Aldosterone Synthase Inhibition in Hypertension

Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition

(2013) Natallia Strushkevich et al.   MOLECULAR ENDOCRINOLOGY

Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials

(2013) H. Makani et al.   BMJ-British Medical Journal

Study of Aldosterone Synthase Inhibition as an Add-On Therapy in Resistant Hypertension

(2012) Adam D. Karns et al.   Journal of Clinical Hypertension

The Effects of Aldosterone Synthase Inhibition on Aldosterone and Cortisol in Patients With Hypertension: A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study

(2012) Karl Andersen et al.   Journal of Clinical Hypertension

Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension

(2011) David A. Calhoun et al.   CIRCULATION

Aldosterone Synthase Inhibition: A Promising Beginning

(2011) Norman K. Hollenberg   CURRENT HYPERTENSION REPORTS

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

(2010) Christopher M. Adams et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapid Reversal of Left Ventricular Hypertrophy and Intracardiac Volume Overload in Patients With Resistant Hypertension and Hyperaldosteronism

(2010) Krishna Gaddam et al.   HYPERTENSION

Aldosterone Synthase Inhibition With LCI699

(2010) Laurence Amar et al.   HYPERTENSION

Aldosterone Production and Insulin Resistance in Healthy Adults

(2010) Rajesh Garg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HORMONAL AND ELECTROLYTE RESPONSES TO THE ALDOSTERONE SYNTHASE INHIBITOR LCI699 IN SODIUM DEPLETED HEALTHY SUBJECTS

(2010) Joël Menard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel therapeutic targets for hypertension

(2010) Ludovit Paulis et al.   Nature Reviews Cardiology

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Programming of Hypertension

(2009) Rebecca M. Reynolds et al.   HYPERTENSION

Aldosterone-receptor antagonism in hypertension

(2009) Pieter M Jansen et al.   JOURNAL OF HYPERTENSION

Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt

(2009) William B. Lea et al.   KIDNEY INTERNATIONAL

Plasma Aldosterone and Its Relationships With Left Ventricular Mass in Essential Hypertensive Patients With the Metabolic Syndrome

(2008) G. Mule et al.   AMERICAN JOURNAL OF HYPERTENSION

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

(2008) P. Mulder et al.   EUROPEAN HEART JOURNAL

High plasma aldosterone and low renin predict blood pressure increase and hypertension in middle-aged Caucasian populations

(2008) P Meneton et al.   JOURNAL OF HUMAN HYPERTENSION

Aldosterone and mineralocorticoid receptors: Clinical studies and basic biology

(2008) John W. Funder et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fadrozole Reverses Cardiac Fibrosis in Spontaneously Hypertensive Heart Failure Rats: Discordant EnantioselectivityVersusReduction of Plasma Aldosterone

(2007) Monica Minnaard-Huiban et al.   ENDOCRINOLOGY