Article
Biochemistry & Molecular Biology
Noha A. Gouda, Ahmed Elkamhawy, Jungsook Cho
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons. Current treatments for PD only aim to alleviate motor symptoms, and there is a need for disease-modifying approaches. This review provides an overview of current therapies, discusses novel therapeutic targets, immunomodulatory approaches, and stem cell research in PD, summarizes preclinical studies and clinical trials, and presents potential molecular biomarkers for early PD diagnosis.
Article
Biochemistry & Molecular Biology
Alexander D. Nadeev, Kristina A. Kritskaya, Evgeniya Fedotova, Alexey Berezhnov
Summary: Parkinson's disease is a common neurodegenerative disorder with no effective treatment. Mitochondrial dysfunction plays a key role in its pathogenesis. The initiation of mitophagy through transient brain acidification has shown potential in slowing down the progression of Parkinson's disease.
Editorial Material
Multidisciplinary Sciences
Zak Doric, Ken Nakamura
Summary: By disrupting mitochondria in vulnerable neuronal cells, mice provide a new model of Parkinson's disease that challenges long-held ideas about the disease's motor symptoms.
Article
Pharmacology & Pharmacy
Sandra Barreiro, Barbara Silva, Solida Long, Madalena Pinto, Fernando Remiao, Emilia Sousa, Renata Silva
Summary: This study suggests that fiscalins have neuroprotective effects against neurodegenerative diseases and potential as new drugs for treatment and prevention.
Review
Biochemistry & Molecular Biology
Sandro Huenchuguala, Juan Segura-Aguilar
Summary: Iron plays a fundamental role in various aspects of human life, but an imbalance in iron levels can lead to certain pathologies. Maintaining iron homeostasis is crucial in preventing these pathologies. While there is evidence suggesting iron's involvement in the degenerative process of Parkinson's disease, clinical studies have not shown positive effects of iron chelators in treating the disease.
Review
Neurosciences
Simon R. W. Stott, Richard K. Wyse, Patrik Brundin
Summary: The international Linked Clinical Trials program is focused on providing disease-modifying drugs for Parkinson's disease, with seven completed and 15 ongoing clinical trials. This program, which has rapidly grown since its initial planning in 2010, aims to deliver disease modification in PD by evaluating 16 agents in clinical trials. The review provides an overview of the history, structure, process, progress, and examples of agents selected and evaluated by the program.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Yong Hui Nies, Nor Haliza Mohamad Najib, Wei Ling Lim, Mohd Amir Kamaruzzaman, Mohamad Fairuz Yahaya, Seong Lin Teoh
Summary: Parkinson's disease is a severely debilitating neurodegenerative disease that affects the motor system, with mechanisms of pathogenesis still unclear. MicroRNAs play a crucial role in the regulation of PD-associated genes, dopaminergic neuron survival, and inflammation, potentially serving as diagnostic biomarkers and therapeutic tools for PD.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Antonia Pignolo, Sergio Mastrilli, Chiara Davi, Valentina Arnao, Paolo Aridon, Felipe Augusto dos Santos Mendes, Cesare Gagliardo, Marco D'Amelio
Summary: Vitamin D plays a crucial role in bone metabolism, calcium and phosphorous homeostasis, as well as brain development and neuroprotection. Patients with Parkinson's disease often have a high frequency of vitamin D deficiency, which may be related to disease severity and progression. However, the evidence regarding the use of vitamin D supplementation to reduce symptoms and disability in patients with Parkinson's disease is limited. Further clinical studies are needed to confirm the potential benefits and risks of vitamin D supplementation in this population.
Article
Immunology
Marwa M. Khalaf, Mahmoud M. El-Sayed, Mohamed A. Kandeil, Sanaa Ahmed
Summary: Parkinson's disease (PD) drugs do not stop disease progression, so finding novel therapeutic medications to halt it is crucial. Research on antidiabetic medicines is valuable for this purpose, and in this study, the neuroprotective benefits of Dulaglutide (DUL) were investigated using the PD model Rotenone (ROT).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tapan Behl, Piyush Madaan, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Sridevi Chigurupati, Ibrahim Alrashdi, Simona Gabriela Bungau
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopamine-generating nerve cells in the substantia nigra pars compacta. The etiology and pathogenesis of PD remain unclear, but genetic and environmental factors are believed to play a role. PPAR agonists have shown neuroprotective effects by modulating the expression of genes involved in cellular survival pathways, suggesting a potential therapeutic target for PD and other neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Eskandar Taghizadeh, Seyed Mohammad Gheibihayat, Forough Taheri, Seyed Mohammadreza Afshani, Najmeh Farahani, Alihossein Saberi
Summary: Parkinson's disease is a common degenerative disorder related to central nervous system damage, characterized by the formation of Lewy bodies in dopaminergic neurons. Long non-coding ribonucleic acids (lncRNAs), which play important roles in gene expression and cell differentiation, have shown disrupted expression profiles in neurodegenerative disorders such as PD. Studies have explored the potential of lncRNAs as biomarkers for PD diagnosis, treatment, and prognosis.
NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Kaitlyn M. L. Cramb, Dayne Beccano-Kelly, Stephanie J. Cragg, Richard Wade-Martins
Summary: Cramb et al. provide a review of evidence suggesting dopamine release deficits occur prior to neurodegeneration in Parkinson's disease. They also highlight the need for further investigation in understanding the mechanisms behind these deficits.
Review
Geriatrics & Gerontology
Alessandro Arrigo, Emanuela Aragona, Andrea Saladino, Davide Arrigo, Federico Fantaguzzi, Maurizio Battaglia Parodi, Francesco Bandello
Summary: Glaucoma is considered a multifaceted chronic neurodegenerative disease affecting the central nervous system, with varying degrees of cognitive impairment and severity in degeneration. While there are currently neuroprotective agents available, the development of new molecules for future clinical trials is a major topic of investigation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Neurosciences
Zhengzhe Li, Xiaoling Wang, Xiaoxing Wang, Xiaomei Yi, Yin Kwan Wong, Jiyang Wu, Fangfang Xie, Die Hu, Qi Wang, Jigang Wang, Tianyu Zhong
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, affect millions of people worldwide. Extracellular vesicles (EVs) have been shown to play a role in the pathogenic processes of these diseases and have potential as therapeutic targets or biomarkers. This review summarizes the research progress on EVs in neurodegenerative diseases and discusses their roles and therapeutic potential.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Multidisciplinary Sciences
Tae-In Kam, Hyejin Park, Shih-Ching Chou, Jonathan G. Van Vranken, Melanie J. Mittenbuhler, Hyeonwoo Kim, A. Mu, Yu Ree Choi, Devanik Biswas, Justin Wang, Yu Shin, Alexis Loder, Senthilkumar S. Karuppagounder, Christiane D. Wrann, Valina L. Dawson, Bruce M. Spiegelman, Ted M. Dawson
Summary: This study shows that irisin can prevent neurodegeneration caused by pathological alpha-synuclein in Parkinson's disease, and it also reduces motor deficits. Irisin functions by enhancing endolysosomal degradation of pathologic alpha-synuclein.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Guan-Hui Wu, Fan-Zhen Kong, Xiao-Feng Dong, De-Feng Wu, Qian-Zhu Guo, Ai-Rong Shen, Qing-Zhang Cheng, Wei-Feng Luo
METABOLIC BRAIN DISEASE
(2017)
Article
Endocrinology & Metabolism
Guan-Hui Wu, Fan-Zhen Kong, Qing-Zhang Cheng, Wei-Feng Luo, Xiang-Dong Du
NEUROENDOCRINOLOGY LETTERS
(2014)
Article
Oncology
Yao Cheng, Fan-Zhen Kong, Xiao-Feng Dong, Qin-Rong Xu, Qian Gui, Wei Wang, Hong-Xuan Feng, Wei-Feng Luo, Zong-En Gao, Guan-Hui Wu
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2017)