Letter
Clinical Neurology
Ariane Lewis, Steven Galetta
Summary: In their review, Sacco et al. discussed the clinical and pathophysiological relationship between migraine and stroke, while Scutelnic et al. highlighted the limited data on stroke in patients with migraine with aura, the unclear difference between aura changes and ischemic stroke, and the unclear relationship between atrial fibrillation and migraine. Ornello et al. agreed that clinical characteristics usually differentiate between typical migraine and migrainous infarction, and that the relationship between atrial fibrillation and migraine is complex but outside the scope of their review.
Letter
Clinical Neurology
Raffaele Ornello, Luciano A. Sposato, Simona Sacco
Summary: We agree with Scutelnic et al.'s comments regarding the clinical presentation of migrainous infarction and the differentiation between aura symptoms and ischemic symptoms. The relationship between atrial fibrillation and migraine with aura is complex and beyond the scope of our review, which focused on microembolism and its role in migraine and stroke pathophysiology.
Article
Medicine, General & Internal
Yusha Tang, Anjiao Peng, Bo Peng, Shixu He, Xia Zhao, Yuanfeng Zhu, Wanlin Lai, Tingting Song, Lei Chen
Summary: This study found a significant association between PFO and migraine without aura in Southwest China, especially when the shunt is large.
Article
Clinical Neurology
Elisabetta Del Zotto, Mario Grassi, Marialuisa Zedde, Andrea Zini, Anna Bersano, Carlo Gandolfo, Giorgio Silvestrelli, Claudio Baracchini, Paolo Cerrato, Corrado Lodigiani, Simona Marcheselli, Maurizio Paciaroni, Alessandra Spalloni, Manuel Cappellari, Massimo Del Sette, Anna Cavallini, Enrico Maria Lotti, Maria Luisa Delodovici, Mauro Gentile, Mauro Magoni, Marina Padroni, Cristiano Azzini, Maria Vittoria Calloni, Elisa Giorli, Massimiliano Braga, Paolo La Spina, Fabio Melis, Rossana Tassi, Valeria Terruso, Rocco Salvatore Calabro, Valeria Piras, Alessia Giossi, Sandro Sanguigni, Carla Zanferrari, Marina Mannino, Irene Colombo, Carlo Dallocchio, Patrizia Nencini, Valeria Bignamini, Alessandro Adami, Rita Bella, Rosario Pascarella, Zafer Keser, Alessandro Pezzini
Summary: By comparing the characteristics of 1,468 patients with sCeAD with two control groups, it was found that patients with sCeAD were more likely to have hypertension, migraine, and a family history of vascular disease, but less likely to have diabetes, high cholesterol, and obesity. Migraine without aura was also associated with sCeAD, and the risk increased with higher frequency of attacks. The use of preventive medications, especially beta-blockers, may reduce the risk of sCeAD.
ANNALS OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Ying-Yi Lu, Hao Qin, Chun-Ching Lu, Ming-Kung Wu, Cong-Liang Zhang, Chieh-Hsin Wu
Summary: The study found that patients with keloids have a higher risk of developing migraines compared to those without keloids, particularly among females and patients younger than 50 years old. This suggests that keloids could potentially be a predisposing risk factor for migraine development in adults.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Pamela M. Rist, Julie E. Buring, JoAnn E. Manson, Howard D. Sesso, Tobias Kurth
Summary: There is no significant association between a history of migraine in older women and an increased risk of COVID-19.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maram H. Alshareef, Bayan Hashim Alsharif
Summary: This study investigated the prevalence of primary headache disorders and associated risk factors in Makkah. The results showed a high prevalence of headaches, particularly among young adults. Age, chronic diseases, work, caffeine consumption, and smoking were found to be associated with headaches. The prevalence of headaches in Makkah has increased compared to previous studies.
Article
Clinical Neurology
V. De Giuli, M. Grassi, M. Locatelli, M. Gamba, A. Morotti, S. Bonacina, V. Mazzoleni, D. Pezzini, M. Magoni, R. Monastero, A. Padovani, A. Pezzini
Summary: Age is inversely associated with migraine, while women have over three times increased risk of migraine. Migraine is not associated with atrial fibrillation but is likely related to patent foramen ovale, especially in younger patients with fewer vascular risk factors and in women, particularly with migraine with aura.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Anesthesiology
Saeid Safiri, Hojjat Pourfathi, Arielle Eagan, Mohammad Ali Mansournia, Mohammad Taghi Khodayari, Mark J. M. Sullman, Jay Kaufman, Gary Collins, Haijiang Dai, Nicola Luigi Bragazzi, Ali-Asghar Kolahi
Summary: The Global Burden of Disease Study 2019 revealed an increase in the burden of migraine from 1990 to 2019, with significant intercountry differences. Migraine prevalence was higher in females and decreased with age after the 40 to 44 age group. Enhanced migraine care is necessary to increase awareness of risk factors and treatment strategies, particularly among young adults and middle-aged women, as well as to gather more data on migraines.
Article
Medicine, General & Internal
Vivek Nambiar, Manu Raj, Damodaran Vasudevan, Renjitha Bhaskaran, Remya Sudevan
Summary: The study reported low 1-year all-cause mortality among stroke patients, with predictors including age, baseline NIHSS score, and baseline mRS score.
Review
Medicine, General & Internal
Martin Ackah, Cynthia Osei Yeboah, Louise Ameyaw
Summary: This study aims to systematically review and meta-analyze the risk factors for in-hospital stroke mortality in sub-Saharan Africa, in order to provide targeted research. The pooled 30-day in-hospital stroke mortality rate will be analyzed, with meta-regression used to assess associated factors, as well as subgroup and sensitivity analyses conducted for further insights.
Review
Clinical Neurology
Shuyuan Zhang, Haixuan Liu, Tingwen Shi
Summary: The association between migraine and risk of stroke is inconsistent. Migraine is associated with a higher risk of total stroke and ischemic stroke (IS), but the association with hemorrhagic stroke (HS) is uncertain.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Marina Vives-Mestres, Amparo Casanova, Dawn C. Buse, Stephen Donoghue, Timothy T. Houle, Richard B. Lipton, Alec Mian, Kenneth J. Shulman, Serena L. Orr
Summary: The study describes patterns of perceived stress across stages of the migraine cycle, with three common variations identified: let down pattern, flat pattern, and stress as a trigger/symptom pattern. These patterns may offer insights for individualized treatment plans.
Article
Clinical Neurology
Adrian Scutelnic, Nedelina Slavova, Antonia Klein, Thomas Horvath, Sophie A. L. de Beukelaer, Marcel Arnold, Simon Jung, Christoph J. Schankin
Summary: Visual snow is a main symptom of visual snow syndrome, which is a disorder characterized by visual disturbances without any abnormal findings on ancillary investigations. We present a case series of patients who experienced visual snow during acute ischemic stroke. Our findings suggest that vascular lesions in areas of visual processing can cause the symptom of visual snow, but these lesions might only partially explain the pathophysiology of visual snow syndrome.
Article
Medicine, General & Internal
Guy S. Reeder, Nathaniel W. Taggart, Naser M. Ammash
Summary: Patients with patent foramen ovale can present in various ways, and the article discusses these presentations and their resolutions.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Clinical Neurology
Hebun Erdur, Joachim E. Weber, Anselm Angermaier, Stephan Kinze, Ali Sotoodeh, Claudia Gorski, Kerstin Bollweg, Stefanie Ernst, Farid Kandil, Janina Behrens, Ramanan Ganeshan, Anne Keysers, Malgorzata Kotlarz-Boettcher, Daniel Peters, Ludwig Schlemm, Kirsten Stangenberg-Gliss, Carl Witt, Beata Hennig, Katrin C. Reber, Udo Schneider, Christiana Franke, Ingo Schmehl, Hans-Beatus Straub, Agnes Floeel, Sarah Theen, Matthias Endres, Tobias Kurth, Heinrich J. Audebert
Summary: Implementing a multicomponent system-of-care can reduce the risk of poor outcomes in stroke patients.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ana Sofia Oliveira Goncalves, Jessica L. Rohmann, Marco Piccininni, Tobias Kurth, Martin Ebinger, Matthias Endres, Erik Freitag, Peter Harmel, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Reinhard Busse, Heinrich J. Audebert
Summary: The study assessed the cost-utility and cost-effectiveness of additional mobile stroke unit (MSU) dispatch in ischemic stroke patients eligible for recanalizing treatments. Results showed that MSU dispatch increased costs but also improved quality-adjusted life years (QALYs), and it was considered cost-effective according to internationally accepted thresholds.
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Tobias Kurth, Jessica L. Rohmann
Review
Economics
Ana Sofia Oliveira Goncalves, Sophia Werdin, Tobias Kurth, Dimitra Panteli
Summary: This review aimed to identify how studies deal with methodological challenges of repeated measurements in mapping algorithms using patient responses to questionnaires. The inconsistent use of methods to account for interdependent observations indicates a need for mapping guidelines and journal updates.
Article
Pediatrics
Stefanie Theuring, Mascha Kern, Franziska Hommes, Marcus A. A. Mall, Joachim Seybold, Frank P. P. Mockenhaupt, Toivo Glatz, Tobias Kurth
Summary: During the COVID-19 pandemic, children and adolescents worldwide have been disproportionately affected in their psychological health and wellbeing. A cohort study in Germany found that anxiety symptoms among school children decreased from June to August 2021, but increased again in September 2021. Factors such as gender, school type, household education and income level, and COVID-19 vaccination were significantly associated with reporting anxiety symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Jessica L. Rohmann, Rodrigo Huerta-Gutierrez, Heinrich J. Audebert, Tobias Kurth, Marco Piccininni
Summary: This study demonstrates the potential bias in using unadjusted stacked bar graphs to compare functional outcomes after stroke. By using IPT weighting to account for measured confounding, the researchers were able to present more accurate results.
EUROPEAN STROKE JOURNAL
(2023)
Article
Infectious Diseases
Annemarie Pantke, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Bjoern-Erik Ole Jensen, Christoph Stephan, Olaf Degen, Dirk Schuermann, Tobias Kurth, Viviane Bremer, Uwe Koppe
Summary: This study aimed to examine the incidence rates and predictive utility of established prognostic factors for the progression to AIDS among people living with HIV under clinical care. The study used data from two observational cohorts of people living with HIV in Germany and found that the rates of a first AIDS event have continuously declined, and health outcomes depend on CD4 count, viral load, and age but not on transmission mode.
Article
Genetics & Heredity
Corinna Grasemann, Jakob Hoppner, Peter Burgard, Michael M. Schundeln, Nora Matar, Gabriele Mueller, Heiko Krude, Reinhard Berner, Min Ae Lee-Kirsch, Fabian Hauck, Kerstin Wainwright, Sylvana Baumgarten, Janet Atinga, Jens J. Bauer, Eva Manka, Julia Korholz, Cordula Kiewert, Andre Heinen, Tanita Kretschmer, Tobias Kurth, Janna Mittnacht, Christoph Schramm, Christoph Klein, Holm Graessner, Olaf Hiort, Ania C. Muntau, Annette Grueters, Georg F. Hoffmann, Daniela Choukair
Summary: The transition process from paediatric/adolescent to adult medical care settings is crucial for the future health of adolescents with chronic diseases, especially in the context of rare diseases. This study presents a patient-focused transition pathway that can be adopted for different rare diseases, aiming to improve patients' health literacy and empower them through individualized training and counselling.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Health Care Sciences & Services
Jana Fehr, Marco Piccininni, Tobias Kurth, Stefan Konigorski
Summary: This study investigates the transportability of prediction models for cognitive impairment in different external settings. The results suggest that models predicting with causes of the outcome are more transportable than those predicting with consequences. Calibration performance is crucial when assessing model transportability to external settings.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Marco Piccininni, Tobias Kurth, Heinrich J. Audebert, Jessica L. Rohmann
Summary: The B_PROUD study aimed to evaluate the impact of mobile stroke unit (MSU) dispatch on ischemic stroke and transient ischemic attack (TIA) patients. However, a large proportion of patients did not receive MSU care despite being dispatched. The study found that receiving additional MSU care was associated with better functional outcomes compared to conventional care.
Article
Cardiac & Cardiovascular Systems
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, Tobias Kurth
Summary: Adding information on migraine with aura (MA) to cardiovascular disease (CVD) risk prediction models can improve risk prediction accuracy, but does not significantly improve risk stratification among women.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Kurth, Pamela M. Rist
Summary: The connection between migraine and cardiovascular disease is intricate and involves overlapping mechanisms like endovascular disturbances. Challenges in measuring migraine, differentiating causation from prediction, and understanding clinical implications emphasize the importance of further research to guide treatment and cardiovascular risk assessment for migraine sufferers.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Clinical Neurology
Marco Piccininni, Ralph Brinks, Jessica L. Rohmann, Tobias Kurth
Summary: This study used modern epidemiological methods to estimate the prevalence of never, active, and inactive migraine. The transition rate from active to inactive migraine increased after age 22.5 for women and 27.5 for men in Germany. The estimated prevalence of inactive migraine at age 60 was 25.7% for women in Germany and 16.5% globally, and 10.4% for men in Germany and 7.1% globally.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Health Care Sciences & Services
Vanessa Voelskow, Claudia Messner, Tobias Kurth, Amelie Busam, Toivo Glatz, Natalie Ebert
Summary: During the COVID-19 pandemic in Germany, telephone hotlines of local health authorities were overwhelmed with information requests. This study evaluated the use of a COVID-19-specific voicebot (CovBot) in these authorities and found that while it provided some relief to staff, it could not fully replace human assistance.
Article
Clinical Neurology
Eugen Schwabauer, Marco Piccininni, Erik Freitag, Martin Ebinger, Frederik Geisler, Peter Harmel, Annegret Hille, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Tobias Kurth, Jessica L. Rohmann, Matthias Endres, Frieder Schlunk, Joachim Weber, Matthias Wendt, Heinrich J. Audebert
Summary: The study found that dispatching Mobile Stroke Units (MSUs) led to a reduction in systolic blood pressure (sBP) and shorter dispatch-to-imaging time compared to conventional ambulance care for patients with acute intracerebral haemorrhage (ICH). However, there was no significant difference in other outcomes, including 7-day mortality and favorable outcome.
EUROPEAN STROKE JOURNAL
(2023)