Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Abeer Abdulaziz H. Bukhari
Summary: Three biodegradable wound dressings were successfully prepared using freeze drying technique. The dressings were based on binary Collagen (COL), Hyaluronic acid (HA) crosslinked and loaded with silver nanoparticles (AgNPs), Gentamicin (GENT), or AgNPs/GENT. The dressings showed physically interaction between polymer network and the loaded antibiotic, superior swelling properties, and rapid degradation. They exhibited antibacterial activity against G+, G-, yeast, and fungi. Cytotoxicity and wound healing evaluations showed superior results for all dressings except the one mixed with AgNPs and Gentamicin. The results recommended individually loaded COL/HA with either AgNPs or Gentamicin as antibacterial and wound healing dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Kummara Madhusudana Rao, Eunbi Kim, Hyeon Jin Kim, Uluvangada Thammaiah Uthappa, Sung Soo Han
Summary: A water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate was synthesized and evaluated for its potential wound-healing properties. The conjugation was confirmed using FTIR, UV-Vis, and NMR spectroscopy techniques. HA-Q showed good biocompatibility, supported cell growth and migration, and exhibited improved radical scavenging capacity compared to quercetin alone. These results confirm the potential role of HA-Q in wound healing applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Min Wang, Juanjuan Hu, Yangcen Ou, Xueling He, Yanjun Wang, Chenyu Zou, Yanlin Jiang, Feng Luo, Dan Lu, Zhen Li, Jiehua Li, Hong Tan
Summary: There is an urgent need for wound dressings that can promote quick hemostasis and efficient wound healing in response to increasing clinical demands. This study presents a versatile method for constructing biodegradable hybrid cryogels that can rapidly stop bleeding. The cryogel's specific macroporous structure allows for stable fixation and quick swelling, making it ideal for minimally invasive surgery. Furthermore, the cryogel exhibits excellent biocompatibility and activates the endogenous coagulation system, leading to fast blood coagulation. In in vivo evaluations, the cryogel demonstrated great potential in promoting wound healing, reducing immune inflammation, and inducing angiogenesis and hair follicle regeneration. These findings highlight the high-performance capabilities of the cryogel as a wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Dermatology
Klaus Kirketerp-Moller, Petra Doerfler, Nicole Schoefmann, Barbara Wolf-Winiski, Omid Niazi, Vibeke Pless, Tonny Karlsmark, Magnus Agren
Summary: This exploratory study aimed to investigate the association between biomarkers in wound fluid and the healing of split-thickness skin grafts in venous leg ulcers. The study found that the concentration of matrix metalloproteinase-9 in wound fluid was higher in venous leg ulcers showing good healing compared to those with poor healing.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Engineering, Multidisciplinary
Qiusheng Wang, Shuiqing Zhou, Lu Wang, Renchuan You, Shuqin Yan, Qiang Zhang, Mingzhong Li
Summary: This study presents a novel bioactive scaffold designed with biomimetic technology by mimicking the chemical components and biophysical nanostructures of extracellular matrix. The scaffold showed better cytocompatibility to support cell spread, proliferation and differentiation. In vivo experiments demonstrated that the scaffold with nanofibers as a template not only accelerated wound healing but also regulated collagen arrangement to inhibit scar formation.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Carolini Mendes, Anand Thirupathi, Rubya Pereira Zaccaron, Maria Eduarda Anastacio Borges Correa, Joao V. S. Bittencourt, Laura de Roch Casagrande, Anadhelly C. S. de Lima, Lara L. de Oliveira, Thiago A. M. de Andrade, Yaodong Gu, Paulo Emilio Feuser, Ricardo A. Machado-de-Avila, Paulo Cesar Lock Silveira
Summary: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. The results demonstrate that the combination therapy group showed better results in anti-inflammation and tissue repair process compared to the single therapy group.
Article
Engineering, Biomedical
Yihao Liu, Haoyi Niu, Chengwei Wang, Xiaoxiao Yang, Wentao Li, Yuxin Zhang, Xiaojun Ma, Yuanjing Xu, Pengfei Zheng, Jinwu Wang, Kerong Dai
Summary: This study developed a new hydrogel material with biocompatibility, easy degradation, and wound healing properties using physical electrostatic cross-linking and freeze-drying. The material showed excellent antibacterial and pro-coagulation abilities, promoting hemostasis and reducing blood loss in both in vitro and in vivo experiments. Additionally, it exhibited superior cytocompatibility and biodegradability. Therefore, this material has great potential for clinical application as a hemostatic and wound healing material.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Zijian Wang, Wenjie You, Wang Wang, Weiqun Tian, Fangjin Chen, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This study successfully improved wound healing effects through a novel nanofiber material, which exhibited multifunctional properties and showed promising results in experimental animal models.
ADVANCED FIBER MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Ebrahim Astaneh, Narges Fereydouni
Summary: Diabetic wounds pose a significant clinical challenge due to impaired healing and increased risk of complications. Nanofiber-based wound dressings, particularly those containing hyaluronic acid, show promise in promoting wound healing by enhancing skin hydration, controlling inflammation, and facilitating revascularization. However, challenges and limitations, such as reproducibility and proper characterization, exist in the field of nanofiber technology. Future directions involve addressing these issues and optimizing nanofiber formulations for improved efficacy in diabetic wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Marcel Nani Leite, Marco Andrey Cipriani Frade
Summary: This study evaluated the efficacy of 0.2% hyaluronic acid in enhancing the healing of skin abrasions in rats, showing that the hyaluronic acid group had better re-epithelialization and thinner crust compared to other groups. There were also differences in myeloperoxidase enzyme levels among the groups.
Article
Pharmacology & Pharmacy
Lisa Marinelli, Ivana Cacciatore, Erica Costantini, Marilisa Pia Dimmito, Federica Serra, Antonio Di Stefano, Marcella Reale
Summary: In this study, the application of water-soluble carvacrol prodrugs (WSCPs) and hyaluronic acid (HA) was investigated to improve wound healing and regulate the inflammatory response. The results showed that WSCPs/HA formulations significantly increased the wound closure rate and modulated the expression of reparative and inflammatory mediators.
Article
Dentistry, Oral Surgery & Medicine
Jeong Hyun Lee, Ko Eun Lee, Sang Wook Kang, Seung Hwan Park, Yong Kwon Chae, Myoung-Han Lee, Dong-Keun Kweon, Sung Chul Choi, Ok Hyung Nam
Summary: The objective of this study was to evaluate the healing effect of hyaluronic acid films on palatal wounds. The results showed that hyaluronic acid films outperformed gels in terms of palatal wound healing in both rat and human models. Therefore, hyaluronic acid films have potential for the treatment of palatal wounds.
Review
Dermatology
Jasmin Bossert, Johannes A. Vey, Lars Piskorski, Thomas Fleischhauer, Sinclair Awounvo, Joachim Szecsenyi, Jonas Senft
Summary: Educational interventions for venous leg ulceration (VLU) patients may promote adherence and self-management, and have a positive impact on wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Yihua Wang, Yanxia Shi, Jie Liu, Wenzhi Yang, Hongbo Tang, Haiying Li
Summary: A novel cross-linked film dressing (HA-Pro-Fe3+) with good properties like antibacterial ability, biocompatibility, and promotion of cell proliferation and angiogenesis, was successfully prepared in this study. The results of rat skin wound healing showed that the HA-Pro-Fe3+ film could accelerate epithelial regeneration, collagen deposition, and angiogenesis, significantly improving wound healing. Elisa analysis indicated that the HA-Pro-Fe3+ material could down-regulate the expression of IL-6 and TNF-α, and up-regulate the level of TGF-β1 and VEGF.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Mohamed R. El-Aassar, Nagham G. El-Beheri, Mona M. Agwa, Hoda M. Eltaher, Mostafa Alseqely, Wagih S. Sadik, Labiba El-Khordagui
Summary: The study innovatively functionalized nanofibers with a combination of new ZnO NPs and cinnamon essential oil, showing great potential for wound healing. The combinational approach of metal NPs/essential oil functionalization of nanofibers is promising as an emerging antibiotic-free method for effective and safer wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Ceren Sunguc, Michael M. Hawkins, David L. Winter, Isabelle M. Dudley, Emma J. Heymer, Jop C. Teepen, Rodrigue S. Allodji, Fabien N. Belle, Francesca Bagnasco, Julianne Byrne, Edit Bardi, Cecile M. Ronckers, Nadia Haddy, Thorgerdur Gudmundsdottir, Stanislaw Garwicz, Momcilo Jankovic, Helena J. H. van der Pal, Maja Cesen Mazic, Christina Schindera, Desiree Grabow, Milena M. Maule, Peter Kaatsch, Melanie Kaiser, Brice Fresneau, Gisela Michel, Roderick Skinner, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Jeanette F. Winther, Paivi M. Lahteenmaki, Lorna Zadravec Zaletel, Claudia E. Kuehni, Leontien C. Kremer, Riccardo Haupt, Florent de Vathaire, Lars Hjorth, Raoul C. Reulen
Summary: Childhood cancer survivors are at higher risk of developing salivary gland and tongue cancers, particularly those who have received radiotherapy or chemotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Thi-Van-Trinh Tran, Cari Meinhold Kitahara, Laurence Leenhardt, Florent de Vathaire, Marie-Christine Boutron-Ruault, Neige Journy
Summary: In this updated meta-analysis, an association between hyperthyroidism and increased breast cancer risk, as well as no association between hypothyroidism and breast cancer risk, was found. Menopausal status and blood levels of thyroid-stimulating hormone (TSH) and thyroid hormones were found to modify this association.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Esmee C. de Baat, Elizabeth A. M. Feijen, Raoul C. Reulen, Rodrigue S. Allodji, Francesca Bagnasco, Edit Bardi, Fabien N. Belle, Julianne Byrne, Elvira C. van Dalen, Ghazi Debiche, Ibrahima Diallo, Desiree Grabow, Lars Hjorth, Momcilo Jankovic, Claudia E. Kuehni, Gill Levitt, Damien Llanas, Jacqueline Loonen, Lorna Z. Zaletel, Milena M. Maule, Lucia Miligi, Helena J. H. van der Pal, Cecile M. Ronckers, Carlotta Sacerdote, Roderick Skinner, Zsuzsanna Jakab, Cristina Veres, Nadia Haddy, David L. Winter, Florent de Vathaire, Michael M. Hawkins, Leontien C. M. Kremer
Summary: This study evaluated the risk and risk factors for heart failure in childhood cancer survivors and highlighted the impact of radiation therapy and anthracycline dose on the risk. These findings may have important implications for improving current treatment protocols and surveillance guidelines.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Isabelle M. Dudley, Ceren Sunguc, Emma J. Heymer, David L. Winter, Jop C. Teepen, Fabien N. Belle, Edit Bardi, Francesca Bagnasco, Thorgerdur Gudmundsdottir, Roderick Skinner, Gisela Michel, Julianne Byrne, Hilde Ofstaas, Momcilo Jankovic, Maja Cesen Mazic, Luzius Mader, Jaqueline Loonen, Stanislaw Garwicz, Thomas Wiebe, Daniela Alessi, Rodrigue S. Allodji, Nadia Haddy, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Milena M. Maule, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Lorna Zadravec Zaletel, Claudia E. Kuehni, Riccardo Haupt, Florent de Vathaire, Leontien C. Kremer, Paivi M. Lahteenmaki, Jeanette F. Winther, Lars Hjorth, Michael M. Hawkins, Raoul C. Reulen
Summary: This study found that survivors of Hodgkin lymphoma (HL) are at an increased risk of developing non-Hodgkin lymphoma (NHL) after treatment. The researchers also identified other types of childhood cancer survivors who are at risk of developing NHL, including survivors of Wilms tumor, leukemia, and bone sarcoma. Treatment with chemotherapy increased the risk of NHL, while treatment with radiotherapy did not.
Article
Oncology
Imene Mansouri, Boris Schwartz, Giao Vu-Bezin, Daniel Bejarano-Quisoboni, Brice Fresneau, Chiraz El-Fayech, Christelle Dufour, Stephanie Bolle, Aurore Surun, Daniel Orbach, Rodrigue S. Allodji, Ibrahima Diallo, Charlotte Demoor-Goldschmidt, Florent de Vathaire, Nadia Haddy
Summary: This study aimed to determine the long-term risks of hospitalization related to renal and urinary diseases among 5-year childhood cancer survivors (CCS). The results showed that CCS had a higher risk of renal hospitalization compared to the general population, and radiation therapy with certain dose-volume indicators increased the risk. It also identified specific risk factors associated with hospitalization for renal causes among CCS.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Thomas Sarrade, Rodrigue Allodji, Youssef Ghannam, Guillaume Auzac, Sibille Everhard, Youlia Kirova, Karine Peignaux, Philippe Guilbert, David Pasquier, Severine Racadot, Celine Bourgier, Sandrine Ducornet, Fabrice Andre, Florent De Vathaire, Sofia Rivera
Summary: The manuscript describes the methodology and the characterization of the study population and radiation therapy (RT) data in CANTO-RT (Cancer Toxicities RadioTherapy). This study is the largest available multicenter cohort of early breast cancer with full DICOM RT data, aiming to identify predictors of long-term toxicities in breast cancer patients.
Article
Oncology
Raoul C. Reulen, David L. Winter, Ibrahim Diallo, Cristina Veres, Damien Llanas, Rodrigue S. Allodji, Francesca Bagnasco, Edit Bardi, Elizabeth A. M. Feijen, Daniela Alessi, Miranda M. Fidler-Benaoudia, Stine Hogsholt, Jop C. Teepen, Helena Linge, Nadia Haddy, Julianne Byrne, Ghazi Debiche, Desiree Grabow, Thorgerdur Gudmundsdottir, Romain Fauchery, Wael Zrafi, Gisela Michel, Hilde ofstaas, Peter Kaatsch, Giao Vu-Bezin, Helen Jenkinson, Melanie Kaiser, Roderick Skinner, Trevor Cole, Nicolas Waespe, Grit Sommer, Susanne Nordenfelt, Momcilo Jankovic, Tuomas Lahteenmaki Taalas, Milena M. Maule, Helena J. H. van der Pal, Cecile M. Ronckers, Flora E. van Leeuwen, Judith L. Kok, Monica Terenziani, Maria Winther Gunnes, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Riccardo Haupt, Paivi M. Lahteenmaki, Lorna Zadravec Zaletel, Claudia E. Kuehni, Jeanette Falck Winther, Leontien C. M. Kremer, Lars Hjorth, Florent de Vathaire, Michael M. Hawkins
Summary: Radiation and exposure to alkylating agents increase the risk of bone cancer among survivors of childhood cancer. This study demonstrates, for the first time, that the risk of bone cancer is increased 5-10 fold after exposure of bone tissue to cumulative radiation doses of 1-9 Gy. Alkylating agents exceeding 10,000 mg/m(2), particularly procarbazine, ifosfamide, and cyclophosphamide, increase the risk 7-8 fold. These findings should be used to develop/update clinical follow-up guidelines and survivorship care plans.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Pierre-Emmanuel Sugier, Elise A. Lucotte, Cloe Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq-Daian, Anne Boland-Auge, Robert Olaso, Jean-francois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guenel, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Roedstroem, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Therese Truong, Alexis Elbaz
Summary: By using genome-wide association studies, this study found that Parkinson's disease (PD) is genetically correlated with melanoma and prostate cancer, while it is inversely correlated with ovarian cancer. These findings suggest that pleiotropic genes contribute to the association between PD and specific cancers.
MOVEMENT DISORDERS
(2023)
Article
Endocrinology & Metabolism
Laurene Delacourt, Rodrigue Allodji, Juliette Chappat, Nadia Haddy, Chiraz El-Fayech, Charlotte Demoor-Goldschmidt, Neige Journy, Stephanie Bolle, Cecile Thomas-Teinturier, Monia Zidane, Carole Rubino, Cristina Veres, Giao Vu-Bezin, Delphine Berchery, Claire Pluchart, Pierre-Yves Bondiau, Agnes Dumas, Nicolas Bougas, Jacques Grill, Christelle Dufour, Brice Fresneau, Helene Pacquement, Ibrahima Diallo, Francois Doz, Florent de Vathaire
Summary: This study aimed to identify risk factors for obesity in childhood cancer survivors (CCSs). The study found that CCSs had a lower risk of obesity compared to the general French population. However, brain tumor survivors had a significantly higher risk of developing obesity. Patients who received radiotherapy to the pituitary gland and those who received etoposide treatment also had an increased risk of obesity.
Article
Medicine, General & Internal
Florent de Vathaire, Monia Zidane, Constance Xhaard, Vincent Souchard, Sylvie Chevillard, Catherine Ory, Frederique Rachedi, Sebastien Nunez, Axelle Leufroy, Laurent Noel, Thierry Guerin, Larys Shan, Frederique Bost-Bezeaud, Patrice Petitdier, Gilles Soubiran, Rodrigue Allodji, Yan Ren, Francoise Doyon, Marc Taquet, Jacques Gardon, Andre Bouville, Vladimir Drozdovitch
Summary: This study examines the association between radiation exposure from French nuclear tests and the risk of thyroid cancer. The results suggest that there is an increase in the risk of thyroid cancer, although the credibility of the findings is reduced due to inconsistencies with the initial study. The lifetime risk of thyroid cancer in the population of French Polynesia is estimated to be 2.3%.
Article
Economics
Daniel Bejarano-Quisoboni, Henri Panjo, Brice Fresneau, Chiraz El-Fayech, Francois Doz, Aurore Surun, Florent de Vathaire, Nathalie Pelletier-Fleury
Summary: This study aimed to estimate the excess healthcare expenditure for long-term childhood cancer survivors (CCS) in France compared to the general population and investigate the associated factors. The study found that CCS had higher healthcare expenditure, mainly due to hospitalization and pharmacy expenses. The type of treatment administered was a key factor influencing healthcare expenditure.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Medicine, Research & Experimental
Monia Zidane, Marc Haber, Therese Truong, Frederique Rachedi, Catherine Ory, Sylvie Chevillard, Helene Blanche, Robert Olaso, Anne Boland, Eric Conte, Mojgan Karimi, Yan Ren, Constance Xhaard, Vincent Souchard, Jacques Gardon, Marc Taquet, Andre Bouville, Jean-Francois Deleuze, Vladimir Drozdovitch, Florent de Vathaire, Jean-Baptiste Cazier
Summary: This study aimed to analyze the genetic factors associated with differentiated thyroid cancer (DTC) risk among the native populations of French Polynesia (FP). The research identified three genetic loci associated with increased DTC risk and suggested the need for whole genome sequencing to characterize these factors and validate their functional impact.
PRECISION CLINICAL MEDICINE
(2023)
Article
Oncology
Agnes Dumas, Karen Milcent, Nicolas Bougas, Daniel Bejarano-Quisoboni, Chiraz El Fayech, Helene Charreire, Odile Oberlin, Catherine Patte, Julie Allard, Eric Thebault, Amel Boumaraf, Amel Belhout, Vu-Bezin Giao, Vincent Souchard, Angela Jackson, Rodrigue Allodji, Dominique Valteau-Couanet, Christelle Dufour, Gilles Vassal, Nadia Haddy, Florent De Vathaire, Brice Fresneau
Summary: The study found that patients who received combined chemotherapy and radiotherapy, had bone sarcoma, central nervous system primitive tumor, or underwent autologous hematopoietic cell transplant were more likely to attend long-term follow-up visits. Additionally, factors such as health status, medical expenses, social status, and distance from the follow-up center also influenced attendance.
Article
Cardiac & Cardiovascular Systems
Manoj Kumar Honaryar, Rodrigue Allodji, Gaelle Jimenez, Mathieu Lapeyre, Loic Panh, Jeremy Camilleri, David Broggio, Jean Ferrieres, Florent De Vathaire, Sophie Jacob
Summary: This study aimed to evaluate the development of atherosclerotic plaques over 2 years after breast cancer radiotherapy (RT) and their associations with cardiac exposure. The results showed that the risk of overall plaque development was significantly associated with doses to the coronary arteries.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Dermatology
Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini
Summary: This study aimed to assess the correlation between serum amyloid A (SAA) levels and various factors in Hidradenitis suppurativa (HS) patients. The results showed that SAA levels were associated with number of nodules, abscesses, fistulas, and severe IHS4. Gluteal localization was also correlated with high values of mSartorius and severe IHS4. Therefore, monitoring SAA levels in HS patients is recommended to prevent disease flare-ups and potential complications.
SKIN APPENDAGE DISORDERS
(2023)