Journal
CURRENT MEDICINAL CHEMISTRY
Volume 19, Issue 23, Pages 4006-4013Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986712802002536
Keywords
Atherosclerosis; CCL2; 3,4-DHPEA-EDA; endothelial cells; E-selectin; ICAM; inflammation; LPS; poliphenols; TNF-alpha; VCAM
Funding
- National Project Ricerca e Innovazione per l'Olivicoltura Meridionale (RIOM) from Italian Ministry of Agriculture
- Calabrian Regional government
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Diets in which fat is significantly provided by olive oil and are relatively rich in vegetables, have been associated with a low incidence of cardiovascular diseases, mostly due to the presence of several phenolic compounds which have anti-oxidant and anti-inflammatory properties. ([1]). In this work, we describe the anti-inflammatory effect of 3,4-DHPEA-EDA in a cell model that we developed to mimic inflammatory injury of endothelium. This was based on the production of the proinflammatory chemokine CCL2, following in vitro stimulation of primary human endothelial cells. Pre-treatment of cells with 3,4-DHPEA-EDA resulted in a dose-dependent inhibition of CCL2 secretion. The effect of 3,4-DHPEA-EDA on CCL2 expression was observed at the transcriptional level. Functional data have shown that 3,4-DHPEA-EDA diminished monocyte adhesion to HUVECs. These results point on the use of 3,4-DHPEA-EDA as a novel drug aimed to prevent or reduce inflammation of endothelium.
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