Review
Behavioral Sciences
Georgios Matis, Pasquale De Negri, Denis Dupoiron, Rudolf Likar, Xander Zuidema, Dirk Rasche
Summary: This article summarizes recommendations made by six pain specialists regarding ziconotide intrathecal analgesia (ITA) and its potential as a first-line alternative to morphine in Europe. The specialists advocate for more European prospective studies on ziconotide to further investigate its low-and-slow dosing strategies and reduce opioid usage among patients.
BRAIN AND BEHAVIOR
(2021)
Review
Virology
Christos Dogrammatzis, Hope Waisner, Maria Kalamvoki
Summary: Viruses encode both structural and non-structural proteins, with non-structural proteins playing important roles in replication, spread, and immune evasion. Understanding non-essential viral factors involves complex studies requiring suitable cell culture systems and in vivo models.
Article
Anesthesiology
Denis Dupoiron, Florent Bienfait, Gabriel Carvajal, Valerie Seegers, Thomas Douillard, Sabrina Jubier-Hamon, Thierry Delorme, Arthur Julienne, Yves Marie Pluchon, Nicolas Ribault, Edmond Nader, Nathalie Lebrec
Summary: The study demonstrated that long-term intrathecal treatment using a multidrug regimen through cervical intrathecal catheters was effective and safe for relieving cancer-related pain. Clinically and statistically significant pain reduction was achieved mainly using a percutaneous lumbar approach in the study population.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Behavioral Sciences
Wangjun Qin, Li Zhao, Botao Liu, Yang Yang, Peng Mao, Liyuan Xu, Pengmei Li, Yongguang Shang, Lei Zhang, Bifa Fan
Summary: This study compares the efficacy, safety, and cost of externally and internally implanted systems for the treatment of refractory cancer pain in China. The results show that the externally implanted system provides similar pain relief to the internally implanted system, but with a shorter implantation time. There is no significant difference in the incidence of complications between the two systems. However, the externally implanted system has a lower initial implantation cost but higher maintenance costs.
BRAIN AND BEHAVIOR
(2023)
Article
Anesthesiology
Shane E. Brogan, Jill E. Sindt, Daniel W. Odell, Amitabh Gulati, Denis Dupoiron
Summary: Pain and suffering related to cancer are challenging issues and deserve optimization of treatment. Intrathecal drug delivery has an established role in the management of refractory cancer pain, but there are significant knowledge gaps in understanding and applying this therapy.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Rana Ajeeb, John R. Clegg
Summary: The proximity and association of cerebrospinal fluid (CSF) and the intrathecal (IT) space with deep targets in the central nervous system (CNS) parenchyma makes IT injection an attractive route for brain drug delivery. However, the effectiveness of intrathecally administered macromolecules in treating neurological diseases is still debated. Our analysis of clinical trials over the past 20 years shows an increasing interest in using IT delivery for the treatment of chronic conditions with biologics. Engineering technologies have not been extensively evaluated in these trials, but recent pre-clinical studies suggest their potential in improving CNS targeting and therapeutic outcome.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Patricia Garcia-Garcia, Ricardo Reyes, Daniel Garcia-Sanchez, Flor Maria Perez-Campo, Jose Carlos Rodriguez-Rey, Carmen Evora, Patricia Diaz-Rodriguez, Araceli Delgado
Summary: This study successfully enhanced the bone density in osteoporotic mice by using aptamer-functionalized nanoparticles carrying SFRP1 silencing GapmeR, without causing any toxic effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qi Fu, Zhongming Lian, Mengya Niu, Yaru Huang, Yanqiu Ai, Long He, Dandan Zhang, Cuixia Zheng, Jian-Jun Yang, Lei Wang, Dandan Tian
Summary: In this study, a near-infrared light-activated nano-therapeutic system was constructed for the concurrent treatment of breast cancer bone metastasis and cancer-induced bone pain (CIBP). The designed nanoplatform effectively destroys tumor cells and reduces CIBP in both in vitro and in vivo experiments. Additionally, it inhibits osteoclast activation, promotes osteoblast differentiation, and accelerates bone repair.
CHINESE CHEMICAL LETTERS
(2024)
Article
Biology
Luisa Zupin, Sergio Crovella
Summary: In this study, blue light was found to significantly reduce HSV-1 replication and increase cell survival in a neuronal cellular model. These findings suggest the potential clinical application of photobiomodulation therapy for treating herpes labialis in pediatric patients.
Article
Oncology
Lei Teng, Junzhu Dai, Hongxue Shao, Liuyuan Zhao, Shiyan Lin, Wenhui Zhang, Huichao Zou
Summary: The study aimed to determine the analgesic efficacy and safety of combining gabapentin with morphine after IDDS implantation. The combination therapy achieved similar analgesic efficacy with lower dose of morphine compared to morphine alone, but had a higher incidence of dizziness and somnolence.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Pharmacology & Pharmacy
Igor Jurak, Maja Cokaric Brdovcak, Lara Djakovic, Ivana Bertovic, Klaudia Knezevic, Martin Loncaric, Antonija Jurak Begonja, Nela Malatesti
Summary: This study demonstrates that activated TMPyP3-C17H35 can effectively inhibit HSV-1 replication and can be further developed as a potential novel treatment and used as a model for studying photodynamic antimicrobial chemotherapy.
Article
Medicine, Research & Experimental
Sheu-Ran Choi, Ho Jae Han, Alvin J. Beitz, Jang-Hern Lee
Summary: Administration of IL-1 beta during the early phase of nerve injury can reduce the expression of Sig-1R in spinal astrocytes, decrease pGluN1 expression, and suppress the development of mechanical allodynia and thermal hyperalgesia, producing an analgesic effect on neuropathic pain.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Anesthesiology
Gabriel Carvajal
Summary: Pancreatic cancer patients often experience high prevalence of pain, requiring strong opioids for treatment. Studies focus on understanding mechanisms and advancements in pain management related to pancreatic cancer pain.
Article
Biochemistry & Molecular Biology
Zhuoying Feng, Fanghang Zhou, Miaomiao Tan, Tingting Wang, Ying Chen, Wenwen Xu, Bin Li, Xin Wang, Xin Deng, Ming-Liang He
Summary: HSV-1 infection enhances the expression of m6A modification-related genes to facilitate viral replication, while inhibiting m6A modification reduces viral replication and reproduction.
Article
Medicine, Research & Experimental
Kelsey R. Pflepsen, Cristina D. Peterson, Kelley F. Kitto, Maureen S. Riedl, R. Scott McIvor, George L. Wilcox, Lucy Vulchanova, Carolyn A. Fairbanks
Summary: The distribution and kinetics of AAV5 vector following lumbar intrathecal injection in mice were evaluated in this study. Results showed rapid distribution of AAV5 particles to all levels of the spinal cord and dorsal root ganglia, with preferential targeting of DRG tissue and possible clearance mechanisms via DRG macrophages.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ling Wang, Yue-Qin Zeng, Juan-Hua Gu, Rui Song, Peng-Hui Cang, Yong-Xuan Xu, Xiao-xia Shao, Li-Jin Pu, Hai-Yun Luo, Xin-Fu Zhou
Summary: Oxidative stress plays a crucial role in diabetic cardiomyopathy, and the novel oral edaravone (OED) has shown potential in alleviating oxidative stress and improving diastolic dysfunction. OED reduced oxidative stress and improved cardiac parameters in type 2 diabetic rats, as well as reduced reactive oxygen species and cell damage in H9c2 cells. These effects were mediated by the activation of the Nrf2 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Bingyu Li, Wei Wang, Yanan Li, Su Wang, Hengjuan Liu, Zhongyuan Xia, Wenwei Gao, Bo Zhao
Summary: Activation of NCOA4-mediated ferritinophagy exacerbates early-stage CIRI and plays a crucial role in the progression of oxidative stress, autophagy, and apoptosis. The cGAS-STING pathway is implicated in regulating NCOA4-mediated ferritinophagy, and its inhibition ameliorates CIRI, attenuated by NCOA4 overexpression.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Mengxuan Zhang, Lei Li, Goce Trajcevski, Andreas Zufle, Xiaofang Zhou
Summary: This paper discusses the challenges and methods for shortest path computation in frequently evolving small-world networks. By adopting Parallel Shortest-distance Labeling (PSL) as the construction method for 2-hop labeling and designing update mechanisms, the query efficiency and index maintenance effectiveness are improved.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Defu Lian, Jin Chen, Kai Zheng, Enhong Chen, Xiaofang Zhou
Summary: One-class collaborative filtering (OCCF) problems are common in recommendation systems, but suffer from data sparsity and lack of negative items. To address these challenges, a ranking-based implicit regularizer is proposed and used in a framework to improve recommendation quality. Efficient algorithms are developed to optimize model parameters and extensive evaluations are conducted on multiple datasets.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2022)
Article
Computer Science, Information Systems
Yunyi Li, Yongjing Hao, Pengpeng Zhao, Guanfeng Liu, Yanchi Liu, Victor S. Sheng, Xiaofang Zhou
Summary: This article proposes an Edge-Enhanced Global Disentangled Graph Neural Network (EGD-GNN) model to capture the relation information between items for global item representation and local user intention learning. Experimental results show that our model can achieve a significant improvement over state-of-the-art baselines and effectively distinguish item features.
ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA
(2023)
Article
Biochemistry & Molecular Biology
Wei Wang, Bo Zhao, Wenwei Gao, Wenqin Song, Jiabao Hou, Lei Zhang, Zhongyuan Xia
Summary: This study found that PINK1-mediated mitophagy and caspase-3/GSDME pathway play important roles in the pathogenesis of postoperative cognitive dysfunction (POCD). Interventional studies using PINK1 silencing and caspase-3 inhibitor showed that PINK1-regulated mitophagy regulates anesthesia and surgery-induced cognitive impairment by affecting the caspase-3/GSDME pathway, providing a promising therapeutic target for POCD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Wei Wang, Wenwei Gao, Lei Zhang, Zhongyuan Xia, Bo Zhao
Summary: This study reveals that SNAP25 plays a protective role in postoperative cognitive dysfunction (POCD) by regulating mitochondrial quality control and reducing apoptosis.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Yu Yang, Hongzhi Yin, Jiannong Cao, Tong Chen, Quoc Viet Hung Nguyen, Xiaofang Zhou, Lei Chen
Summary: Dynamic graphs are graphs whose structure changes over time. Existing approaches only consider dynamic graphs as a sequence of changes in vertex connections, ignoring the asynchronous nature of the dynamics where the evolution of each local structure starts at different times and lasts for various durations. To address this, we propose a novel representation of dynamic graphs as temporal edge sequences associated with joining time of vertices (ToV) and timespan of edges (ToE). We also introduce a time-aware Transformer to embed the dynamic connections and ToEs into learned vertex representations, along with encoding time-sensitive information. Our approach outperforms the state-of-the-art in various graph mining tasks and is efficient for embedding large-scale dynamic graphs.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Yongjing Hao, Tingting Zhang, Pengpeng Zhao, Yanchi Liu, Victor S. Sheng, Jiajie Xu, Guanfeng Liu, Xiaofang Zhou
Summary: Sequential recommendation has become crucial in various Internet applications. Existing methods overlook the transition patterns between the features of items, while our proposed model enhances recommendation performance through learning feature-level and item-level sequences.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Mohsen Saaki, Saeid Hosseini, Sana Rahmani, Mohammad Reza Kangavari, Wen Hua, Xiaofang Zhou
Summary: This study highlights the importance of finding suitable individuals to answer questions using short content and identifies the challenges involved. The authors propose a novel embedding approach and recommendation system to overcome these challenges, and provide experimental results to demonstrate its effectiveness.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Neurosciences
Yanan Li, Qianni Shen, Lidan Huang, Bingyu Li, Yuxi Zhang, Wei Wang, Bo Zhao, Wenwei Gao
Summary: This study investigates the role of GRSF1 in cerebral ischemia-reperfusion injury (CIRI) and its specific mechanisms. The researchers found that GRSF1 expression was low in CIR mice, while senescence-related markers were increased. Overexpression of GRSF1 improved infarct volume and neurological function, and suppressed apoptosis. The results suggest that cellular senescence contributes to CIRI, and GRSF1 can protect against reperfusion injury by regulating GPX4.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Yao Tian, Tingyun Yan, Xi Zhao, Kai Huang, Xiaofang Zhou
Summary: This paper proposes a novel indexing approach called LIMS, which uses data clustering, pivot-based data transformation techniques, and learned indexes to support efficient similarity query processing in metric spaces. LIMS partitions the underlying data into clusters with relatively uniform data distribution and utilizes a small number of pivots for data redistribution. Similar data are mapped into compact regions with totally ordinal mapped values. Machine learning models approximate the position of each data record on disk, and efficient algorithms are designed for range queries, nearest neighbor queries, and index maintenance with dynamic updates.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Yan Zhao, Kai Zheng, Yunchuan Li, Jinfu Xia, Bin Yang, Torben Bach Pedersen, Rui Mao, Christian S. Jensen, Xiaofang Zhou
Summary: In spatial crowdsourcing, mobile users are involved in spatio-temporal tasks that require travel to specific locations. The task assignment in spatial crowdsourcing is a challenging problem that needs to be addressed to maximize profits. This study introduces a profit-driven task assignment problem and proposes various algorithms, including an optimal algorithm based on tree decomposition and greedy algorithms based on random tuning optimization. Additionally, a heuristic algorithm based on ant colony optimization is provided to balance effectiveness and efficiency. Extensive experiments using real and synthetic data are conducted to evaluate the proposed methods.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Wei Wang, Bo Zhao, Wenwei Gao, Wenqin Song, Jiabao Hou, Lei Zhang, Zhongyuan Xia
Summary: PTEN-induced kinase 1 (PINK1)-mediated mitophagy and caspase-1/gasdermin D canonical pyroptosis pathways are involved in the development of postoperative cognitive dysfunction (POCD). Gasdermin E (GSDME), which can be activated by caspase-3, is highly expressed in the brain and neurons. This study investigates the role of PINK1-dependent mitophagy in postoperative cognitive impairment through caspase-3/GSDME.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Cell Biology
Wei Wang, Wenwei Gao, Ping Gong, Wenqin Song, Xueshan Bu, Jiabao Hou, Lei Zhang, Bo Zhao
Summary: Inhibiting TNFAIP1-mediated degradation of SNAP25 may be a promising therapeutic approach for mitigating postoperative cognitive decline.
CELL COMMUNICATION AND SIGNALING
(2023)