Journal
CURRENT EYE RESEARCH
Volume 35, Issue 2, Pages 99-107Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/02713680903428991
Keywords
Anti oxidants; Broccoli; Calpains; Oxidative stress; Selenite cataract
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Funding
- Kerala State Council for Science Technology and Environment (KSCSTE), Government of Kerala, India [(T) 17/R&D augmentation/04/KSCSTE]
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Purpose: To study the efficacy of Brassica oleracea var. italica (Broccoli) in the prevention of selenite induced biochemical changes and the incidence of cataractogenesis in vivo. Methods: Eight day old Sprague-Dawley rat pups were divided into four groups: I-Control; II-Sodium selenite (4 mg/kg body weight) administered; III-Sodium selenite + quercetin; and IV-Sodium selenite + flavonoid fraction of broccoli (FFB). Treatment groups III and IV received quercetin and FFB intraperitoneally from 8th to 15th day at a concentration (2.0 mg/kg body weight). The development of cataract was assessed and graded by slit-lamp examination. Some relevant biochemical parameters-such as activities of superoxide dismutase (SOD), catalase, Ca
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