Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain

The functions of TRPA1 and TRPV1: moving away from sensory nerves

(2012) ES Fernandes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach

(2012) Ralf Baron et al.   LANCET NEUROLOGY

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

(2012) Christian A. von Hehn et al.   NEURON

Contact heat and cold, mechanical, electrical and chemical stimuli to elicit small fiber-evoked potentials: Merits and limitations for basic science and clinical use

(2012) U. Baumgärtner et al.   NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY

A modified score to identify and discriminate neuropathic pain: a study on the German version of the neuropathic pain symptom inventory (NPSI)

(2011) Claudia Sommer et al.   BMC Neurology

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

(2011) P. Anand et al.   BRITISH JOURNAL OF ANAESTHESIA

Pain-associated Mild Sensory Deficits Without Hyperalgesia in Chronic Non-neuropathic Pain

(2011) Andrea Westermann et al.   CLINICAL JOURNAL OF PAIN

NGX-4010, a Capsaicin 8% Dermal Patch, Administered Alone or in Combination With Systemic Neuropathic Pain Medications, Reduces Pain in Patients With Postherpetic Neuralgia

(2011) Gordon A. Irving et al.   CLINICAL JOURNAL OF PAIN

Assessing symptom profiles in neuropathic pain clinical trials: Can it improve outcome?

(2011) Nadine Attall et al.   EUROPEAN JOURNAL OF PAIN

Nerve Growth Factor Modulates TRPV1 Expression and Function and Mediates Pain in Chronic Pancreatitis

(2011) Yaohui Zhu et al.   GASTROENTEROLOGY

Neurovascular Aspects of Skin Neurogenic Inflammation

(2011) Aisah A. Aubdool et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potentials

(2011) Michael Ragé et al.   JOURNAL OF NEUROLOGY

Genetic Evidence for an Essential Role of Neuronally Expressed IL-6 Signal Transducer gp130 in the Induction and Maintenance of Experimentally Induced Mechanical Hypersensitivity in vivo and in vitro

(2011) Serena Quarta et al.   Molecular Pain

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

(2011) Hsinlin T. Cheng et al.   NEUROBIOLOGY OF DISEASE

Increased cutaneous NGF and CGRP-labelled trkA-positive intra-epidermal nerve fibres in rat diabetic skin

(2011) Laura Evans et al.   NEUROSCIENCE LETTERS

TRP-channel-specific cutaneous eicosanoid release patterns

(2011) Anil Jain et al.   PAIN

Test–retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): A multi-centre study

(2011) Christian Geber et al.   PAIN

Double spikes to single electrical stimulation correlates to spontaneous activity of nociceptors in painful neuropathy patients

(2011) Roland Schmidt et al.   PAIN

Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients

(2011) Andreas Binder et al.   PLoS One

Sensory Symptom Profiles and Co-Morbidities in Painful Radiculopathy

(2011) Friederike Mahn et al.   PLoS One

Phenotypic Switching of Nonpeptidergic Cutaneous Sensory Neurons following Peripheral Nerve Injury

(2011) Ting Wang et al.   PLoS One

Capsaicin induces degeneration of cutaneous autonomic nerve fibers

(2010) Christopher H. Gibbons et al.   ANNALS OF NEUROLOGY

The time course of CO2 laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteers

(2010) Michael Ragé et al.   CLINICAL NEUROPHYSIOLOGY

EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

(2010) N. Attal et al.   EUROPEAN JOURNAL OF NEUROLOGY

Qutenza®: a capsaicin 8% patch for the management of postherpetic neuralgia

(2010) Mark Wallace et al.   Expert Review of Neurotherapeutics

TRPV1 splice variants: structure and function

(2010) Mark et al.   Frontiers in Bioscience-Landmark

A Comparative study of examination scores and quantitative sensory testing in diagnosis of diabetic polyneuropathy

(2010) A Mythili et al.   International Journal of Diabetes in Developing Countries

TRPV Channel Expression in Human Skin and Possible Role in Thermally Induced Cell Death

(2010) Christine Radtke et al.   Journal of Burn Care & Research

Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation

(2010) Sumiko Denda et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A Multicenter, Randomized, Double-Blind, Controlled Dose Finding Study of NGX-4010, a High-Concentration Capsaicin Patch, for the Treatment of Postherpetic Neuralgia

(2010) Lynn R. Webster et al.   JOURNAL OF PAIN

A Randomized, Controlled, Open-Label Study of the Long-Term Effects of NGX-4010, a High-Concentration Capsaicin Patch, on Epidermal Nerve Fiber Density and Sensory Function in Healthy Volunteers

(2010) William R. Kennedy et al.   JOURNAL OF PAIN

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

(2010) C. Maier et al.   PAIN

Natural history of cutaneous innervation following herpes zoster

(2010) Karin Lottrup Petersen et al.   PAIN

Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations

(2010) Robert H. Dworkin et al.   PAIN

Double and triple spikes in C-nociceptors in neuropathic pain states: An additional peripheral mechanism of hyperalgesia

(2010) Jordi Serra et al.   PAIN

NeuPSIG guidelines on neuropathic pain assessment

(2010) Maija Haanpää et al.   PAIN

NGX-4010, a High-Concentration Capsaicin Patch, for the Treatment of Postherpetic Neuralgia: A Randomized, Double-Blind, Controlled Study with an Open-Label Extension

(2010) Misha Miroslav Backonja et al.   PAIN MEDICINE

A Multicenter, Randomized, Double-Blind, Controlled Study of NGX-4010, a High-Concentration Capsaicin Patch, for the Treatment of Postherpetic Neuralgia

(2010) Gordon A. Irving et al.   PAIN MEDICINE

Inhibition and induction of human cytochrome P450 enzymesin vitroby capsaicin

(2010) Sunita Babbar et al.   XENOBIOTICA

Transient Receptor Potential Channels in Pain and Inflammation: Therapeutic Opportunities

(2010) Mark A. Schumacher   Pain Practice

Capsaicin receptor antagonists: a promising new addition to the pain clinic

(2009) D.G. Lambert   BRITISH JOURNAL OF ANAESTHESIA

Quantitative Sensory Testing in Measurement of Neuropathic Pain Phenomena and Other Sensory Abnormalities

(2009) Miroslav-Misha Backonja et al.   CLINICAL JOURNAL OF PAIN

TRP Channels and Pain

(2009) Daniel Cortright et al.   CURRENT PHARMACEUTICAL DESIGN

Putative neuronal mechanisms of sensitive skin

(2009) Sonja Ständer et al.   EXPERIMENTAL DERMATOLOGY

The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV1 in primary afferent neurons evoked by intradermal capsaicin

(2009) Xijin Xu et al.   EXPERIMENTAL NEUROLOGY

The Endoplasmic Reticulum of Dorsal Root Ganglion Neurons Contains Functional TRPV1 Channels

(2009) Sonia Gallego-Sandín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms

(2009) Ralf Baron et al.   PAIN

Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations

(2009) Robert H. Dworkin et al.   PAIN

Clinical effectiveness: An approach to clinical trial design more relevant to clinical practice, acknowledging the importance of individual differences

(2009) R. A. Moore et al.   PAIN

Pharmacokinetic Analysis of Capsaicin After Topical Administration of a High-Concentration Capsaicin Patch to Patients With Peripheral Neuropathic Pain

(2009) Sunita Babbar et al.   THERAPEUTIC DRUG MONITORING

Epidermal nerve fiber quantification in the assessment of diabetic neuropathy

(2008) Kristina K. Beiswenger et al.   ACTA HISTOCHEMICA

Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2

(2008) S. M. Huang et al.   JOURNAL OF NEUROSCIENCE

Sensitization of Primary Afferent Nociceptors Induced by Intradermal Capsaicin Involves the Peripheral Release of Calcitonin Gene-Related Peptide Driven by Dorsal Root Reflexes

(2008) Dingge Li et al.   JOURNAL OF PAIN

NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study

(2008) Miroslav Backonja et al.   LANCET NEUROLOGY

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy

(2008) D. M. Simpson et al.   NEUROLOGY

Mechanisms of potassium- and capsaicin-induced axonal calcitonin gene-related peptide release: Involvement of L- and T-type calcium channels and TRPV1 but not sodium channels

(2008) M.J.S. Spitzer et al.   NEUROSCIENCE

Human Keratinocytes Are Vanilloid Resistant

(2008) László Pecze et al.   PLoS One