Article
Endocrinology & Metabolism
Sama Hussein, Weina Ju, Stephanie Pizzella, Michael Flory, Chu Chu, Yong Wang, Nanbert Zhong
Summary: The study found that the expression of sFLT-1 and PlGF was reduced in preterm birth cases, while the sFLT-1/PlGF ratio was increased in EVs-EXs, indicating a potential biomarker for predicting preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Ivo Carrasco-Wong, Macarena Aguilera-Olguin, Rodrigo Escalona-Rivano, Delia I. Chiarello, L. Jazel Barragan-Zuniga, Martha Sosa-Macias, Carlos Galaviz-Hernandez, Sebastian San Martin, Jaime Gutierrez
Summary: Preeclampsia is a pregnancy-specific syndrome characterized by sudden increase in blood pressure and poor fetal outcomes. Syncytiotrophoblast stress in early-onset preeclampsia leads to characteristic symptoms, which can be targeted for therapeutic management aiming to improve maternal and fetal outcomes.
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Developmental Biology
Fengyuan Zhang, Mengqi Gu, Pengzheng Chen, Shuting Wan, Qian Zhou, Yuan Lu, Lei Li
Summary: This study found that the concentrations of sFlt-1 and PLGF, as well as the sFlt-1/PLGF ratio, can help distinguish patients with placenta accreta from those with placenta previa.
Article
Cell Biology
Leonardo Ermini, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Isabella Caniggia
Summary: Aberrant ceramide build-up in preeclampsia leads to exuberant autophagy-mediated trophoblast cell death. Lysosome formation is markedly increased in trophoblast cells of early-onset preeclamptic placentae, accompanied by augmented levels of transcription factor EB. Ceramide-induced lysosomal biogenesis and exocytosis contribute to maternal endothelial dysfunction in preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adrian C. C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. T. Spradley, Patricia Dauer, Joey P. P. Granger, Sarosh Rana
Summary: Preeclampsia is a serious complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to identify new compounds that can reduce sFlt-1 and inhibit HIF-1a, a prohypertensive factor. The natural compound luteolin showed the strongest inhibition of sFlt-1 release, with over 95% reduction compared to the control group. Luteolin also reduced HIF-1a expression through the Akt pathway. This makes luteolin a potential novel treatment for preeclampsia.
Article
Biochemistry & Molecular Biology
Adrian C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. Spradley, Patricia Dauer, Joey P. Granger, Sarosh Rana
Summary: Preeclampsia is a dangerous complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to find new compounds to reduce placental sFlt-1 and discovered that luteolin showed the most potent inhibition of sFlt-1 release, with over 95% reduction. Luteolin was found to reduce sFlt-1 through inhibition of HIF-1 alpha, possibly via the Akt pathway.
Article
Developmental Biology
Jing Ma, Haoyue Hu, Miaoling Lin, Lu Chen, Mian Liu, Hong Li, Song Quan
Summary: ELABELA was found to have decreased expression in severe preeclampsia, while promoting trophoblast proliferation. It also showed potential in improving symptoms in a preeclampsia mouse model.
Article
Developmental Biology
YuJia Wang, Yingye Zhang, Yongqi Wu, Yunbiao He, Jingwen Xiang, Jieqiong Huang, Gendie E. Lash, Ping Li
Summary: The downregulation of SIRT1 and the upregulation of senescence- and ECM-related proteins are observed in premature aging placenta with preeclampsia. Activation of SIRT1 can abolish senescence in syncytialized BeWo cells, while knockdown of SIRT1 restores these effects.
Article
Biochemistry & Molecular Biology
Zahra Masoumi, Lena Erlandsson, Eva Hansson, Mattias Magnusson, Eva Mezey, Stefan R. Hansson
Summary: The study found that in preeclampsia (PE) pregnancies, there was no impact on placental hematopoietic stem and progenitor cells homing and erythropoiesis. Non-erythroid alpha-globin mRNA and protein were detected in syncytiotrophoblasts and stroma of PE placenta samples, while normal placenta explants cultured in hypoxia showed upregulation of alpha-globin protein and mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Anca-Florina Tataru-Copos, Mircea Ioachim Popescu, Romina Murvai, Amin El Kharoubi
Summary: This study investigates the correlation between sFlt-1/PlGF ratio and preeclampsia in pregnant women. The results show a positive correlation between sFlt-1/PlGF values and the severity of preeclampsia, which can be used to predict the development of early-onset severe preeclampsia. Additionally, the sFlt-1/PlGF ratio has high accuracy in differentiating preeclampsia patients from pregnant women without symptoms of preeclampsia.
MEDICINA-LITHUANIA
(2022)
Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Review
Medicine, Research & Experimental
Alexandros Velegrakis, Elisavet Kouvidi, Persefoni Fragkiadaki, Stavros Sifakis
Summary: Preeclampsia (PE) is a serious complication of pregnancy with a high incidence rate and causes significant maternal and fetal health risks. Studies have shown that differences in maternal serum levels of angiogenic factors can be used as biomarkers to predict the development of PE. Specifically, the sFlt-1/PlGF ratio has been identified as the optimal predictive tool. However, further research is needed to enhance its clinical applicability and provide universal guidelines for consistent management of PE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Szymon Kozlowski, Anna Stelmaszczyk-Emmel, Iwona Szymusik, Aleksandra Saletra-Bielinska, Robert Brawura-Biskupski-Samaha, Pawel Pietruski, Agnieszka Osinska, Katarzyna Kosinska-Kaczynska
Summary: In this study, it was found that the concentration of sFlt-1 is higher in dichorionic twin pregnancies compared to monochorionic pregnancies. PlGF and sEng levels did not significantly differ between mono- and dichorionic gestation. Additionally, the concentrations of PlGF, sFlt-1 and sEng increased significantly during gestation and were much higher in the third trimester compared to the first trimester.
Article
Biochemistry & Molecular Biology
Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi
Summary: The study demonstrates the involvement of NADPH oxidase in the secretion of sFlt-1 and PlGF in first trimester chorionic villi, and indicates the participation of p38 MAPK pathway in sFlt-1 production and Nox activation. Additionally, the research highlights the major role of placental NADPH oxidase in mediating the signal transduction cascade of sFlt-1 production, as well as the involvement of p38 activation in first trimester placental Nox activity.
