Journal
CURRENT HYPERTENSION REPORTS
Volume 20, Issue 10, Pages -Publisher
SPRINGER
DOI: 10.1007/s11906-018-0891-x
Keywords
Pre-eclampsia; Candidate gene studies; Genome-wide association studies; Bioinformatic studies; Apol-1 gene polymorphisms
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Purpose of Review Regardless of the familial linkage reported in pre-eclampsia development, understanding the polymorphic genes associated with pre-eclampsia remains limited. Hence, this review aims to outline the main genetic factors that have been investigated in respect to pre-eclampsia development. Recent Findings It is apparent that different genes show significance in varying populations. Notably, it is reported that apolipoprotein-1 gene polymorphisms are associated with pre-eclampsia development in an African-American population, which may be worthwhile to investigate in a Black South African cohort. Summary Despite the research attention that is focused on this surreptitious syndrome, a definitive cause eludes scientists and physicians, alike. Genetic studies can fulfil a dual purpose of suggesting novel hypotheses through genome-wide screening and testing these hypotheses via candidate gene studies. However, publications to date have only presented inconsistent and conflicting results regarding candidate gene analysis.
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