Journal
CURRENT MEDICINAL CHEMISTRY
Volume 19, Issue 17, Pages 2738-2759Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986712800609698
Keywords
Metal homeostasis; toxicity; transport
Funding
- Polish State Committee for Scientific Research [KBN N N204 146537, KBN N N204 183340]
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In this work, latest reports about metal toxicity, transport and homeostasis have been thoroughly described and discussed. Although diseases associated with transport and homeostasis abnormalities are those of great interest, still a variety of the phenomena associated with these processes are under debate. In this paper, we try to summarize the newest theses on this topic, presenting contradictory points of view. We focus on toxic and essential metal pathways crossing and try to follow the exact metal binding molecules within the body and provide insight into the transport mechanism. Special attention is given to the mechanism of action of lately investigated metal transporters.
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