High-Mobility Group Box-1 Modulates the Expression of Inflammatory and Angiogenic Signaling Pathways in Diabetic Retina

The Proinflammatory Cytokine High-Mobility Group Box-1 Mediates Retinal Neuropathy Induced by Diabetes

(2014) Ahmed M. Abu El-Asrar et al.   MEDIATORS OF INFLAMMATION

Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1–RAGE interaction

(2014) Yu Okuma et al.   NEUROPHARMACOLOGY

Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats

(2014) Gu Gong et al.   PLoS One

Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis

(2014) Hye Young Kim et al.   PLoS One

High-Mobility Group Box-1 Induces Decreased Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in the Diabetic Retina

(2013) Ahmed M. Abu El-Asrar et al.   MEDIATORS OF INFLAMMATION

TheERK1/2Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina

(2013) Ghulam Mohammad et al.   Journal of Diabetes Research

Establishing the role of tyrosine kinase 2 in cancer

(2013) Caroline Übel et al.   OncoImmunology

High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina

(2012) Ghulam Mohammad et al.   EXPERIMENTAL EYE RESEARCH

Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells

(2012) Manxiang Li et al.   FEBS LETTERS

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion

(2012) Seung-Woo Kim et al.   NEUROBIOLOGY OF DISEASE

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

(2012) J R van Beijnum et al.   ONCOGENE

Vascular Endothelial Growth Factor A in Intraocular Vascular Disease

(2012) Joan W. Miller et al.   OPHTHALMOLOGY

Ocular Application of the Kinin B1 Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats

(2012) Mylène Pouliot et al.   PLoS One

TNF-α induces early growth response gene-1 expression via ERK1/2 activation in endothelial cells

(2011) Yanli Cao et al.   ACTA DIABETOLOGICA

High-Mobility Group Box-1 Mediates Toll-Like Receptor 4–Dependent Angiogenesis

(2011) Qing Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells

(2011) Jingqi Yan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells

(2011) M. Lin et al.   DIABETOLOGIA

Basic fibroblast growth factor regulates glucose metabolism through glucose transporter 1 induced by hypoxia-inducible factor-1α in adipocytes

(2011) Yoshitaka Kihira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

(2011) Xinguo Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats

(2011) Masatoshi Ohnishi et al.   NEUROPHARMACOLOGY

Early Growth Response-1 Induces and Enhances Vascular Endothelial Growth Factor-A Expression in Lung Cancer Cells

(2010) Hiroaki Shimoyamada et al.   AMERICAN JOURNAL OF PATHOLOGY

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells

(2010) Zheng-Gang Luan et al.   IMMUNOBIOLOGY

Placenta Growth Factor-induced Early Growth Response 1 (Egr-1) Regulates Hypoxia-inducible Factor-1α (HIF-1α) in Endothelial Cells

(2010) Nitin Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tempering the wrath of RAGE: An emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation

(2009) Shi Fang Yan et al.   ANNALS OF MEDICINE

Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury

(2009) Shan Zeng et al.   JOURNAL OF HEPATOLOGY

Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells

(2009) Lara Campana et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hypoxic stress-induced changes in adrenergic function: role � of HIF1α

(2009) T. C. Tai et al.   JOURNAL OF NEUROCHEMISTRY

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

(2008) Judy R. van Beijnum et al.   ANGIOGENESIS

Early Growth Response-1 Regulates Angiopoietin-1-Induced Endothelial Cell Proliferation, Migration, and Differentiation

(2008) Nelly A. Abdel-Malak et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia enhances CXCR4 expression favoring microglia migration via HIF-1α activation

(2008) Xubu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The transcription factor Egr1 regulates the HIF-1α gene during hypoxia

(2008) Sabina Sperandio et al.   MOLECULAR CARCINOGENESIS

Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives

(2008) Sally A. Madsen-Bouterse et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS