Article
Ophthalmology
Sunil Shah, Debarun Dutta, Ankur Barua, Ludger Hanneken, Shehzad A. Naroo
Summary: The study aimed to determine the effects of Tixel (R) treatment on dry eye disease. The results showed that Tixel treatment significantly improved dry eye symptoms and had no adverse events.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Medicine, General & Internal
Paola De La Parra-Colin, Karen Palacios-Aguirre, Andrea Perez-Pria-Kasusky, Rolando Espinosa-Morales, Alberto Hidalgo-Bravo
Summary: The study found that tear meniscus osmolarity measured by TearLab (R) showed low sensitivity, low specificity, and limited agreement with the TFOS DEWS II composite reference standard for dry eye disease diagnosis in patients with rheumatoid arthritis.
Article
Ophthalmology
Jack Greiner, Gui-shuang Ying, Maxwell Pistilli, Maureen G. Maguire, Penny A. Asbell
Summary: The purpose of this study was to determine the relationships between tear osmolarity levels and the severity of signs and symptoms of dry eye disease, as well as the changes in tear osmolarity with changes in signs and symptoms. The study found that tear osmolarity was weakly correlated with dry eye disease signs, and the changes in tear osmolarity were not associated with changes in signs and symptoms of dry eye disease.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Review
Medicine, General & Internal
Anthony J. Bron, Catherine Willshire
Summary: Systemic dehydration is common in the elderly, leading to high morbidity and mortality. Tear osmolarity may serve as a potential indicator of systemic dehydration, but further research is needed for confirmation.
Article
Biochemistry & Molecular Biology
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, Masatoshi Hirayama, Yoko Ogawa, Kazuno Negishi, Shigeto Shimmura
Summary: The tear film stability of a rabbit dry eye model induced by dacryoadenectomy was assessed in this study. The results showed that this model partially captured the phenotypes of human short TBUT-type dry eye, making it a potentially useful animal model for investigating potential drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Maria T. Iradier, Maria Angeles del Buey, Cristina Peris-Martinez, Priscilla Cedano, David P. Pinero
Summary: This study found that IPL-based treatment can significantly improve tear film osmolarity and meibum quality in dry eyes associated with Meibomian gland dysfunction, and the potential therapeutic effect can be predicted. A linear model considering MGD level, OSDI, and NIBUT can be used to predict treatment outcomes before therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Joon Young Hyon, Sang Beom Han
Summary: Dry eye disease is a global public health problem that impairs quality of life and poses economic burden. Inflammation plays a key role in the worsening of the disease, and besides anti-inflammatory medications, vitamin supplementation may also be effective.
APPLIED SCIENCES-BASEL
(2022)
Article
Ophthalmology
Paramdeep Bilkhu, James Wolffsohn, Christine Purslow
Summary: The study found that concentration task and treatment had different effects on tear film evaporation rate, tear meniscus height, symptomology, etc. Tear film lipid layer thickness, non-invasive tear film break-up time and tear meniscus height may be key clinical metrics that drive ocular comfort.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Martina Menchini, Francesco Sartini, Michele Figus, Giovanna Gabbriellini
Summary: In patients with moderate to severe primary Sjogren syndrome-related dry eye disease, short-term treatment with pulsed low-dose hydrocortisone sodium phosphate eye drops improves symptoms and signs of dry eye disease without affecting intraocular pressure.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Maria H. J. Hollander, Jan Willem R. Pott, Konstantina Delli, Arjan Vissink, Rutger H. Schepers, Johan Jansma
Summary: The study found that upper blepharoplasty, with or without removal of a strip of orbicularis oculi muscle, can alleviate dry eye symptoms in patients, while not significantly affecting tear dynamics.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biology
Hung-yin Lai, Alexander Chen, Po-chiung Fang, Hun-ju Yu, Ming-tse Kuo
Summary: This study compared tear film viscosity in Sjogren and non-Sjogren dry eye diseases. They found that Sjogren patients had lower tear film viscosity indices and higher symptom severity. The researchers concluded that tear film viscosity indices can be useful in early detection of Sjogren dry eye disease.
Article
Ophthalmology
Morten Schjerven Magno, Tishelle Daniel, Mathias Kaurstad Morthen, Harold Snieder, Nomdo Jansonius, Tor P. Utheim, Christopher J. Hammond, Jelle Vehof
Summary: This study found alcohol use to be a risk factor for dry eye disease in females, while it had a protective effect in males. The results highlight the importance of considering sex-specific effects in studies on dry eye disease.
Article
Biochemistry & Molecular Biology
Kristina Krajcikova, Agnieszka Balicka, Maria Lapsanska, Alexandra Trbolova, Zuzana Gulasova, Daria Kondrakhova, Vladimir Komanicky, Adriana Rasiova, Vladimira Tomeckova
Summary: Dry eye disease is a chronic ophthalmological disease for which current therapy focuses on symptom suppression. Polyphenols have shown potential in improving dry eye disease therapy. This study aimed to target pathophysiological mechanisms by adding fisetin to the cyclosporine treatment protocol, but it was found that fisetin did not restore tear production but influenced molecular pathological events through MMP-9.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando
Summary: This review describes the main categories of ingredients in tear substitutes and their effects on the ocular surface. It also provides insights into how to select the appropriate tear substitute formulations based on the predominant causes of dry eye disease (DED).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Katsuhide Yamasaki, Yohei Mizuno, Yoshiyuki Kitamura, David J. McCanna, William Ngo, Lyndon W. Jones
Summary: All three solutions significantly reduced P. aeruginosa on direct-contact surfaces. The PVP-I system was more effective against P. aeruginosa on non-contact surfaces than the hydrogen peroxide system or the chemical multipurpose system, and capable of inhibiting regrowth of P. aeruginosa for at least 7 days post-disinfection.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Negar Babaei Omali, Lakshman. N. Subbaraman, Miriam Heynen, Mark Lada, Kristy Canavan, Zohra Fadli, William Ngo, Lyndon Jones
Summary: Lipid deposition was significantly higher in the asymptomatic group compared to symptomatic wearers. Cholesteryl ester deposition was found to be the highest among all lipid types. Although the measured lipid levels are considered low for clinical deposition, they may impact other clinical outcomes such as comfort.
CONTACT LENS & ANTERIOR EYE
(2021)
Review
Ophthalmology
Alan Yee, Karen Walsh, Marc Schulze, Lyndon Jones
Summary: Reusable soft contact lenses continue to be popular among wearers, but the additional steps required for cleaning and disinfecting may lead to non-compliant behavior and potentially impact wearers' health. Educating patients, regulating the use of contact lens care solutions, and reevaluating global standards are key strategies to better support contact lens wearers.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
James S. Wolffsohn, Sonia Trave Huarte, Lyndon Jones, Jennifer P. Craig, Michael T. M. Wang
Summary: The survey revealed variations in the management of dry eye disease by eye care practitioners across continents and countries, with different prescription patterns for different severity levels and subtypes. Different management strategies are utilized for evaporative and aqueous deficient dry eye disease, indicating the need for tailored approaches based on individual patient needs.
Editorial Material
Ophthalmology
Jason J. Nichols, Lyndon W. Jones, Philip B. Morgan, Nathan Efron
Article
Ophthalmology
Hendrik Walther, Holly Lorentz, Miriam Heynen, Lise Kay, Lyndon W. Jones
Summary: This study examined the impact of incubation time, lipid concentration, and ATS replenishment on the uptake of phosphatidylcholine onto CH and SH contact lens materials. The results showed that all materials exhibited increasing PC deposition over time, with SH materials having higher uptake rates than CH materials. Increasing lipid concentration in the ATS resulted in increased PC binding onto the contact lens materials, while regular replenishment of the ATS showed different impacts on PC deposition for CH and SH materials.
OPTOMETRY AND VISION SCIENCE
(2021)
Article
Ophthalmology
Nathan Efron, Lyndon W. Jones, Phillip B. Morgan, Jason J. Nichols
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Parisa Mirzapour, David J. McCanna, Lyndon Jones
Summary: This study investigated the uptake of four pro-inflammatory cytokines onto six contemporary contact lens materials. It was found that both conventional hydrogels and two of the four silicone hydrogels tested showed some uptake of certain cytokines, while senofilcon A and somofilcon A did not exhibit uptake of any. Overall, the tested contact lens materials did not show significant uptake of IL-6 and had limited uptake of IL-1 beta, IL-8, or TNF-alpha.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Lyndon Jones, Alex Hui, Chau-Minh Phan, Michael L. Read, Dimitri Azar, John Buch, Joseph B. Ciolino, Shehzad A. Naroo, Brian Pall, Kathleen Romond, Padmaja Sankaridurg, Cristina M. Schnider, Louise Terry, Mark Willcox
Summary: Contact lenses in the future may have functions beyond correcting refractive errors, such as detecting systemic and ocular diseases, treating various eye conditions, correcting presbyopia, and controlling the development of myopia. Advancements in technology have led to the development of contact lenses as drug delivery devices and powered through nanotechnology. Challenges remain in integrating sensors into contact lenses and optimizing drug delivery to the ocular surface.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Eugene Appenteng Osae, Lyndon Jones, Jason J. Nichols
Summary: This review summarizes the evidence on how contact lens wear affects the morphology and secretion of the meibomian glands, with key factors such as duration, type, design, and material of the lenses influencing the extent of these changes.
Article
Microbiology
Christiane Lourenco Nogueira, Scott Joseph Boegel, Manish Shukla, William Ngo, Lyndon Jones, Marc G. Aucoin
Summary: This study investigated the impact of different contact lens care products on the infectiousness of two seasonal human coronaviruses. The results showed that oxidative disinfection systems exhibited significant virucidal activity, while non-oxidative systems showed minimal ability to inactivate the viruses.
Article
Ophthalmology
Jennifer P. Craig, Etty Bitton, Jaya Dantam, Lyndon Jones, William Ngo, Michael T. M. Wang
Summary: This study evaluated the short-term tolerability of five commercially available anti-demodectic eyelid cleansers, finding that different cleanser formulations may induce ocular discomfort, tear film instability, conjunctival hyperaemia, and ocular surface staining during application.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Instruments & Instrumentation
Ana F. F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Summary: This study aimed to evaluate the release profiles of two drug-loaded contact lenses (CLs) in a 3D in vitro eye blink model and compare them with in vivo profiles. The results showed that the release of both drugs was more sustained and lower in the 3D eye model compared to in vitro release in vials. The findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs, but further optimization is needed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Ophthalmology
Lyndon Jones, Nathan Efron, Kalika Bandamwar, Melissa Barnett, Deborah S. Jacobs, Isabelle Jalbert, Heiko Pult, Michelle K. Rhee, Heather Sheardown, Joseph P. Shovlin, Ulli Stahl, Adriana Stanila, Jacqueline Tan, Silvia Tavazzi, Omur O. Ucakhan, Mark D. P. Willcox, Laura E. Downie
Summary: The lifestyle choices of contact lens wearers can have negative impacts on eye health, such as poor adherence to care, sleeping in lenses, inappropriate purchases, lack of regular aftercare visits, wearing lenses while feeling unwell, wearing lenses too soon after surgery, and wearing lenses during risky behaviors. However, contact lenses can also provide therapeutic benefits. The COVID-19 pandemic introduced new challenges for contact lens wearers, including mask-associated dry eye, increased discomfort from digital device use, accidental exposure to hand sanitizers, and reduced lens usage.
Article
Ophthalmology
Miriam Heynen, Alan Ng, Elizabeth Martell, Lakshman N. Subbarannan, Lyndon Jones
Summary: The study found that there was no significant difference in the amount and activity of protein and lysozyme deposits on contact lenses between the peroxide-based system and the polyquaternium-1 and myristamidopropyl dimethylamine-containing system. However, the peroxide-based system showed a slightly lower total lysozyme deposition compared to the polyquaternium-1 and myristamidopropyl dimethylamine-containing system.
CLINICAL OPHTHALMOLOGY
(2021)