Journal
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
Volume 11, Issue 3, Pages 246-253Publisher
SPRINGER
DOI: 10.1007/s11910-011-0193-z
Keywords
Alzheimer's disease; Causal genes; Risk genes; Susceptibility factors; Genome-wide association study; Meta-analysis; Complex genetics
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Funding
- Cure Alzheimer Fund
- Michael J. Fox Foundation for Parkinson's Research
- German Federal Ministry for Education and Research (BMBF)
- Deutsche Forschungsgemeinschaft (DFG)
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After a decade of intensive investigation but only few replicable results, Alzheimer's disease (AD) genetics research is slowly picking up pace. This is mostly owing to the completion of several genome-wide association studies (GWAS), which have suggested the existence of over three dozen potential new AD susceptibility genes. Although only a handful of these could be confirmed in subsequent independent replication efforts to date, this success rate is still much higher than in the pre-GWAS era. This review provides a brief summary of the principal methodologic advances in genetics research of the past decade, followed by a description of the most compelling findings that these advances have unearthed in AD. The paper closes with a discussion of the persistent methodologic difficulties and challenges and an outlook on what we can expect to gain from the next 10 years of AD genetics research.
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