Review
Biochemistry & Molecular Biology
Francesco Balestri, Roberta Moschini, Umberto Mura, Mario Cappiello, Antonella Del Corso
Summary: This article introduces the role of aldose reductase (AKR1B1) in diabetic complications and the development of its inhibitors. Currently, the synthesized inhibitors have failed to become drugs for the treatment of diabetic complications. The article proposes a differential inhibition approach that has the potential to become a new generation of inhibitors.
Review
Biochemistry & Molecular Biology
Himangshu Sonowal, Kota V. Ramana
Summary: Aldose Reductase (AR) is an enzyme involved in the polyol pathway of glucose metabolism and has been associated with the development of secondary diabetic complications as well as inflammatory disorders and cancer. Research is currently focused on exploring the potential therapeutic use of AR inhibitors beyond diabetic complications.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lidia Ciccone, Giovanni Petrarolo, Francesca Barsuglia, Carole Fruchart-Gaillard, Evelyne Cassar Lajeunesse, Adeniyi T. Adewumi, Mahmoud E. S. Soliman, Concettina La Motta, Elisabetta Orlandini, Susanna Nencetti
Summary: ALR2 inhibitors with antioxidant properties can prevent or delay the progression of diabetic complications by inhibiting enzyme activity and enhancing antioxidant efficacy.
Review
Chemistry, Medicinal
Sapna Thakur, Sonu Kumar Gupta, Villayat Ali, Priyanka Singh, Malkhey Verma
Summary: Diabetes mellitus leads to elevated glucose levels in the blood, causing overexpression of aldose reductase and subsequent complications such as retinopathy, neuropathy, and nephropathy. Metabolic disorders related to glucose metabolism, such as sorbitol accumulation, overproduction of NADH, and excessive fructose production, are the main causes of diabetic pathogenesis and its complications.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Mohd Saeed, Munazzah Tasleem, Ambreen Shoaib, Nadiyah M. Alabdallah, Md. Jahoor Alam, Zeina El Asmar, Qazi Mohammad Sajid Jamal, Fevzi Bardakci, Irfan Ahmad Ansari, Mohammad Javed Ansari, Feng Wang, Riadh Badraoui, Dharmendra Kumar Yadav
Summary: This study focuses on the role of Shikonin and its pharmacophores in inhibiting the action of aldose reductase. Various computational biology techniques, as well as in vitro activity and kinetic studies, were used to investigate the inhibitory activity of Shikonin against aldose reductase.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Analytical
Thomas Soranzo, Awatef Ben Tahar, Ayman Chmayssem, Marc Zelsmann, Pankaj Vadgama, Jean-Luc Lenormand, Phillipe Cinquin, Donald K. Martin, Abdelkader Zebda
Summary: In this study, the enzyme aldehyde reductase was synthesized and cloned from a human gene. Spectrophotometric and electrochemical measurements demonstrated that aldehyde reductase can catalyze the reduction of glucose to sorbitol and significantly decrease the electrocatalytic oxidation current of NADPH after glucose addition. This work provides insights into the construction of an efficient electrochemical glucose biosensor.
Article
Biochemistry & Molecular Biology
D. Jayabal, S. Jayanthi, R. Thirumalaisamy, R. Karthika, Muhammad Nasir Iqbal
Summary: In this study, the antidiabetic potential of 40 phytocompounds and three antidiabetic pharmaceuticals was compared and validated against hyperglycemic target proteins. Several phytocompounds showed good binding affinity towards diabetes-related proteins and exhibited better pharmacological and pharmacokinetic properties compared to the pharmaceuticals. DFT analysis revealed that these phytocompounds had higher orbital energies than the commercial drug. MD simulation and MMGBSA analysis indicated that phytocompounds had stronger affinities for binding to the target proteins than the antidiabetic pharmaceuticals. The study proved that proanthocyanidins and silymarin act as novel antidiabetic compounds, but clinical trials are needed to evaluate their clinical relevance.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Ana L. Becerril-Sanchez, Baciliza Quintero-Salazar, Octavio Dublan-Garcia, Hector B. Escalona-Buendia
Summary: Honey has been used since ancient times for its sensory, nutritional, and therapeutic properties, which are related to its physical and chemical composition. Phenolic compounds play a significant role in honey, influencing its antioxidant activity, botanical-geographical origin, and sensory characteristics. Researchers are increasingly interested in the study of phenolic compounds and their impact on honey's biological and functional activity.
Article
Biochemistry & Molecular Biology
Nagesh Patnam, Kishan Chevula, Prasad Chennamsetti, Balaswamy Aleti, Aruna Kumari Kotha, Vijjulatha Manga
Summary: A series of novel aryl benzylidenethiazolidine-2,4-dione based 1,2,3-triazoles were synthesized using a straightforward route. The new compounds were tested for in vitro antidiabetic activity by inhibiting the aldose reductase enzyme. The results showed that several compounds exhibited potent activity, with higher binding affinities than the reference compound Sorbinil according to molecular docking studies.
MOLECULAR DIVERSITY
(2023)
Review
Biochemistry & Molecular Biology
Mahavir Singh, Aniruddh Kapoor, Aruni Bhatnagar
Summary: Aldose reductase (AR) plays a key role in the development of diabetic complications, and its inhibition may have both beneficial and harmful effects. Research suggests that inhibition of AR could modify the effects of cardiovascular disease, asthma, neuropathy, sepsis, and cancer.
Article
Chemistry, Multidisciplinary
Aqeel Imran, Muhammad Tariq Shehzad, Syed Jawad Ali Shah, Mark Laws, Taha al-Adhami, Khondaker Miraz Rahman, Imtiaz Ali Khan, Zahid Shafiq, Jamshed Iqbal
Summary: Diabetic complications are caused by overexpression of aldose reductase, leading to oxidative stress and formation of advanced glycation end products. Current aldose reductase inhibitors have failed due to toxicity and poor pharmacokinetic profiles. This study developed thiosemicarbazone derivatives as selective inhibitors of ALR2 with antioxidant and antiglycation potential. Among the synthesized compounds, 3c showed strong and selective inhibition of ALR2, as well as good antioxidant and antiglycative properties.
Article
Biology
Francesco Balestri, Giulio Poli, Lucia Piazza, Mario Cappiello, Roberta Moschini, Giovanni Signore, Tiziano Tuccinardi, Umberto Mura, Antonella Del Corso
Summary: The increased glucose levels in diabetes lead to metabolic alterations and the onset of diabetic complications. Blocking the polyol pathway through aldose reductase inhibition is considered a valuable strategy. However, the enzyme also has a beneficial effect in cells, so the use of differential inhibitors has been proposed to preserve its detoxifying action. This study analyzed derivatives of catechins as potential differential inhibitors of aldose reductase and found promising inhibitory effects.
Article
Cell Biology
Yentel Mateo-Otero, Estel Vinolas-Verges, Marc Llavanera, Jordi Ribas-Maynou, Jordi Roca, Marc Yeste, Isabel Barranco
Summary: The study found that aldose reductase B1 is abundantly expressed in the reproductive organs of boars, especially in the post-SRF fraction. However, no relationship was observed between the enzyme and sperm quality/functionality parameters.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Martin Kratky, Peter Sramel, Pavol Bodo, Marta Soltesova Prnova, Lucia Kovacikova, Magdalena Majekova, Jarmila Vinsova, Milan Stefek
Summary: Aldose reductase, a key drug target in therapy of diabetic complications, can be inhibited by a series of six novel rhodanine based inhibitors. The compounds showed strong aldose reductase inhibitory activities with IC50 values ranging from 20 nM to 2000 nM. In silico docking revealed that the compounds interact with the anion-binding sub-pocket of aldose reductase through a deprotonated 4-hydroxyben-zylidene group, forming strong H-bond and charge interactions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Abdel-Rahim S. Ibrahim, Amany E. Ragab
Summary: Metabolites of fungus Cunninghamella echinulata NRRL 1382 were examined under the influence of fusidic acid (1) feeding. Apart from ergosterol (2) which is a fungal sterol, two new adipate esters (3, 4) were extracted and their structures were fully characterized using various spectroscopic techniques. In silico biological target prediction and molecular docking studies revealed that compound 3 could potentially act as an agonist/antagonist for the mu opioid receptor, while compound 4 exhibited aldose reductase inhibitory activity with potential antidiabetic effects.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Florence Souard, Sandrine Perrier, Vincent Noel, Claire Fave, Emmanuelle Fiore, Eric Peyrin, Julian Garcia, Cecile Vanhaverbeke
CHEMISTRY-A EUROPEAN JOURNAL
(2015)
Article
Ecology
Marie-Noelle Binet, Diederik van Tuinen, Florence Souard, Lucile Sage, Sophie Perigon, Christiane Gallet, Nicolas Legay, Sandra Lavorel, Bello Mouhamadou
Article
Biochemistry & Molecular Biology
Tsiry Rasamiravaka, Jeremie Ngezahayo, Laurent Pottier, Sofia Oliveira Ribeiro, Florence Souard, Leonard Hari, Caroline Stevigny, Mondher El Jaziri, Pierre Duez
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Chemistry, Applied
Florence Souard, Cedric Delporte, Piet Stoffelen, Etienne A. Thevenot, Nausicaa Noret, Bastien Dauvergne, Jean-Michel Kauffmann, Pierre Van Antwerpen, Caroline Stevigny
Article
Plant Sciences
Massimiliano Corso, M. Sol Schvartzman, Flavia Guzzo, Florence Souard, Eugeniusz Malkowski, Marc Hanikenne, Nathalie Verbruggen
Article
Chemistry, Analytical
Corenthin Mees, Florence Souard, Cedric Delporte, Eric Deconinck, Piet Stoffelen, Caroline Stevigny, Jean-Michel Kauffmann, Kris De Braekeleer
Article
Chemistry, Multidisciplinary
Ahcene Boumendjel, Germain Sotoing Taiwe, Elisabeth Ngo Bum, Tanguy Chabrol, Chantal Beney, Valerie Sinniger, Romain Haudecoeur, Laurence Marcourt, Soura Challal, Emerson Ferreira Queiroz, Florence Souard, Marc Le Borgne, Thierry Lomberget, Antoine Depaulis, Catherine Lavaud, Richard Robins, Jean-Luc Wolfender, Bruno Bonaz, Michel De Waard
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2013)
Article
Biochemistry & Molecular Biology
Florence Souard, Sabrina Okombi, Chantal Beney, Severine Chevalley, Alexis Valentin, Ahcene Boumendjel
BIOORGANIC & MEDICINAL CHEMISTRY
(2010)
Article
Chemistry, Organic
Vanessa Legros, Cecile Vanhaverbeke, Florence Souard, Christophe Len, Jerome Desire
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Mycology
Bello Mouhamadou, Mathieu Faure, Lucile Sage, Johanna Marcais, Florence Souard, Roberto A. Geremia
Article
Biochemistry & Molecular Biology
Islem Younes, Olfa Ghorbel-Bellaaj, Moncef Chaabouni, Marguerite Rinaudo, Florence Souard, Cecile Vanhaverbeke, Kernel Jellouli, Moncef Nasri
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2014)
Article
Biochemistry & Molecular Biology
Nguyen Thi Hoang Yen, Hany Ibrahim, Karine Reybier, Pierre Perio, Florence Souard, Ennaji Najahi, Paul-Louis Fabre, Francoise Nepveu
JOURNAL OF INORGANIC BIOCHEMISTRY
(2013)
Article
Chemistry, Organic
Mariam Traore, Marjorie Maynadier, Florence Souard, Luc Choisnard, Henri Vial, Yung-Sing Wong
JOURNAL OF ORGANIC CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Rocio Rodriguez-Gomez, Jerome Vanheuverzwjin, Florence Souard, Cedric Delporte, Caroline Stevigny, Piet Stoffelen, Kris De Braekeleer, Jean-Michel Kauffmann