Journal
CURRENT GENOMICS
Volume 11, Issue 1, Pages 70-76Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920210790217990
Keywords
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Funding
- EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health
- CIHR [CIHR81086, CIHR84256]
- Canada Research Chair
- WCU program
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Recent advances into the understanding of molecular mechanism of chronic pain have been largely developed through the use of genetic manipulations. This is in part due to the scarcity of selective pharmacological tools, which can be readily solved by creating knockout or transgenic mice. By identifying new genes that are of import, our efforts can then be aimed at studying relevant signaling pathways, and combination of pharmacological manipulations with genetic models can be used to further examine the specific mechanisms involved in chronic pain. In this review, we will examine the genetic models that are currently in use to study chronic pain in the anterior cingulate cortex: knockout mice; transgenic mice; and the strength of combining pharmacology with these genetic models.
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