Tzu-Hao Chen, Chung-Han Ho, Yi-Chen Chen, Chien-Chin Hsu, Hung-Jung Lin, Jhi-Joung Wang, Ching-Ping Chang, How-Ran Guo
Summary: This study found an association between carbon monoxide poisoning (COP) and congestive heart failure (CHF) through epidemiological data from Taiwan and animal research, showing that COP patients have a higher risk of developing CHF, even persisting after 2 years, and these findings were supported by the animal model.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Yu-Wen Lin, Chin-Yu Chen, Jhih-Yuan Shih, Bor-Chih Cheng, Ching-Ping Chang, Mao-Tsun Lin, Chung-Han Ho, Zhih-Cherng Chen, Sudeshna Fisch, Wei-Ting Chang
Summary: The study established a MR model in rats and found that DAPA partially restored impaired cardiac function induced by MR, reduced atrial fibrillation occurrence, and attenuated cardiac fibrosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Correction
Neurosciences
Yu-Lin Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Yu-Ling Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
Summary: This study aims to investigate the beneficial effects of exercise rehabilitation and/or astragaloside in counteracting amyloid-beta pathology. The results showed that exercise rehabilitation and/or astragaloside reversed the neurobehavioral disorders and neuropathology caused by amyloid-beta. The application of BDNF and/or astragaloside also reversed the cytotoxicity and mitochondrial distress induced by amyloid-beta in cortical neurons. The combined therapy of exercise rehabilitation (or BDNF) and astragaloside showed superior therapeutic effects compared to individual treatments. The results indicate that exercise rehabilitation (or BDNF) and astragaloside attenuate amyloid-beta pathology by reversing BDNF/TrkB signaling deficits and mitochondrial dysfunction, and their combination potentiates each other's therapeutic effects. Astragaloside can be an alternative therapy to replace exercise rehabilitation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Materials Science, Coatings & Films
W. T. Lin, Z. W. Lin, T. Y. Kuo, C. S. Chien, J. W. Huang, Y. L. Chung, C. P. Chang, M. Z. Ibrahim, H. T. Lee
Summary: The addition of CNTs improves the indentation fracture toughness of Ta2O5 coatings deposited by atmospheric plasma spraying, without degrading their surface morphology and roughness. However, higher CNT content increases the coating porosity and reduces the microhardness.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Chi-Chun Chen, Yu-Lin Wang, Ching-Ping Chang
Summary: This study developed an optimised rehabilitation training system for rats with various stroke severities and used a modified ladder-climbing method for training. The results showed that this method was effective in promoting recovery for subjects with different stroke severities.
IET CIRCUITS DEVICES & SYSTEMS
(2022)
Article
Public, Environmental & Occupational Health
Chien-Cheng Huang, Tzu-Hao Chen, Chung -Han Ho, Yi-Chen Chen, Rong-Jane Chen, Ying-Jan Wang, Chien -Chin Hsu, Hung -Jung Lin, Jhi-Joung Wang, Ching -Ping Chang, How-Ran Guo
Summary: This study investigated the effects of CO poisoning on the development of diabetes and on existing diabetes through epidemiologic analyses and animal experiments. The results showed that CO poisoning increased the risks of diabetes and hyperglycemic crisis, which may be attributable to damages in the pancreas and hypothalamus.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Chemistry, Physical
Kuan-Ting Chen, Jun-Wei Huang, Wei-Ting Lin, Tsung-Yuan Kuo, Chi-Sheng Chien, Ching-Ping Chang, Yung-Ding Lin
Summary: The micro-arc oxidation (MAO) process was used to prepare hydroxyapatite-containing flower-like structure coatings on commercially pure titanium substrates. The morphology of the coatings depended on the applied voltage, with 330 V resulting in a flower-like/plate-like structure, and 390 V and 450 V resulting in a flower-like structure and a porous morphology respectively. The applied current and duration time affected the coating formation speed and petal size of the flower-like structures. The coatings with flower-like/plate-like or flower-like structures exhibited higher roughness, increased hydrophilicity, and superior bioactivity and biocompatibility. The 390 V coating had the optimal biomedical performance due to its flower-like structure and high HA/DCPD ratio.
Article
Biology
Kuan-Hua Huang, Ching-Ping Chang, Lan-Hsiang Chien, Chien-Feng Li, Ling-Yu Tang, Yu-Yi Chan, Ting-Feng Wu
Summary: This study aimed to investigate the inhibitory molecular process of pomegranate peel on urinary bladder urothelial carcinoma using a proteomics strategy. The results revealed that pomegranate peel extract can regulate various proteins involved in cell apoptosis, cell proliferation, and signaling pathways, thus inhibiting the growth and spread of cancer cells. These findings suggest that pomegranate might serve as a potential chemopreventive resource for UBUC carcinogenesis.
Article
Medicine, Research & Experimental
Chien-Ming Chao, Lin-Yu Wang, Chien-Cheng Huang, Wei-Ting Chang, Ling-Yu Tang, Mao-Tsun Lin, Chang Ching-Ping
Summary: Using a survival male rat model of acute exertional heat stroke (EHS), this study investigated the effects of EHS on myocardium structure and function. It was found that EHS caused skeletal muscle and myocardial damage, with myocardial damage lasting for at least 14 days post-EHS. This study is significant as it provides key findings on the pathophysiology and risk factors of EHS, as well as highlighting the need for further research.
Article
Neurosciences
Tian-Hoe Tan, Shih-Wen Li, Chih-Wei Chang, Yuan-Chih Chen, Yu-Hsuan Liu, Jui-Ti Ma, Ching-Ping Chang, Pao-Chi Liao
Summary: In this study, hair was found to undergo metabolic changes in rats induced with beta-amyloid, which were associated with cognitive impairments. Furthermore, these changes observed in the hair of beta-amyloid-induced rats showed a similar trend to the metabolites found in the cerebrospinal fluid of Alzheimer's disease patients. Therefore, hair can be a valuable biospecimen for assessing endogenous metabolic disturbances and identifying biomarkers of Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chien-Liang Liu, Hung-Wen Tsai, Shu-Ling Peng, Ching-Ping Chang, Yu-Hao Chang, Huei-Sheng Huang
Summary: Urine-based cytology is commonly used for clinical diagnosis of urothelial carcinoma (UC), but its sensitivity is limited for low-grade UC detection. This study found that CDCP1 expression was significantly higher in UC patients, especially those with low-grade UC, compared to normal individuals. CDCP1 expression in urinary UC cells was also detected using immunocytochemistry. The overexpression and knockdown of CDCP1 in UC cells influenced migration ability, suggesting its potential role in the malignant progression of UC.
Article
Cell Biology
Tzong-Bor Sun, Kuo-Feng Huang, Ko-Chi Niu, Cheng-Hsien Lin, Wen-Pin Liu, Chao-Hung Yeh, Shu-Chun Kuo, Ching-Ping Chang
Summary: Hyperbaric oxygen preconditioning can reverse oxygen-glucose deprivation-induced retinal pigment epithelial cell injury by activating PPAR-a signaling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Meeting Abstract
Urology & Nephrology
Kun-Lin Hsieh, Ching-Ping Chang, Kuan-Hua Huang, Allen W. Chiu
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Medicine, General & Internal
Chien-Ming Chao, Chien-Chin Hsu, Chien-Cheng Huang, Chung-Han Wang, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin, Chung-Ching Chio
Summary: Selective brain cooling during hemorrhagic shock resuscitation showed beneficial effects in protecting peripheral vital organs. By preserving the integrity of the brain-gut axis, brain cooling significantly reduced gut disruption, systemic inflammation, and peripheral vital organ injuries induced by HS resuscitation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)