Journal
CURRENT HYPERTENSION REPORTS
Volume 14, Issue 6, Pages 492-497Publisher
SPRINGER
DOI: 10.1007/s11906-012-0313-4
Keywords
Transient receptor potential channels; Transient receptor potential canonical channels; TRPC channels; Calcium; Cytoskeleton; Scaffolding proteins; Hypertension; Mechanotransduction; Vascular reactivity; Vascular remodeling; Hypertrophy; Heart failure; Podocyte; Focal segmental glomerulosclerosis; Cardiorenal system; End-stage kidney disease
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Funding
- National Heart, Lung, and Blood Institute [R01HL093470]
- MDA
- HHMI
- American Heart Association
- Mandel Foundation
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Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses TRP channels in the cardiovascular and glomerular filtration systems and their role in disease pathogenesis. We describe the regulation of gating of TRPC channels in the cardiorenal system as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of TRP channels in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.
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