Article
Pharmacology & Pharmacy
Neha Datta, Charlotte Johnson, Dina Kao, Pratik Gurnani, Cameron Alexander, Christos Polytarchou, Tanya M. Monaghan
Summary: An emerging shared pathophysiology across microbiota-gut-brain axis disorders is aberrant miRNA expression, which may represent novel therapeutic targets. miRNAs, important transcriptional repressors of gene expression, regulate the integrity of the intestinal epithelial and blood-brain barriers and serve as a communication channel between the gut microbiome and the host. Understanding the mode of action, therapeutic strategies, and delivery mechanisms of miRNAs is pivotal in translating their clinical applications.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Farah Omran, Ioannis Kyrou, Faizel Osman, Ven Gee Lim, Harpal Singh Randeva, Kamaljit Chatha
Summary: Cardiovascular diseases (CVDs) are a major healthcare burden worldwide. Early detection is crucial for prevention and treatment, and biomarkers play a critical role. Traditional cardiac biomarkers have been replaced by new ones, but their limitations remain. Further research is needed to evaluate the value of future cardiac biomarkers in improving CVD detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sara G. Dosil, Ana Rodriguez-Galan, Francisco Sanchez-Madrid, Lola Fernandez-Messina
Summary: MicroRNAs (miRNAs) play a crucial role in regulating gene expression in both normal and disease states. While there is growing evidence supporting the therapeutic potential of restoring miRNA levels in pre-clinical models, its translation to clinical applications is still limited. This review provides an overview of the current knowledge on miRNAs as T-cell targeting immunotherapeutic tools, including recent advances in miRNA delivery strategies, clinical trials, and future perspectives in RNA interference technologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jasvinder Singh Bhatti, Naina Khullar, Rajesh Vijayvergiya, Umashanker Navik, Gurjit Kaur Bhatti, P. Hemachandra Reddy
Summary: Heart disorders are a major issue in aging, with mitochondria playing a critical role in their development. Both environmental and genetic factors are important in controlling mitochondrial functions. Aging hearts are more prone to heart-related complications compared to younger hearts. While advanced technologies and procedures are used for prevention and treatment, there is still a need for a novel and effective strategy for timely diagnosis and treatment.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Jawiarczyk-Przybylowska, Justyna Kuliczkowska-Plaksej, Katarzyna Kolackov, Agnieszka Zembska, Jowita Halupczok-Zyla, Malgorzata Rolla, Michal Miner, Marcin Kaluzny, Marek Bolanowski
Summary: The study reveals that the polymorphisms of the FTO gene are associated with lipid metabolism and an increased risk of cardiovascular diseases in patients with acromegaly. Furthermore, these polymorphisms also have an impact on IGF-1 synthesis. Larger scale investigations are needed for more precise evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Mariangeli Monero-Paredes, Roberto Feliu-Maldonado, Kelvin Carrasquillo-Carrion, Pablo Gonzalez, Igor B. Rogozin, Abiel Roche-Lima, Jorge Duconge
Summary: This study aimed to assess the possible interaction between genetic biomarkers linked to cardiovascular diseases and those associated with clopidogrel resistance among admixed Caribbean Hispanics. The results showed no genetic loci with a dual predictive role for the risk of cardiovascular disease severity and clopidogrel resistance in this population.
Review
Pathology
Emad Gamil Khidr, Ahmed I. Abulsoud, Ayman A. Doghish, Hesham A. El-Mahdy, Ahmed Ismail, Mohammed S. Elballal, Omnia M. Sarhan, Sherif S. Abdel Mageed, Elsayed G. E. Elsakka, Samy Y. Elkhawaga, Ahmed A. El-Husseiny, Nourhan M. Abdelmaksoud, Aya A. El-Demerdash, Reem K. Shahin, Heba M. Midan, Mahmoud A. Elrebehy, Osama A. Mohammed, Logyna A. Abulsoud, Ahmed S. Doghish
Summary: miRNAs play important roles in cardiac physiological and pathological processes by regulating gene expression. They can influence cardiac homeostasis and participate in modulatory signaling pathways under various cardiac pathological conditions. miRNAs may serve as potential therapeutic targets for treating cardiac diseases.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Peripheral Vascular Disease
Leslie Marisol Lugo-Gavidia, Dylan Burger, Vance B. Matthews, Janis M. Nolde, Marcio Galindo Kiuchi, Revathy Carnagarin, Dennis Kannenkeril, Justine Chan, Anu Joyson, Lakshini Y. Herat, Omar Azzam, Markus P. Schlaich
Summary: Microparticles are small cell vesicles derived from the cell membrane, with growing evidence linking them to cardiovascular disease through inflammation, endothelial function, and thrombosis. Research on the direct causal link between microparticle release and their implications on physiological and pathological conditions is ongoing.
Review
Medicine, Research & Experimental
Huan Zhang, Xueqi Wan, Jinfan Tian, Ziyu An, Libo Liu, Xin Zhao, Yuquan Zhou, Lijun Zhang, Changjiang Ge, Xiantao Song
Summary: This review presents the cardioprotective effects of mesenchymal stem cell-derived exosomes and explores the underlying molecular mechanisms. It also discusses several efficient approaches for delivering exosomes to the heart in clinical applications and comments on the advantages and disadvantages of each method.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Paula Gonzalez Rojo, Cristina Perez Ramirez, Jose Maria Galvez Navas, Laura Elena Pineda Lancheros, Susana Rojo Tolosa, Maria del Carmen Ramirez Tortosa, Alberto Jimenez Morales
Summary: This study evaluated the association between VDR gene polymorphisms and the risk of cardiovascular diseases in a Caucasian population. The results showed that certain variations in the VDR gene are associated with increased risk of cardiovascular diseases, while others have no effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ivana Skrlec, Zrinka Biloglav, Jasminka Talapko, Snjezana Dzijan, Danijela Daus-Sebedak, Vera Cesar
Summary: This study investigated the association between MTNR1B gene polymorphisms, chronotype, and susceptibility to myocardial infarction. The case-control study included 199 myocardial infarction patients and 198 control participants without previous cardiovascular diseases, who were genotyped for MTNR1B polymorphisms. Chi-square tests revealed no significant association between allele and genotype distribution in myocardial infarction patients and controls. Additionally, there was no association between MTNR1B polymorphisms and chronotype in myocardial infarction patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Celia Castano-Amores, Xando Diaz-Villamarin, Ana Maria Perez-Gutierrez, Alba Antunez-Rodriguez, Ana Pozo-Agundo, Eduardo Moreno-Escobar, Jesus Gabriel Sanchez-Ramos, Luis Javier Martinez-Gonzalez, Cristina Lucia Davila-Fajardo
Summary: Beta-blockers are commonly used to treat cardiovascular diseases, but genetic differences may affect individual responses. The ADRB1 Arg389Gly variant is the most studied genetic polymorphism in relation to bisoprolol response, but results have been inconclusive. Further studies are needed to explore the impact of genetic variants on bisoprolol response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Melisa Cetinkaya, Yusuf Baran
Summary: Non-coding RNAs have crucial regulatory roles in cellular processes, particularly in gene expression. They have emerged as novel targets for anti-cancer drug development, with microRNAs being extensively studied in cancer biology and some microRNA-based therapeutics reaching clinical studies. Long non-coding RNAs are also gaining importance as potential therapeutic targets for cancer therapy. This chapter discusses the strategies and significance of targeting microRNAs and long non-coding RNAs, as well as clinical and preclinical studies involving microRNA and long non-coding RNA-based cancer therapeutics. Additionally, the importance of delivery strategies for effective non-coding RNA-based cancer therapeutics is highlighted.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yang Zhong, Xueping Zeng, Yuling Zeng, Lulu Yang, Juanjuan Peng, Lingzhi Zhao, Young-tae Chang
Summary: Cardiovascular diseases, including atherosclerosis, thrombosis, myocardial/cerebral infarction, and ischemia-reperfusion injury, are the leading cause of disability and death globally. The development of nanotechnology has provided opportunities for the precise delivery of active agents for the diagnosis and therapy of these diseases. This article summarizes the design strategies and significance of engineered nanomaterials in the diagnosis and treatment of diverse cardiovascular diseases, and prospects the challenges and research targets in this field.
Review
Oncology
Yongshu Li, Winnie Wailing Tam, Yuanyuan Yu, Zhenjian Zhuo, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Xiaokang Wang, Weijing Wang, Yongyi Li, Yanyang Tu, Yunhua Gao
Summary: Biomarkers are detectable molecules that can indicate specific diseases, and nucleic acid aptamers have emerged as a powerful tool in biomarker discovery. SELEX-based methods have been developed to construct aptamers for discovering new biomarkers in different cell locations, and SOMAScan is a multiplexed protein biomarker detection technology. These methods have greatly accelerated biomarker discovery in various diseases.
BIOMARKER RESEARCH
(2023)
