Article
Ophthalmology
Sarah Thiele, Jennifer Nadal, Maximilian Pfau, Marlene Sassmannshausen, Monika Fleckenstein, Frank G. Holz, Matthias Schmid, Steffen Schmitz-Valckenberg
Summary: The study identified structural precursor lesions in eyes with intermediate AMD that were significantly associated with subsequent GA progression rates, with RPD (phenotype 2) being linked to the fastest GA enlargement. This highlights the prognostic relevance of intermediate AMD phenotyping for predicting GA progression.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Sainan Xiao, Wenmin Sun, Xueshan Xiao, Shiqiang Li, Hualei Luo, Xiaoyun Jia, Jiamin Ouyang, Xueqing Li, Yingwei Wang, Yi Jiang, Panfeng Wang, Qingjiong Zhang
Summary: Almost all rare RS1 variants were found to be potential pathogenic, with all patients with RS1 pathogenic variants showing detectable characteristics in the macula and/or peripheral retina. These findings may be valuable for clinical diagnosis and genetic testing of retinoschisis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Virginia Mares, Ursula Margarethe Schmidt-Erfurth, Oliver Leingang, Philipp Fuchs, Marcio B. Nehemy, Hrvoje Bogunovic, Daniel Barthelmes, Gregor S. Reiter
Summary: This study uses artificial intelligence technology to predict treatment requirements, visual acuity, and morphological outcomes in patients with neovascular age-related macular degeneration. By processing spectral-domain optical coherence tomography data and using a deep learning algorithm for segmentation, future treatment requirements and morphological outcomes can be accurately predicted.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Neil M. Bressler, Miroslav Veith, Jan Hamouz, Jan Ernest, Dominik Zalewski, Jan Studnicka, Attila Vajas, Andras Papp, Gabor Vogt, James Luu, Veronika Matuskova, Young Hee Yoon, Tamas Pregun, Taehyung Kim, Donghoon Shin, Inkyung Oh, Hansol Jeong, Mercy Yeeun Kim, Se Joon Woo
Summary: This study provides longer-term data on the efficacy, safety, immunogenicity, and pharmacokinetics of ranibizumab biosimilar SB11 compared with the reference ranibizumab (RBZ) in neovascular age-related macular degeneration (nAMD) patients. The results support the biosimilarity established between SB11 and RBZ.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Kai Lyn Goh, Himeesh Kumar, Xavier Hadoux, Maxime Jannaud, Carla Abbott, Lauren Hodgson, Luba Robman, Galina Makeyeva, Peter Van Wijngaarden, Robyn Guymer, Zhichao Wu
Summary: This study aimed to investigate the additional prognostic value of quantifying the extent of hyperpigmentary abnormalities (HPAs) defined by color fundus photography (CFP) and their association with visual sensitivity in individuals with intermediate age-related macular degeneration (AMD). The results showed that quantifying the extent of HPAs did not improve the prediction of late AMD development compared to the presence alone, and the extent of HPAs was associated with localized reductions in visual sensitivity. Overall, these findings suggest that quantifying the extent of HPAs provides little additional information for predicting AMD progression but serves as an imaging biomarker for visual dysfunction.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Simone Tzaridis, Kristina Hess, Martin Friedlander, Frank G. Holz
Summary: OCT-A is useful for monitoring NV-progression and treatment effects in MacTel, providing advantages over conventional B-scan OCT imaging.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Feihui Zheng, Jacqueline Chua, Mengyuan Ke, Bingyao Tan, Marco Yu, Qinglan Hu, Chui Ming Gemmy Cheung, Marcus Ang, Shu Yen Lee, Tien Yin Wong, Snec Retina Group, Leopold Schmetterer, Chee Wai Wong, Quan Hoang
Summary: The study used SS-OCTA to quantify retinal and choriocapillaris microvasculature in highly myopic eyes with myopic macular degeneration. The results showed that retinal perfusion density decreased with increasing severity of MMD, while choriocapillaris signal voids were mainly associated with eye axial length rather than MMD severity.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Assaf Hilely, Adrian Au, Won Ki Lee, Miri Fogel Levin, Dinah Zur, Veronica Romero-Morales, Ahmad Santina, Jong Suk Lee, Anat Loewenstein, David Sarraf
Summary: This study describes the optical coherence tomography features of pachyvitelliform maculopathy (PVM) associated with pachychoroid disease. The results show that PVM can be detected with optical coherence tomography and presents hyperautofluorescence in fundus autofluorescent imaging. The visual acuity declines and macular atrophy may develop in patients with PVM. The study suggests a possible pathogenesis of RPE dysfunction secondary to a thick choroid in PVM.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Melina Cavichini, Kunny C. Dans, Mahima Jhingan, Manuel J. Amador-Patarroyo, Shyamanga Borooah, Dirk-Uwe Bartsch, Eric Nudleman, William R. Freeman
Summary: This study retrospectively reviewed 152 eyes of 106 AMD patients and found that OCTA had a specificity and sensitivity of 85.4% and 79.3%, respectively, in identifying the presence or absence of CNV. However, OCTA was only 69.5% accurate in recognizing active CNV.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Zhiyan Xu, Weisen Wang, Jingyuan Yang, Jianchun Zhao, Dayong Ding, Feng He, Di Chen, Zhikun Yang, Xirong Li, Weihong Yu, Youxin Chen
Summary: The study aimed to investigate the efficacy of a bi-modality deep convolutional neural network (DCNN) framework for categorising age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) from colour fundus images and optical coherence tomography (OCT) images. The results showed that the bi-modal DCNN demonstrated high accuracy, sensitivity, and specificity in classifying AMD and PCV, outperforming human experts and showing promising prospects in the field of public health.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Liangbo L. Shen, Mengyuan Sun, Aneesha Ahluwalia, Michael M. Park, Benjamin K. Young, Eleonora M. Lad, Cynthia Toth, Lucian Del Priore
Summary: This study tracked the progression of eyes with geographic atrophy (GA) involving the central 1 mm diameter zone and found that the central residual effective radius (CRER) declined linearly over approximately 13 years. This finding suggests that CRER could serve as an anatomical endpoint in future clinical trials aiming to preserve the central zone.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Thales Antonio Cabral de Guimaraes, Malena Daich Varela, Michalis Georgiou, Michel Michaelides
Summary: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world, with promising treatment prospects for wet AMD but challenges remain for dry AMD. Various therapeutic approaches are being investigated, including drugs with antioxidative properties, complement cascade inhibitors, gene therapy, etc., with promising results from early clinical trials.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Rachael L. Niederer, Priya D. Samalia, Yi-Hsing Chen, Jonathan K. S. Goh, Elisa Eleanor Cornish, Stephen Guest, Peter J. McCluskey, Lyndell L. Lim, Joanne L. Sims, Susan Lightman, Oren Tomkins-Netzer
Summary: Acute posterior multifocal placoid pigment epitheliopathy is a rare but important disease associated with life-threatening complications. The study aimed to determine the incidence of neurological complications and risk factors for stroke and TIA associated with this disease. Results showed that stroke and TIA occurred in 11.7% of subjects, with older age being the only significant risk factor. Vision loss occurred in 7 eyes, and recurrence was observed in 16.7% of patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Cristina Arpa, Hagar Khalid, Shruti Chandra, Siegfried Wagner, Katrin Fasler, Livia Faes, Pakinee Pooprasert, Reena Chopra, Gabriella Moraes, Konstantinos Balaskas, Pearse A. Keane, Sobha Sivaprasad, Dun Jack Fu
Summary: This study reveals that patients with neovascular age-related macular degeneration (nAMD) receiving anti-VEGF therapy may retain good vision in the long term, with early treatment associated with better visual outcomes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Lucie Tichotova, Hana Studenovska, Goran Petrovski, Stepan Popelka, Yaroslav Nemesh, Miroslava Sedlackova, Saskia Drutovic, Sonali Rohiwal, Pavla Jendelova, Slaven Erceg, Anna Brymova, Ana Artero-Castro, Lyubomyr Lytvynchuk, Zbynek Stranak, Zdenka Ellederova, Jan Motlik, Taras Ardan
Summary: RPE replacement is an effective modern option for saving vision in cases of retinal degeneration caused by dysfunction of the retinal pigment epithelium. Cultivating RPE cells on PDLLA nanofibrous membranes results in better maturation and long-term survival, making them a plausible source for replacing non-functioning RPEs during cell therapy.
ACTA OPHTHALMOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Juha M. T. Hyttinen, Janusz Blasiak, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is a complex disease characterized by damage to the retina and is a major cause of vision loss in elderly people. This review explores the role of non-coding RNAs in regulating mitochondrial function and antioxidant stress response in AMD. These molecules have the potential to be used as diagnostic markers and therapeutic targets for AMD and other oxidative stress-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gerard Boix-Lemonche, Richard M. Nagymihaly, Essi M. Niemi, Natasha Josifovska, Stian Johansen, Morten C. Moe, Hanne Scholz, Goran Petrovski
Summary: Injury of the cornea is a complex biological process that can be facilitated by mesenchymal stromal cells (MSCs) and tissue equivalents. This study presents a new tissue-engineering strategy for corneal stroma regeneration using cellularized 3D bioprinted hydrogel constructs implanted into cultured porcine corneas. The experiment successfully combines laboratory-based methods with patient-care practice to produce a cell-laden tissue equivalent for corneal implantation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Natasha Josifovska, Sofija Andjelic, Lyubomyr Lytvynchuk, Xhevat Lumi, Tanja Ducic, Goran Petrovski
Summary: Synchrotron radiation-based Fourier Transform Infrared (SR-FTIR) microspectroscopy is a technique used for non-destructive and chemically sensitive detection of biomolecular changes in cells. This study investigated the effects of autophagy and oxidative stress on human primary retinal pigment epithelium (hRPEs), using SR-FTIR microspectroscopy to analyze the changes in nucleic acids, proteins, carbonyl groups, and lipids. The results can be used to study drug discovery targeting autophagy and oxidative stress in age-related macular degeneration (AMD).
Review
Biochemistry & Molecular Biology
Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Georgina Faura, Lars Eide, Ljubo Znaor, Slaven Erceg, Knut Stieger, Jan Motlik, Kapil Bharti, Goran Petrovski
Summary: The retinal pigment epithelium (RPE) plays a crucial role in maintaining the normal physiology of the eye, and damage to the RPE can lead to degenerative eye diseases. Currently, stem cell-derived RPE transplantation is being explored for treating early stages of age-related macular degeneration (AMD). This article focuses on developmental studies and stem cell-based research to understand the biology and derive functional RPEs.
Review
Biology
Ambroz Pusnik, Goran Petrovski, Xhevat Lumi
Summary: Dysphotopsias, divided into positive and negative types, are common visual disturbances that happen after cataract surgery. Positive dysphotopsias include glare, light streaks, starbursts, light arcs, rings, haloes, or flashes of light. Negative dysphotopsias appear as an arc-shaped shadow or line in the visual field. While positive dysphotopsias occur in a higher percentage of patients, persistent symptoms are rare. Negative dysphotopsias have a lower incidence rate, but more cases experience symptoms that persist beyond one year postoperatively.
Letter
Ophthalmology
Andrii Ruban, Beata Eva Petrovski, Goran Petrovski, Lyubomyr M. Lytvynchuk
CLINICAL OPHTHALMOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Filippo Confalonieri, Natasha Josifovska, Gerard Boix-Lemonche, Ingar Stene-Johansen, Ragnheidur Bragadottir, Xhevat Lumi, Goran Petrovski
Summary: Vitreous substitutes are essential tools in vitreoretinal surgery, serving the crucial functions of displacing fluid and ensuring retina adhesion. Surgeons now have a wide range of substitutes to choose from, making it challenging to determine the ideal tamponade for optimal outcomes. This article provides an overview of the physical and chemical properties of vitreous substitutes, their clinical applications, and surgical techniques. The future developments in vitreous substitutes are extensively discussed, with a focus on desired outcomes and biomaterials technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
John Kim Hiller, Elise Mork Sandas, Helge Rootwelt, Anja Osteby Vassli, Tor Paaske Utheim, Morten Carstens Moe, Katja Benedikte Presto Elgstoen, Goran Petrovski
Summary: This study explored the diffusion capacities between the anterior and vitreous chambers in a novel ex vivo pig eye model using stable isotope-labeled acylcarnitines and mass spectrometry analysis. The results showed a distinct diffusion pattern of molecules with different molecular size and hydrophobicity within and between the two chambers. This model can be valuable for optimizing therapeutic molecule choices and designs for intravitreal, intracameral, and topical treatments in the future.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Vidas Raudonis, Arturas Kairys, Rasa Verkauskiene, Jelizaveta Sokolovska, Goran Petrovski, Vilma Jurate Balciuniene, Vallo Volke
Summary: This study presents a novel method for automatically detecting microaneurysms in color fundus images. The proposed method consists of three main steps: image breakdown into smaller patches, inference to segmentation models, and reconstruction of the predicted segmentation map. The proposed segmentation method utilizes an ensemble of three different deep networks, including U-Net, ResNet34-UNet, and UNet++. The performance evaluation is based on Dice score and IoU values, and the ensemble-based model achieves higher scores compared to other network architectures. The proposed ensemble-based model demonstrates high potential for the practical application of early-stage diabetic retinopathy detection in color fundus images.
Article
Genetics & Heredity
Xhevat Lumi, Filippo Confalonieri, Metka Ravnik-Glavac, Katja Goricar, Tanja Blagus, Vita Dolzan, Goran Petrovski, Marko Hawlina, Damjan Glavac
Summary: This study examined the relationship between specific genetic variations and the risk of developing proliferative vitreoretinopathy (PVR) after surgery. The study analyzed single nucleotide polymorphisms (SNPs) in genes related to inflammation and oxidative stress, which are associated with PVR pathways, in 192 patients with primary rhegmatogenous retinal detachment (RRD) who underwent 3-port pars plana vitrectomy (PPV). The study found that certain SNPs, SOD2 rs4880 and IL1B rs1071676, were significantly associated with PVR risk. Carriers of the IL1B rs1071676 GG allele appeared to have better postoperative visual acuity among patients without PVR. These findings suggest that genetic variations may play a role in the development of PVR after surgery.
Article
Cell Biology
Jovana Bisevac, Morten Carstens Moe, Liv Drolsum, Olav Kristianslund, Goran Petrovski, Agate Noer
Summary: The study aimed to investigate if a new technique of human amniotic membrane (HAM) preparation, which mimics the crypts in the limbus, enhances the number of progenitor cells cultured ex vivo. The results demonstrated that the crypt-like HAMs expressed higher levels of progenitor markers p63 alpha, SOX9, and proliferation marker Ki-67 compared to flat HAMs, but no difference was found for the quiescence marker CEBPD. This novel HAM preparation method increased the number of progenitor cells expanded in the crypt-like HAM compared to cultures on the conventional flat HAM.
Article
Biochemistry & Molecular Biology
Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu Kauppinen
Summary: Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Inhibition of PROLY-OLIGOPEPTIDASE (PREP) by KYP-2047 has been shown to reduce oxidative stress and inflammation, and clear cellular protein aggregates.
Review
Biology
Filippo Confalonieri, Vanessa Ferraro, Alessandra Di Maria, Alessandro Gaeta, Jose Luis Vallejo-Garcia, Paolo Vinciguerra, Xhevat Lumi, Goran Petrovski
Summary: A systematic review was conducted on the use of antiplatelets and/or anticoagulants in vitreoretinal surgery. The findings suggest that the benefits of using these medications seem to outweigh the disadvantages, which are mainly related to postoperative hemorrhagic complications.
Review
Medicine, General & Internal
Filippo Confalonieri, Gianmaria Barone, Vanessa Ferraro, Giacomo Ambrosini, Alessandro Gaeta, Beata Eva Petrovski, Xhevat Lumi, Goran Petrovski, Alessandra Di Maria
Summary: This study conducted a systematic review on the timing of pars plana vitrectomy (PPV) in vitreous hemorrhage (VH) and concluded that early PPV may be a reasonable approach in selected cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
