Review
Medicine, General & Internal
Brian H. Buck, Naveed Akhtar, Anas Alrohimi, Khurshid Khan, Ashfaq Shuaib
Summary: Stroke mimics account for a significant proportion of hospital admissions, and accurate diagnosis with multi-modal CT or MRI is essential to avoid unnecessary treatment and costs. Prompt resolution of symptoms can be achieved in neurological and medical mimics, while treatment of functional disorders may be challenging and incomplete.
ANNALS OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Joseph Benzakoun, Sylvain Charron, Guillaume Turc, Wagih Ben Hassen, Laurence Legrand, Gregoire Boulouis, Olivier Naggara, Jean-Claude Baron, Bertrand Thirion, Catherine Oppenheim
Summary: Machine Learning has been utilized for tissue fate prediction after acute ischemic stroke, with Gradient Boosting model showing superior predictive performance compared to other ML models and clinical methods. This suggests promising potential for future decision-making in stroke management.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Camilla Sammut-Powell, Christopher Ashton, Kyriaki Paroutoglou, Adrian Parry-Jones
Summary: A study conducted in Greater Manchester found that many suspected stroke patients in the prehospital setting were actually diagnosed with stroke mimics rather than strokes. Some patients had pathway exclusions, with a lower proportion of them being diagnosed with stroke in the end.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rehabilitation
Leonardo Pellicciari, Maurizio Agosti, Michela Goffredo, Sanaz Pournajaf, Domenica Le Pera, Francesco De Pisi, Marco Franceschini, Carlo Damiani
Summary: Functional outcome is the primary objective of rehabilitation programs, and factors such as initial mBI score, age, disease type, and presence of impairments and complications can significantly influence the functional outcome at discharge. It is important to consider these prognostic factors when planning personalized rehabilitation programs.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Medicine, General & Internal
Vincenzo Livio Malavasi, Anna Chiara Valenti, Sara Ruggerini, Marcella Manicardi, Carlotta Orlandi, Daria Sgreccia, Marco Vitolo, Marco Proietti, Gregory Y. H. Lip, Giuseppe Boriani
Summary: This study aimed to evaluate the concordance between the CKD-EPI formula and alternative equations in predicting all-cause mortality in cardiology ward patients. The study found that the concordance between the CKD-EPI formula and other equations decreased with age, and the MDRD formula showed the best agreement in both younger and older patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Vivienne Huppertz, Sonia Guida, Anne Holdoway, Stefan Strilciuc, Laura Baijens, Jos M. G. A. Schols, Ardy van Helvoort, Mirian Lansink, Dafin F. Muresanu
Summary: This systematic review examines the prevalence of impaired nutritional condition (INC) across different phases after stroke. The study finds that INC and malnutrition are highly prevalent in all stages of stroke care. Since malnutrition has been shown to negatively affect clinical outcomes, mortality, and overall healthcare expenditure in stroke survivors, it is essential to examine and monitor the nutritional status of stroke patients throughout their care journey to guide and plan timely nutritional support and dietary modification.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Mathias Barra, Kashif Waqar Faiz, Fredrik Andreas Dahl, Halvor Naess
Summary: The study found that the proportion of stroke mimics (SM) in a general hospital's stroke unit has been increasing, with approximately half of SU admissions being SM. Additionally, the study showed that the age- and sex-dependent incidence of SM is increasing but appears to be flattening out over time.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Huan Cai, Hao Zhang, Jialin Liang, Zhonghua Liu, Guozhi Huang
Summary: Using the Mendelian randomization (MR) framework, this study found evidence of a possible causal effect of frailty on poor functional outcome after ischemic stroke. The findings highlight the potential of targeting frailty as an intervention to improve recovery after ischemic stroke.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Medicine, General & Internal
Lotte E. Terwindt, Jaap Schuurmans, Bjorn J. P. van der Ster, Carin A. G. C. L. Wensing, Marijn P. Mulder, Marije Wijnberge, Thomas G. Cherpanath, Wim K. Lagrand, Alain A. Karlas, Mark H. Verlinde, Markus W. Hollmann, Bart F. Geerts, Denise P. Veelo, Alexander P. J. Vlaar
Summary: This study observed the incidence and severity of hypotension in ICU patients and found that the incidence of hypotension is remarkably high with a certain level of severity. Age, sex, BMI, and cardiogenic shock are associated clinical factors for hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rehabilitation
Vincent T. Carpentier, Marjorie Salga, Laure Gatin, Francois Genet, Julie Paquereau
Summary: This study investigated the prevalence of HO and the time of diagnosis among patients admitted to a neurological PICRU. The results showed that 24 out of 125 patients were diagnosed with HO, with 75% of cases being diagnosed in PICRU and typically within the first week after admission.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Clinical Neurology
Fouzi Bala, Manon Kappelhof, Johanna M. Ospel, Petra Cimflova, Wu Qiu, Nishita Singh, Kairan Zhu, Beom Joon Kim, Ankur Wadhwa, Mohammed A. Almekhlafi, Bijoy K. Menon, Nerea Arrarte Terreros, Henk Marquering, Charles Majoie, Michael D. Hill, Mayank Goyal
Summary: This study investigated the association between radiological thrombus characteristics and treatment details with distal embolization (DE) in endovascular treatment (EVT). The factors associated with DE were thrombus length, balloon guide catheter use, and number of passes. Intravenous thrombolysis (IVT) was found to reduce the risk of DE in patients with hyperdense artery sign.
Article
Clinical Neurology
Andreia Matas, Luisa Amaral, Assuncao Vaz Patto
Summary: The study examined the association between insomnia and cognitive as well as functional outcomes in ischemic stroke patients, finding that insomnia may negatively influence neurological recovery and be associated with worse functional and cognitive outcomes in these patients.
Article
Geriatrics & Gerontology
Wolfram Doehner, Nadja Scherbakov, Tim Schellenberg, Ewa A. Jankowska, Jan F. Scheitz, Stephan Haehling, Michael Joebges
Summary: This study found that iron deficiency and anemia are common and persistent findings in patients after acute stroke. Iron deficiency and anemia are independently related to lower functional capacity after acute stroke and to poor functional outcome after rehabilitation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Clinical Neurology
Peter B. Sporns, Thilo Rusche, Sarah Lee, Uta Hanning, Lukas Meyer, Tobias Faizy, Jens Fiehler, Marios Psychogios, Andre Kemmling, Gabriel Broocks
Summary: This study found that children may have higher edema formation measured by net water uptake (NWU) compared to adults, but despite this, children had better functional outcomes. The results suggest that the degree of early ischemic changes and edema progression rate may not be a reason to exclude children from endovascular thrombectomy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Han Eum Choi, Jae Hyun Lee, Young-Joo Sim, Ho Joong Jeong, Ghi Chan Kim
Summary: The study investigated factors affecting the duration of VRE colonization in stroke patients. It found that oral feeding, use of antibiotics, and duration of ICU care were independent factors influencing the duration of VRE colonization. Attention should be given to these factors, especially in hemorrhagic stroke patients, for intensive rehabilitation at the appropriate time.
Article
Clinical Neurology
Graham Blackman, Kieron Kumar, John G. Hanrahan, Anthony Dalrymple, Nandini Mullatti, Nick Moran, Antonio Valentin, Lucy Gibson, Thomas A. Pollak, Anthony S. David
Summary: In this study, the authors explored whether quantitative EEG could predict outcomes in patients with suspected anti-NMDAR encephalitis. The results showed that patients with higher peak frequency in the delta range had poorer clinical outcomes, indicating anti-NMDAR-mediated synaptic dysfunction. Quantitative EEG may have clinical utility in predicting outcomes in patients with suspected NMDAR antibody encephalitis, but replication in a larger scale is needed.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Psychology, Clinical
Jonathan P. Rogers, Thomas A. Pollak, Nazifa Begum, Anna Griffin, Ben Carter, Megan Pritchard, Matthew Broadbent, Anna Kolliakou, Jessie Ke, Robert Stewart, Rashmi Patel, Adrian Bomford, Ali Amad, Michael S. Zandi, Glyn Lewis, Timothy R. Nicholson, Anthony S. David
Summary: Catatonia occurred in approximately 1 per 10,000 person-years in this study. Patients with catatonia had longer duration of hospitalisation, but there was no increase in mortality after adjustment.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Clinical
Jinyan Yang, L. S. Merritt Millman, Anthony S. David, Elaine C. M. Hunter
Summary: Depersonalization-Derealization disorder has a prevalence rate of around 1% in the general population and is more prevalent among individuals with mental disorders. There may be a relationship between interpersonal abuse and Depersonalization-Derealization disorder.
JOURNAL OF TRAUMA & DISSOCIATION
(2023)
Review
Medicine, General & Internal
Paris Hosseini, Rebecca Whincup, Karrish Devan, Dory Anthony Ghanem, Jack B. Fanshawe, Aman Saini, Benjamin Cross, Apoorva Vijay, Tomas Mastellari, Umesh Vivekananda, Steven White, Franz Brunnhuber, Michael S. Zandi, Anthony S. David, Ben Carter, Dominic Oliver, Glyn Lewis, Charles Fry, Puja R. Mehta, Biba Stanton, Jonathan P. Rogers
Summary: This study aimed to determine the performance of EEG in determining whether catatonia has a medical or psychiatric cause. The study found that an abnormal EEG predicted a medical cause of catatonia with fair accuracy, but performed poorly in distinguishing psychiatric causes.
Article
Medicine, General & Internal
Jonathan P. Rogers, Michael S. Zandi, Anthony S. David
Summary: Catatonia is a severe syndrome that affects various aspects of human functioning and can be caused by different psychiatric and neurological conditions. The main treatment options are benzodiazepines and/or electroconvulsive therapy, while important investigations may include neuroimaging and assessment for neuronal autoantibodies. However, the guidelines are limited by the lack of high-quality evidence.
Article
Medicine, General & Internal
Cheng Zhang, Shanshan Wei, Yunxia Wang, Kunyao Yu, Zhe Jin, Meng Zhang, Xiaoyu Ma, Chunbo Zhang, Qi Zhang, Kunyan Sun, Peining Zhou, Yijue Zhong, Jing Ma, Jiping Liao, Guangfa Wang
Summary: This study investigated the association between obstructive sleep apnea (OSA) and preserved ratio impaired spirometry (PRISm) in a community population. The findings showed that the prevalence of high-risk OSA, waist-to-hip ratio, current smoking, and nasal allergy symptoms were independently associated with PRISm.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Editorial Material
Psychology, Clinical
S. Siddi, R. Bailon, I. Gine-Vazquez, F. Matcham, F. Lamers, S. Kontaxis, E. Laporta, E. Garcia, F. Lombardini, P. Annas, M. Hotopf, B. W. J. H. Penninx, A. Ivan, K. M. White, S. Difrancesco, P. Locatelli, J. Aguilo, M. T. Penarrubia-Maria, V. A. Narayan, A. Folarin, D. Leightley, N. Cummins, S. Vairavan, Y. Ranjan, A. Rintala, G. de Girolamo, S. K. Simblett, T. Wykes, I. Myin-Germeys, R. Dobson, J. M. Haro
Summary: This 2-year study examined the intra-individual variations in heart rate (HR) parameters and their relationship with depression severity in individuals with recurrent major depressive disorder. The results showed that decreased HR variation during resting periods during the day was associated with increased depression severity, and higher mean HR during resting at night was observed in participants with more severe depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Chengyu Zhang, Suzanne Reeves, Anthony S. David, Harry Costello, Jonathan Rogers
Summary: Psychotic symptoms such as hallucinations and delusions were rare in hospitalized Parkinson's disease patients prior to the use of dopaminergic therapies, but other neuropsychiatric symptoms were more prevalent.
COGNITIVE NEUROPSYCHIATRY
(2023)
Article
Psychology, Experimental
Andrew McWilliams, Hannah Bibby, Nikolaus Steinbeis, Anthony S. David, Stephen M. Fleming
Summary: Metacognition refers to the ability to reflect on and control cognitive processes, and conflicting evidence exists regarding how local and global metacognition change across the lifespan. The study measured local and global metacognition in a sample of 304 healthy volunteers aged 18-83 years. The results showed that overall confidence in performance decreased with age, but local metacognitive efficiency remained stable and correlated across cognitive domains.
Article
Substance Abuse
George Konstantakopoulos, Anna Trova, Elias Tzavellas, Pentagiotissa Stefanatou, Anthony S. David, Thomas Paparrigopoulos
Summary: The study aimed to develop a clinician-rated scale to assess impaired insight in patients with alcohol use disorder and examine its reliability and validity. The Schedule for the Assessment of Insight in Alcohol Dependence (SAI-AD) showed good convergent validity and internal consistency. Three subscales were identified, measuring different components of insight.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Clinical Neurology
Nicholas Cummins, Judith Dineley, Pauline Conde, Faith Matcham, Sara Siddi, Femke Lamers, Ewan Carr, Grace Lavelle, Daniel Leightley, Katie M. White, Carolin Oetzmann, Edward L. Campbell, Sara Simblett, Stuart Bruce, Josep Maria Haro, Brenda W. J. H. Penninx, Yatharth Ranjan, Zulqarnain Rashid, Callum Stewart, Amos A. Folarin, Raquel Bailon, Bjoern W. Schuller, Til Wykes, Srinivasan Vairavan, Richard J. B. Dobson, Vaibhav A. Narayan, RADAR-CNS Consortium
Summary: Speech rate, articulation rate, and intensity of speech are associated with depressive symptoms, suggesting that these speech features may serve as biomarkers for major depressive disorder (MDD). This study collected real-world data, providing significant insights into the onset and progress of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Jonathan P. Rogers, Michael K. L. Chou, Thomas A. Pollak, Michael Eyre, Maria Krutikov, Andrew Church, Melanie S. Hart, Abid Karim, Sophia Michael, Angela Vincent, Anthony S. David, Glyn Lewis, Saiju Jacob, Michael S. Zandi
JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Clinical
Simone Farrelly, Emmanuelle Peters, Matilda Azis, Anthony S. David, Elaine C. M. Hunter
Summary: This study aimed to investigate the feasibility and acceptability of a six-session therapy protocol adapted from a Cognitive-Behavioural model of Depersonalisation-Derealisation Disorder (DDD) in individuals with psychotic symptoms. The results suggest that the intervention was feasible and acceptable to participants, with some indication of its effectiveness on clinical outcomes.
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY
(2024)
Article
Behavioral Sciences
Elaine C. M. Hunter, Cheuk Lon Malcolm Wong, Rafael Gafoor, Glyn Lewis, Anthony S. David
Summary: This article reports on a clinical audit of 36 participants with chronic DDD who completed Cognitive Behavioural Therapy adapted for DDD. The results showed improvement in all scores during the treatment period, suggesting that CBT may be an effective treatment for DDD. However, more research is needed to assess its efficacy.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Article
Psychiatry
Javier-David Lopez-Morinigo, Adela Sanchez-Escribano Martinez, Maria Luisa Barrigon, Paula-Jhoana Escobedo-Aedo, Veronica Gonzalez Ruiz-Ruano, Sergio Sanchez-Alonso, Laura Mata-Iturralde, Laura Munoz-Lorenzo, Daniel Cuadras, Susana Ochoa, Enrique Baca-Garcia, Anthony S. David
Summary: This study aimed to test whether metacognitive training (MCT) can improve insight and outcomes in outpatients with schizophrenia spectrum disorders (SSD). The results showed that participants receiving MCT showed improvements in cognition, mood, and identification at the 1-year follow-up.