Article
Behavioral Sciences
Aijun Liu, Yongcheng Jiao, Shaohui Zhang, Haibo Kong
Summary: Bilateral posteroventral GPi DBS can significantly alleviate motor tics and depressive symptoms in GTS patients, but vocal tics and other psychiatric symptoms may worsen without statistical difference during the follow-up period.
BRAIN AND BEHAVIOR
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Article
Neurosciences
Petra Heiden, Mauritius Hoevels, Dilruba Bayram, Juan C. Baldermann, Thomas Schueller, Daniel Huys, Veerle Visser-Vandewalle, Pablo Andrade
Summary: This study analyzed the connectivity profiles of different DBS targets for GTS and found significant differences in the connectivity profiles of standard targets. The pvGPi showed the strongest connection to the sensorimotor cortex, while the amGPi showed the strongest connection to the prefrontal cortex. Using probabilistic tractography based on patient data and a normative connectome revealed differences in connectivity profiles.
Article
Clinical Neurology
Takashi Tsuboi, Marc Charbel, David T. Peterside, Mohit Rana, Ahmad Elkouzi, Wissam Deeb, Adolfo Ramirez-Zamora, Janine Lemos Melo Lobo Jofili Lopes, Leonardo Almeida, Pamela R. Zeilman, Robert S. Eisinger, Kelly D. Foote, Lela Okromelidze, Sanjeet S. Grewal, Michael S. Okun, Erik H. Middlebrooks
Summary: This study aimed to identify anatomical regions related to stimulation-induced dyskinesia (SID) in PD patients after pallidal DBS and analyze the connectivity associated with SID. The results showed that SID VTAs were primarily located in the dorsal GPi/GPe and had higher structural connectivity to certain cortical regions compared to non-SID VTAs. Differences in connectivity between motor-related cortices and subcortical regions may explain the presence or absence of SID.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Vanessa M. Holanda, Robert Stephen Eisinger, Leonardo Almeida, Takashi Tsuboi, Huimin Wang, Michael S. Okun, Wissam Deeb, Addie Patterson, Aparna Wagle Shukla, Janine Lobo Lopes, Kelly Douglas Foote
Summary: This study aimed to evaluate the evolution of GPi DBS targeting in patients with dystonia or PD. During 15 years of follow-up, lead locations in the PD group migrated laterally, posteriorly, and dorsally, whereas leads in the dystonia group showed a trend in the dorsal direction. The evolving target may result from improvements in targeting techniques and clinical feedback intraoperatively and post-operatively.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Fengqiao Sun, Xiaohua Zhang, Sheng Dong, Yuqing Zhang, Jiping Li, Yunpeng Wang, Jin Zhu
Summary: The study showed that low-frequency DBS is an effective and practical treatment for refractory TS, with comparable efficacy to high-frequency DBS.
Article
Clinical Neurology
Zhitong Zeng, Linbin Wang, Weikun Shi, Lu Xu, Zhengyu Lin, Xinmeng Xu, Peng Huang, Yixin Pan, Zhonglue Chen, Yun Ling, Kang Ren, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study found that subthalamic nucleus (STN) deep brain stimulation (DBS) is more effective than unilateral globus pallidus interna (GPi) DBS in treating motor symptoms. STN DBS improves symptoms on both sides of the body, while GPi DBS mainly affects the contralateral side.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Robert S. Eisinger, Michael S. Okun, Stephanie Cernera, Jackson Cagle, Matthew Beke, Adolfo Ramirez-Zamora, B. Hope Kim, Daniel A. N. Barbosa, Liming Qiu, Pavan Vaswani, Whitley W. Aamodt, Casey H. Halpern, Kelly D. Foote, Aysegul Gunduz, Leonardo Almeida
Summary: Weight loss in Parkinson's disease patients accelerates before death. Patients who underwent deep brain stimulation surgery gained weight, and higher post-operative weight correlates with longer survival.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Wentao Zheng, Gaoquan Lv, Yunwei Lu, Jiayu Liu, Qingpei Hao, Hu Ding, Yezu Liu, Ruen Liu
Summary: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is a safe and effective treatment approach for Meige syndrome, improving motor function and quality of life without cognitive and mood side effects.
Article
Clinical Neurology
Hong Tian, Bo Zhang, Yanbing Yu, Xueke Zhen, Li Zhang, Yue Yuan, Liang Wang
Summary: DBS of the posterior GPi may lead to better clinical outcomes in treating primary Meige syndrome, and higher GPi neuronal activity, particularly in the ventral part, can be utilized as a biomarker to guide DBS electrode implantation during surgery.
Article
Clinical Neurology
Takashi Tsuboi, Janine Lemos Melo Lobo Jofili Lopes, Kathryn Moore, Bhavana Patel, Joseph Legacy, Adrianna M. Ratajska, Dawn Bowers, Robert S. Eisinger, Leonardo Almeida, Kelly D. Foote, Michael S. Okun, Adolfo Ramirez-Zamora
Summary: Globus pallidus internus deep brain stimulation in Parkinson's disease patients showed sustained long-term benefits in tremor scores, motor complications, but gradual worsening in HRQoL and cardinal motor symptoms other than tremor in the long term. Benefits in tremor and dyskinesia are expected to be most persistent following bilateral GPi DBS implantation.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Florian Lange, Carolina Soares, Jonas Roothans, Rita Raimundo, Hazem Eldebakey, Benedikt Weigl, Robert Peach, Christine Daniels, Thomas Musacchio, Jens Volkmann, Maria Jose Rosas, Martin M. Reich
Summary: Deep brain stimulation is effective for alleviating dystonia motor symptoms, but delayed symptom control and lack of therapeutic biomarkers and optimal programming settings complicate postoperative management. This study prospectively tested machine-predicted programming settings and found that they significantly reduced dystonia symptoms compared to clinical programming.
Review
Clinical Neurology
Roberta Bonomo, Antonio E. Elia, Giulio Bonomo, Luigi M. Romito, Caterina Mariotti, Grazia Devigili, Roberto Cilia, Riccardo Giossi, Roberto Eleopra
Summary: In patients with Huntington's disease, deep brain stimulation in the globus pallidus internus can lead to significant improvements in disease rating and motor symptoms, while effectively reducing chorea scores. Further studies are needed to identify reliable criteria to guide patient selection for DBS therapy.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Kevin W. McCairn, Robert S. Turner
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Neurosciences
Kevin W. McCairn, Yuji Nagai, Yukiko Hori, Taihei Ninomiya, Erika Kikuchi, Ju-Young Lee, Tetsuya Suhara, Atsushi Iriki, Takafumi Minamimoto, Masahiko Takada, Masaki Isoda, Masayuki Matsumoto
Article
Neuroimaging
Hang Joon Jo, Kevin W. McCairn, William S. Gibson, Paola Testini, Cong Zhi Zhao, Krzysztof R. Gorny, Joel P. Felmlee, Kirk M. Welker, Charles D. Blaha, Bryan T. Klassen, Hoon-Ki Min, Kendall H. Lee
NEUROIMAGE-CLINICAL
(2018)
Article
Clinical Neurology
Kevin W. McCairn, Maya Bronfeld, Katya Belelovsky, Izhar Bar-Gad
Article
Neurosciences
Yulia Worbe, Nicolas Baup, David Grabli, Marion Chaigneau, Stephanie Mounayar, Kevin McCairn, Jean Feger, Leon Tremblay
Article
Neurosciences
Kevin W. McCairn, Robert S. Turner
JOURNAL OF NEUROPHYSIOLOGY
(2009)
Article
Neurosciences
Yaara Erez, Hadass Czitron, Kevin McCairn, Katya Belelovsky, Izhar Bar-Gad
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Kevin W. McCairn, Atsushi Iriki, Masaki Isoda
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Kevin W. McCairn, Atsushi Iriki, Masaki Isoda
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Kevin W. McCairn, Atsushi Iriki, Masaki Isoda
Article
Multidisciplinary Sciences
Hye Ran Park, In Hyang Kim, Hyejin Kang, Kevin W. McCairn, Dong Soo Lee, Bung-Nyun Kim, Dong Gyu Kim, Sun Ha Paek
Article
Clinical Neurology
D Grabli, K McCairn, EC Hirsch, Y Agid, J Féger, C Francois, L Tremblay
Article
Clinical Neurology
C François, D Grabli, K McCairn, C Jan, C Karachi, EC Hirsch, J Féger, L Tremblay
Article
Clinical Neurology
Alex K. Wu, Kevin W. McCairn, Gabriel Zada, Tiffany Wu, Robert S. Turner
JOURNAL OF NEUROSURGERY
(2007)