Article
Biochemistry & Molecular Biology
Botle Precious Setlai, Rodney Hull, Meshack Bida, Chrisna Durandt, Thanyani Victor Mulaudzi, Aristotelis Chatziioannou, Zodwa Dlamini
Summary: Immune response is crucial for patient prognosis and response to cancer treatment. Tumors evade immune surveillance by altering antigen processing pathways and the tumor microenvironment. This review highlights the molecular signaling pathways involved in immune suppression and how cancer cells manipulate antigen processing to escape immune surveillance. Additionally, the review explores the potential use of these pathways in precision medicine and understanding drug resistance.
Review
Biochemistry & Molecular Biology
Yun-yu Zhang, Bo-tao Ning
Summary: Sepsis is a life-threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection. Advanced understanding of host-microorganism interaction has led to new definitions and therapeutic approaches. Research focus has shifted from pathogenicity of microorganisms to the molecular basis of host responses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Pharmacology & Pharmacy
Ziba Lotfi, Shiva Najjary, Fariba Lotfi, Mohammad Amini, Amir Baghbanzadeh, Darya Javad Rashid, Elmira Roshani Asl, Behzad Baradaran, Ahad Mokhtarzadeh
Summary: Pancreatic cancer is a deadly cancer with low survival rates, mainly due to relapse and resistance to treatment. Tumors have a high desmoplastic stroma, affecting growth and spread. Genetic studies show common molecular features and mutations in key genes in PC development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carline Chaves-Almagro, Johanna Auriau, Alizee Dortignac, Pascal Clerc, Hubert Lulka, Simon Deleruyelle, Fabrice Projetti, Jessica Nakhle, Audrey Frances, Judit Berta, Veronique Gigoux, Daniel Fourmy, Marlene Dufresne, Anne Gomez-Brouchet, Julie Guillermet-Guibert, Pierre Cordelier, Bernard Knibiehler, Ralf Jockers, Philippe Valet, Yves Audigier, Bernard Masri
Summary: This study investigated the expression and protumoral function of apelin and its receptor APJ in human pancreatic adenocarcinoma. It was found that apelin and APJ were co-expressed by tumor cells in the invasive stage, and apelin promoted cancer cell proliferation, migration, and glucose uptake. Blocking the apelin receptor reduced cancer cell proliferation and pancreatic tumor burden.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jia Guo, Hanyi Zhang, Wenri Lin, Lixia Lu, Juan Su, Xiang Chen
Summary: This review article provides an overview of the epidemiology, clinical subtypes, pathophysiology, and comorbidities of psoriasis. It discusses the signaling pathways, metabolic and epigenetic mechanisms, as well as current treatment options and potential mechanisms of disease recurrence.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Oncology
Ntombikayise Xelwa, Geoffrey Patrick Candy, John Devar, Jones Omoshoro-Jones, Martin Smith, Ekene Emmanuel Nweke
Summary: Pancreatic cancer is highly lethal and chemoresistant, with growth factors playing a crucial role in its resistance to treatment. The interaction between the tumor microenvironment and chemoresistance, as well as potential therapeutic targeting of these factors, are important areas of study.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xia Li, Chentao Li, Wanying Zhang, Yanan Wang, Pengxu Qian, He Huang
Summary: Aging is characterized by systemic chronic inflammation and its associated consequences. Inflammation and senescence form a vicious cycle, with senescent cells promoting chronic inflammation and inflammation accelerating cellular senescence. The persistence of elevated inflammation levels in organs leads to organ damage and age-related diseases. Understanding the mechanisms of inflammation and aging is crucial for developing effective anti-aging strategies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Silviu Stanciu, Florentina Ionita-Radu, Constantin Stefani, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Maria Greabu, Alexandra Ripszky Totan, Mariana Jinga
Summary: Pancreatic cancer, although relatively rare, is becoming a leading cause of cancer death. Various risk factors, both modifiable and non-modifiable, contribute to its pathogenesis. Chronic inflammation plays a crucial role in the development of pancreatic cancer. The PI3K/AKT/mTOR signaling pathway is important in cell growth, survival, and motility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Juan Luo, Hailin Zou, Yibo Guo, Tongyu Tong, Liping Ye, Chengming Zhu, Liang Deng, Bo Wang, Yihang Pan, Peng Li
Summary: Breast cancer is the most common malignant tumor worldwide and a leading cause of cancer-related deaths among women. SRC family kinases (SFKs), a type of non-receptor tyrosine kinase, have been found to play crucial roles in breast cancer progression. This review provides an overview of SRC kinase and its relevant functions in various subtypes of breast cancer, and highlights the role of SRC-mediated substrate phosphorylation in breast cancer signaling transductions. Furthermore, the progress of SRC-based targeted therapies and potential future directions in breast cancer are discussed.
BREAST CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Heidi E. Roth, Aline De Lima Leite, Nicolas Y. Palermo, Robert Powers
Summary: This study focuses on pancreatic cancer and identifies the human protein DNAJA1 as a potential therapeutic target. Through NMR structure determination and drug screening, the structure of DNAJA1, the binding sites of protein and ligand, and potential binding partners are identified. The findings suggest a crucial role of DNAJA1 in cellular oncogenesis and pancreatic cancer.
Article
Genetics & Heredity
Matthew P. Vandermeulen, Paul Cullen
Summary: Phenotypes can change in different environments through the regulation of signaling networks. This study explored the regulatory network controlling a complex yeast phenotype using Gene by Environment Interactions (GEIs) analysis. The results showed that regulatory pathways can play different roles and even reverse roles in different environments. This led to the identification of an underappreciated pathway as a major regulator. Environmental differences caused changes in pathway interactions, such as conditional redundancy and conditional cross-pathway regulation. The study suggests that studying biological processes under diverse environments captures a more complete picture of regulatory pathways and GEI analysis is a powerful method to explore the regulatory basis of complex phenotypes.
Review
Cell Biology
Chao-Hui Chang, Siim Pauklin
Summary: Pancreatic cancer is a leading cause of cancer-related deaths worldwide due to delayed diagnosis and limited treatments. Pancreatic ductal adenocarcinoma accounts for more than 90% of all pancreatic cancers, with extracellular vesicles playing a crucial role in regulating tumor growth and metastasis. Understanding the factors in EVs derived from pancreatic ductal adenocarcinoma can provide insights into potential early diagnosis and therapeutic strategies against this deadly cancer.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang
Summary: This article reviews the importance of thioredoxin (Trx) in regulating cancer-related signaling pathways and its potential therapeutic opportunities. Research has shown that Trx participates in multiple signaling pathways that influence cancer development and treatment by modulating the dynamic changes in protein structure and function. Future research directions include further exploring Trx-related signaling pathways and their upstream and downstream regulatory proteins, as well as developing novel anticancer drugs targeting the Trx signaling pathways.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Health Care Sciences & Services
Longhao Sun, Yang Zhang, Tiantian Yang, Junhang Chen, Xuebin Zhang, Xiaoyu Liang
Summary: Regulatory T cell infiltration is associated with tumor development and prognosis in pancreatic ductal adenocarcinoma. This study reveals that insulin-like growth factor binding protein 2 (IGFBP2) is associated with regulatory T cell accumulation and promotes disease progression in PDAC by inducing immunosuppressive tumor microenvironment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Bingxin Zheng, Yixin Zheng, Ningning Zhang, Yi Zhang, Baodong Zheng
Summary: This study aimed to evaluate the anti-pancreatic cancer effects of flavonoids in Plumula Nelumbinis. Rhoifolin was found to be the most abundant component and showed the maximum inhibitory effect on cell proliferation. Rhoifolin inhibited cell migration and invasion, and increased the antioxidant capacity. The study also showed that rhoifolin regulated the AKT/JNK/caspase-3 and TGF-beta 2/SMAD2 signaling pathways.
SCIENTIFIC REPORTS
(2022)
