Journal
CURRENT MOLECULAR MEDICINE
Volume 14, Issue 1, Pages 174-184Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566524013666131121115656
Keywords
Apoptosis; chemokine (C-X-C motif) ligand 12 (CXCL12); CXC chemokine receptor types 4 (CXCR4); EMT (epithelial mesenchymal transition); shRNA; triple negative breast cancer; visceral organ specific metastases.
Categories
Funding
- Major State Basic Research Development Program [2011CB707705]
- Projects of International Cooperation and Exchanges NSFC [81320108015]
- National Natural Science Foundation of China [30973377, 31271068]
- Key Laboratory of Breast Cancer Prevention and Treatment of Guangdong Province, P.R. China
Ask authors/readers for more resources
Triple negative breast cancer is known for its visceral metastasis. We have found that CXCR4 is overexpressed in triple negative breast cancer and is associated with visceral metastasis. We further investigated whether CXCR4 is a prognostic factor affecting survival following visceral metastasis in breast cancer patients. Our results indicate that increased CXCR4 expression among breast cancer patients with visceral metastasis was positively correlated with poor overall survival (P< 0.001). Silencing of CXCR4 was associated with a decrease in the tumorigenic properties of MDA-MB-231 breast cancer cells, caused reversion of EMT and suppression of MMP-9, increased apoptosis, and caused a reduced incidence of tumor lung metastasis in mice. These results are indicative of CXCR4 having a predictive role in patients with visceral metastasis and indicate that shRNA knock down of CXCR4 might be a novel therapeutic strategy to prevent breast cancer metastasis when CXCR4 is overexpressed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available