Review
Chemistry, Inorganic & Nuclear
Lukasz Kiraga, Paulina Kucharzewska, Stephen Paisey, Lukasz Cheda, Anita Domanska, Zbigniew Rogulski, Tomasz P. Rygiel, Alberto Boffi, Magdalena Krol
Summary: This review paper discusses the pivotal role of nuclear imaging techniques in evaluating the effectiveness of immune cell-based therapies, focusing on tracking cells and their ability to home to the target tissue. It compares different types of radiotracers, outlines various ways of immune cell labeling, and provides the latest examples for the use of nuclear imaging techniques in both preclinical studies and clinical settings.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Engineering, Environmental
Peipei Xu, Gang Zhao, Zhengye Gu, Gang Wei, Kezhen Zhang, Chunxue Yi, Shanyi Guang, Hongyao Xu
Summary: This study designed and developed a novel nanohybrid molecule PRHAP based on POSS, which has the ability to detect Hg2+ in solution with high sensitivity and facilitate cellular repair. Additionally, PRHAP can detoxify Hg2+ and monitor it in mice, showing promising potential for various applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Alexandra Marisa Targovnik, Jorge Alejandro Simonin, Gregorio Juan Mc Callum, Ignacio Smith, Franco Uriel Cuccovia Warlet, Maria Victoria Nugnes, Maria Victoria Miranda, Mariano Nicolas Belaich
Summary: Baculoviruses, as insect pathogens, have been widely used in biotechnological applications with various biological engineering features, including pest control, recombinant protein expression systems, mammalian gene delivery, and antigenic protein display systems. BEVS and BacMam technologies, due to their ease of use and availability as commercial systems, have been widely introduced in academia and the pharmaceutical industry as essential tools for developing biological products.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Immunology
Qiaonan Hong, Jian Liu, Yuquan Wei, Xiawei Wei
Summary: Vaccination is an effective strategy to control epidemics, and the baculovirus expression vector system (BEVS) is a promising technology for vaccine production due to its safety and rapid production. This review provides an overview of the development history of BEVS, the procedures for preparing recombinant protein vaccines using the BEVS platform, and the features and limitations of this platform. The progress of BEVS platform-related research, particularly in the field of vaccine, is highlighted, along with a future prospect for BEVS in vaccine manufacturing.
Article
Acoustics
Efthymios Maneas, Andreas Hauptmann, Erwin J. Alles, Wenfeng Xia, Tom Vercauteren, Sebastien Ourselin, Anna L. David, Simon Arridge, Adrien E. Desjardins
Summary: A framework based on a convolutional neural network (CNN) is proposed to maintain spatial resolution with fewer tracking transmissions and enhance signal quality. Experimental results show that the performance of needle localization can be significantly improved even with an eightfold reduction in tracking transmissions. This framework will greatly improve the performance of ultrasonic tracking, leading to faster image acquisition rates and increased localization accuracy.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Chemistry, Analytical
Li Fan, Xiaodong Wang, Qi Zan, Lifang Fan, Feng Li, Yongming Yang, Caihong Zhang, Shaomin Shuang, Chuan Dong
Summary: The research team synthesized a sensitive LD-TTP fluorescent probe that can efficiently detect and monitor changes in lipid droplet polarity, holding great potential for clinical diagnosis of lipid droplet polarity-related diseases.
ANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Adolfo Cruz-Resendiz, Gonzalo Acero, Alicia Sampieri, Goar Gevorkian, Carolina Salvador, Laura Escobar, Margarita Jacaranda Rosendo-Pineda, Mara Medeiros, Luis Vaca
Summary: Polyhedrins are viral proteins that form occlusion bodies to protect virus particles and enhance immune response to specific antigens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Wu Qingsheng, Li Yuanyuan
Summary: This study presents a simple, accurate, low-cost, and highly repeatable flow cytometry method for rapid detection of baculovirus titer. By staining cells with a fluorescently labeled antibody and analyzing with flow cytometry, the ratio of infected to uninfected cells can be determined, enabling accurate titer determination.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Pharmacology & Pharmacy
Phuoc-Vinh Nguyen, Emilie Allard-Vannier, Nicolas Aubrey, Christine Labrugere-Sarroste, Igor Chourpa, Julien Sobilo, Alain Le Pape, Katel Herve-Aubert
Summary: This study successfully developed a radiolabeling method using DTPA chemistry to track NM-scFv in in vivo conditions without impacting its active targeting and physicochemical properties. The optimized ratio achieved high radiolabeling yield, and the labeled NM-scFv showed good siRNA protection capacity and comparable transfection efficiency. Furthermore, it could track NM-scFv in vivo with nuclear imaging and demonstrated high in vivo stability.
Article
Biochemistry & Molecular Biology
Ning Ma, Ye Liu, Dandan Chen, Changfeng Wu, Zihui Meng
Summary: This study developed fluorescent semiconductor polymer dots (Pdots) for labeling and tracking mesenchymal stem cell-derived exosomes (MSC-Exos). The labeled MSC-Exos mainly accumulated in the residual liver tissue and showed therapeutic effects in terms of inhibiting inflammatory responses, promoting cell proliferation, and resisting apoptosis, which could accelerate postoperative liver function recovery.
Article
Multidisciplinary Sciences
Fufeng Qiao
Summary: A DCNN-LSTM model is proposed to recognize and track table tennis trajectory, which improves performance by 23.17% compared to traditional methods, offering potential applications in live matches.
Article
Education & Educational Research
Fengxiang Song, Cailing Han, Bin Liu, Yuxue Qiu, Haitao Hou, Xiaoqiong Yan, Liqin Deng
Summary: This study used pig larynx and trachea models to simulate and practice cricothyrotomy, helping anesthesiologists master this technique quickly. Through repeated practice, the operation time was significantly reduced and participants were highly satisfied with the training course. Thus, the pig larynx and trachea model is highly effective for simulating and practicing cricothyrotomy.
BMC MEDICAL EDUCATION
(2023)
Article
Microbiology
Baojing Lu, Qi Tang, Qianyun Wang, Xuejuan Liu, Hui Peng, Binbin Zhu, Li Xie, Zeng Li, Hanzhong Wang, Zhenhua Zheng, Linding Wang, Bao Li
Summary: In this study, a new approach to rescue EV71 using a baculovirus expression system in vitro and in vivo was established. The recombinant baculovirus successfully recovered EV71 in mammalian cells and mouse brain, providing a safe and convenient platform for fundamental research and a strategy to rescue viruses that lack suitable cell culture and animal models.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Automation & Control Systems
Liqiang Yao
Summary: This paper focuses on stability theorems of random nonlinear time delay systems and their application. On one hand, some noise-to-state practical stability theorems are improved for random nonlinear systems with time delay in this paper. On the other hand, the state feedback tracking control problem is investigated to show the applicability of improved stability theorems in this paper.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2022)
Article
Materials Science, Multidisciplinary
Liao Zhang, Yutao Zhang, Weijie Chi, Chenxu Yan, Zijun Zhao, Xiaogang Liu, Wei-Hong Zhu, Zhiqian Guo
Summary: This study proposes a pi-conjugated crossbreeding dyad strategy to develop novel NIR-II dyes with small molecular weights, high stability, and good brightness, greatly expanding the high-resolution activatable in vivo imaging tools for intact tissues and living animals.
ACS MATERIALS LETTERS
(2022)