Article
Biochemistry & Molecular Biology
Yuheng Shan, Yuying Cen, Yanjin Zhang, Ruishu Tan, Jiahua Zhao, Zhiyong Nie, Jiatang Zhang, Shengyuan Yu
Summary: The study demonstrated that P-glycoprotein inhibition can enhance the brain concentration of ceftriaxone (CFX) and increase its penetration across the blood-brain barrier (BBB). Cyclosporin A increased both the brain concentration and the ratio of unbound brain to unbound blood concentration of CFX in a dose-dependent manner, while verapamil only increased the brain concentration of CFX without affecting the penetration ratio across the BBB. Future studies with more selective P-gp inhibitors or knockout mouse models are needed to further investigate the impact of P-gp inhibition on CFX penetration across the BBB.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Negin Namazian Jam, Felix Gottloeber, Melanie Hempel, Yuliya Dzekhtsiarova, Stephan Behrens, Frank Sonntag, Jan Sradnick, Christian Hugo, Florian Schmieder
Summary: Despite their drawbacks, such as cost and predictive value, animal experiments remain the gold standard for pharmaceutical substance testing. Microphysiological systems offer a promising solution to the limitations of standard cell culture methods and the inability to mimic in vivo processes. This study examines the impact of pressure and flow on the transport of substances mediated by MDR1 across an artificial cell-based tubular barrier using a microphysiological system.
Article
Neurosciences
Liam M. Koehn, Katarzyna M. Dziegielewska, Mark D. Habgood, Yifan Huang, Norman R. Saunders
Summary: There are significant differences in the transfer of PGP substrate R123 between fetal and adult rats, with higher transfer rates observed in the newborn brain compared to adult brain. This suggests that the transfer rates of drugs may vary at different developmental stages and these patient-specific differences should be considered in toxicological testing and safety analysis.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Pharmacology & Pharmacy
Maria Carolina Andrade Guerra, Julia Teixeira Neto, Michele Gouvea Gomes, Lays Fernanda Nunes Dourado, Rodrigo Lambert Orefice, Luiz Guilherme Dias Heneine, Armando Silva-Cunha, Silvia Ligorio Fialho
Summary: Intravitreal injections are commonly used for drug delivery to the posterior segment of the eye, but their frequent administration leads to complications and poor adherence. Biodegradable nanofibers have the potential to regulate drug release and protect fragile bioactive drugs. Age-related macular degeneration is a leading cause of blindness and involves VEGF and inflammatory responses. In this study, we developed nanofiber-coated intravitreal implants for simultaneous delivery of dexamethasone and bevacizumab. The implants showed sustained drug release, reduction of vessels, and safety to the retina.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Amir Sadeghi, Jooseppi Puranen, Marika Ruponen, Annika Valtari, Astrid Subrizi, Veli-Pekka Ranta, Elisa Toropainen, Arto Urtti
Summary: Rats and rabbits were used to study intravitreal pharmacokinetics with non-invasive ocular fluorophotometry, showing differences in pharmacokinetic parameters between the two species which need to be considered in dose scaling and translation for drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mukharram M. Bikbov, Gyulli M. Kazakbaeva, Songhomitra Panda-Jonas, Dinar A. Khakimov, Leisan I. Gilemzianova, Liana A. Miniazeva, Azaliia M. Tuliakova, Albina A. Fakhretdinova, Renat A. Kazakbaev, Ildar F. Nuriev, Jost B. Jonas
Summary: This study evaluated the safety and tolerability of intraocular cetuximab in rabbits and found no toxic or destructive effects.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
N. M. Popova, A. V. Shchulkin, I. V. Chernykh, P. Yu. Mylnikov, E. N. Yakusheva
Summary: The study investigated the levels of P-glycoprotein (Pgp) in different organs of pregnant rabbits and its content and activity in the placental barrier at various stages of pregnancy. The results revealed an increase in Pgp content in the jejunum, liver, kidney, and cerebral cortex during different stages of pregnancy, as well as a decrease in Pgp content and activity in the placenta on later days of pregnancy. These findings suggest a role of Pgp in drug transport across the placenta during pregnancy.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Salma Jabeen, Sultan Alam, Luqman Ali Shah, Muhammad Zahoor, Muhammad Naveed Umar, Riaz Ullah
Summary: Treatment of textile effluent is important due to the presence of harmful and non-biodegradable dyes. Biosorption using hydrogel sorbents is a green and effective method. In this study, a novel hydrogel was synthesized and characterized. The hydrogel showed high adsorption capacity and swelling behavior, with excellent sorption potential at pH 7. Thermodynamic analysis indicated an exothermic nature of the adsorption process. These findings provide valuable insights into the characteristics and applications of the synthesized hydrogel.
Article
Food Science & Technology
Yajing Fang, Fuqiang Liang, Mengmeng Xia, Weiwei Cao, Siyi Pan, Ting Wu, Xiaoyun Xu
Summary: This study found that certain flavonoids can effectively reverse multidrug resistance mediated by P-glycoprotein (P-gp) by inhibiting its activity, with specific structural groups and substitutions playing a crucial role in their inhibitory effects. Additionally, flavonoids can impact P-gp ATPase activity and expression levels, thereby influencing its drug transport activity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lu Jin, Xiumin Li, Xu Chen, Xinghao Chen, Ye Liu, Haonan Xu, Qiao Wang, Zhan Tang
Summary: This study found that Puerarin in the PVP-K30 and gellan gum formulation significantly increased the drug concentration in the eye, indicating good prospects for clinical application.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Xinfei Zhang, Yuan Zhang, Ziwei Wang, Nan Zhang, Xiaobo Jia
Summary: Efficient and stable photocatalysts play a critical role in removing organic waste from water. In this study, a series of Ag2O/phosphors-doped g-C3N4 (AgO/PCN) composites with p-n heterojunctions were prepared and demonstrated excellent photocatalytic degradation abilities for Rhodamine 6G (Rh 6G) and Levofloxacin (LVFX) under visible light irradiation.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Engineering, Environmental
Lijie Zhao, Shuo Wang, Jianxin Wang, Haixia Yu, Chunyan Zhao, Lu Meng
Summary: In this study, a [P(W3O10)(4)](3-)g-C3N4 composite catalyst was prepared and showed efficient photocatalytic removal of Rhodamine B (RhB) organic wastewater. The [P(W3O10)(4)]-g-C3N4 catalyst exhibited higher degradation efficiency compared to g-C3N4, and the corresponding active species were proposed. Additionally, the catalyst demonstrated unique dye detection properties.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Medicinal
Rong Yang, Zhenxing Chen, Fuda Xie, Mingxiang Xie, Na Liu, Ziren Su, Jiangyong Gu, Ruizhi Zhao
Summary: The study investigated the inhibitory effect of (+)-borneol and (-)-borneol on P-glycoprotein (Pgp) in reversing mitoxantrone (MTO) resistance. The results showed that both borneol enantiomers could enhance the efficacy of MTO in cancer cells by reducing the protein expression of Pgp and interfering with the binding affinity between MTO and Pgp in the drug-binding pocket. Using molecular docking and dynamics simulations, the study identified key amino acid residues responsible for borneols' ability to reverse MTO resistance through noncompetitive inhibition.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Energy & Fuels
Seyyed Alireza Mousavi, Bahram Kamarehie, Ali Almasi, Mohammad Darvishmotevalli, Mehdi Salari, Maryam Moradnia, Faramarz Azimi, Mansour Ghaderpoori, Zhaleh Neyazi, Mohammad Amin Karami
Summary: In this study, activated carbon prepared from stalk corn was proven to be an effective and economical adsorbent for removing Rhodamine B dye from aqueous solutions. The optimal conditions for adsorption were found to be a pH of 3 and an adsorbent dosage of 2.5 g L-1, with the Freundlich isotherm model fitting well with the experimental data. The maximum adsorption capacity achieved was 5.6 mg g(-1), and the adsorption of Rhodamine B followed pseudo-second-order kinetics.
BIOMASS CONVERSION AND BIOREFINERY
(2021)
Article
Biology
Shane Denecke, Hang Ngoc Bao Luong, Venetia Koidou, Maria Kalogeridi, Rafaella Socratous, Steven Howe, Kathrin Vogelsang, Ralf Nauen, Philip Batterham, Sven Geibel, John Vontas
Summary: This study provides a comprehensive characterization of pesticide transporters in the model insect Drosophila melanogaster. It identifies a novel ABC drug transporter and highlights the most impactful ABC in terms of chemoprotection. The study also reveals the potential roles of P-glycoproteins with different subcellular localizations in pesticide toxicology. Furthermore, the establishment of a system for in vivo characterization of drug transporters in non-model insects using transgenic Drosophila lines expressing P-glycoprotein from Anopheles gambiae is significant.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Ophthalmology
Vignesh Menta, Shweta Agarwal, Ujjalkumar Subhash Das, Laxmi Moksha, Gurumurthy Srividya, Amrutha M. Anandan, Bhaskar Srinivasan, Geetha Iyer, Thirumurthy Velpandian, Narayanasamy Angayarkanni
Summary: This study found altered sphingolipid metabolism in the ocular surface of patients with vernal keratoconjunctivitis (VKC), resulting in decreased levels of specific metabolites in tears. The study also showed increased gene expression of relevant receptors and proteins in mast cells treated with IgE. This novel finding opens up new targets for intervention in VKC.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Abdul W. Moothedath, Jagdish P. Meena, Aditya K. Gupta, Thirumurthy Velpandian, Ravindra M. Pandey, Rachna Seth
Summary: This study evaluated the safety and efficacy of olanzapine in children receiving highly emetogenic chemotherapy. The results showed that olanzapine significantly improved complete control of vomiting in the delayed phase and reduced the need for rescue medications.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Chemistry, Analytical
Lakshminarayanan Gowtham, Das Ujjalkumar, Laxmi Moksha, Tapas Kumar Roy, Nabanita Halder, Thirumurthy Velpandian
Summary: A rapid method for analyzing 4-hydroxy isoleucine in human plasma has been developed, and the levels of 4-hydroxy isoleucine in human plasma and commercial fenugreek formulations were determined. The method shows good linearity, accuracy, and precision, making it suitable for clinical pharmacokinetics studies of 4-hydroxy isoleucine in the human population.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Rheumatology
Umang Bhardwaj, Narendra K. Bagri, Rakesh Lodha, Sushil K. Kabra, Thirumurthy Velpandian, Ravindra M. Pandey
Summary: This study aimed to evaluate the efficacy and safety of pulse dexamethasone therapy in children with treatment-naive non-systemic JIA. The results showed that the addition of pulse dexamethasone to standard treatment may not have any advantage in improving ACR-Pedi 70 scores at medium-term follow-up.
Article
Acoustics
Sindhuja Kandasamy, Sahil Agrawal, Neelam Pushker, Rachna Meel, Mandeep S. Bajaj, Velpandian Thirumurthy, Viveka P. Jyotsna
Summary: This study used ultrasound biomicroscopy (UBM) to measure the thickness of levator palpebra superioris-Muller's muscle complex (LMC) in patients with thyroid-related upper eyelid retraction (UER) and correlated it with the clinical response to botulinum toxin A (BTA) injection. The results showed that UER patients had significantly thicker LMC compared to normal controls. Further studies are needed to explore the correlation between UBM features and response to BTA injection.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Letter
Oncology
Layne J. Silver, Pooja Desai, Sareen Shah, Julie Krystal, Matthew Taylor, Kristina Murphy
PEDIATRIC BLOOD & CANCER
(2023)
Review
Respiratory System
Fajri Gafar, Roeland E. Wasmann, Helen M. McIlleron, Rob E. Aarnoutse, H. Simon Schaaf, Ben J. Marais, Dipti Agarwal, Sampson Antwi, Nguyen D. Bang, Adrie Bekker, David J. Bell, Chishala Chabala, Louise Choo, Geraint R. Davies, Jeremy N. Day, Rajeshwar Dayal, Paolo Denti, Peter R. Donald, Ephrem Engidawork, Anthony J. Garcia-Prats, Diana Gibb, Stephen M. Graham, Anneke C. Hesseling, Scott K. Heysell, Misgana I. Idris, Sushil K. Kabra, Aarti Kinikar, Agibothu K. Hemanth Kumar, Awewura Kwara, Rakesh Lodha, Cecile Magis-Escurra, Nilza Martinez, Binu S. Mathew, Vidya Mave, Estomih Mduma, Rachel Mlotha-Mitole, Stellah G. Mpagama, Aparna Mukherjee, Heda M. Nataprawira, Charles A. Peloquin, Thomas Pouplin, Geetha Ramachandran, Jaya Ranjalkar, Vandana Roy, Rovina Ruslami, Ira Shah, Yatish Singh, Marieke G. G. Sturkenboom, Elin M. Svensson, Soumya Swaminathan, Urmila Thatte, Stephanie Thee, Tania A. Thomas, Tjokosela Tikiso, Daan J. Touw, Anna Turkova, Thirumurthy Velpandian, Lilly M. Verhagen, Jana L. Winckler, Hongmei Yang, Vycke Yunivita, Katja Taxis, Jasper Stevens, Jan-Willem C. Alffenaar
Summary: This study aims to investigate the pharmacokinetics of first-line anti-TB drugs in children and adolescents globally. The results show that younger age and HIV-positive status are associated with lower AUC(0-24) for all first-line anti-TB drugs, while severe malnutrition is associated with lower AUC(0-24) for isoniazid and pyrazinamide. The determinants of Cmax are generally similar to those of AUC(0-24).
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Ophthalmology
Vishal Kumar, Pooja Kumari, Neiwete Lomi, Murugesan Vanathi, Noopur Gupta, Radhika Tandon, T. Velpandian, Nishat Ahmed, Gita Satpathy
Summary: This study evaluated the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungal keratitis. Patients with confirmed fungal keratitis were administered topical L-AMB and randomized into three groups treated with different formulations. L-AMB in gel form was found to be an effective antifungal agent that promoted the healing of fungal ulcers with less vascularization and better tolerance.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cell Biology
Muneeb Faiq, Trina Sengupta, Madhu Nath, Thirumurthy Velpandian, Daman Saluja, Rima Dada, Tanuj Dada, Kevin Chan
Summary: This study found that central insulin resistance leads to increased intraocular pressure, dysfunction in trabecular meshwork and ciliary body, decreased cell density and insulin receptor expression in the retina, peripapillary atrophy and vascular dysregulation. These changes are accompanied by dysregulation of genes involved in inflammation, glial activation and apoptosis, and affect multiple pathways relevant to neurodegeneration.
NEURAL REGENERATION RESEARCH
(2023)
Article
Ophthalmology
Jeewan Singh Titiyal, Ananya Goswami, Manpreet Kaur, Namrata Sharma, Prafulla Kumar Maharana, T. Velpandian, R. M. Pandey
Summary: The purpose of this study was to compare the effect of topical cyclosporine-A 0.05% and chloroquine phosphate 0.03% as adjuncts to standard therapy in maintaining ocular surface stability after LASIK. The results showed that both CsA and CHQ groups had significantly better OSDI score, MMP-9 levels, tear osmolarity, TBUT, and Schirmer score at 6 months compared to the control group (p < 0.001). CsA group had comparable MMP-9 levels to baseline and lower ocular irritative effects compared to the CHQ group. Both CsA and CHQ are effective adjuncts in maintaining ocular surface stability after refractive surgery.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Dewang Angmo, Karthikeyan Mahalingam, Lakshminarayanan Gowtham, Priyaadharshini Elancheliyan, Thirumurthy Velpandian, Ramanjit Sihota, Tanuj Dada
Summary: The study aims to evaluate the systemic absorption of mitomycin C (MMC) during trabeculectomy and its potential systemic toxicity. The results showed that MMC was not detected in the plasma samples of the participants, indicating negligible systemic absorption or plasma concentration below 1.56 ng/ml (1000 times lower than the concentration where systemic toxicity was not observed).
CURRENT EYE RESEARCH
(2023)
Article
Biology
Pradip Nirbhavane, Laxmi Moksha, Gajanand Sharma, Thirumurthy Velpandian, Bhupinder Singh, O. P. Katare
Summary: This study evaluated a novel nano-lipoidal eye drop formulation of triamcinolone acetonide (TA) for the topical treatment of uveitis. The developed triamcinolone acetonide-loaded nanostructured lipid carriers (cTA-NLC) showed sustained release and enhanced efficacy in vitro. In vivo efficacy was tested on Wistar rats and a pharmacokinetic study was conducted in rabbits. The results demonstrated that the cTA-NLC formulation effectively managed uveitis with minimal signs of inflammation.
Article
Infectious Diseases
Benu Dhawan, Deepak Juyal, Jyoti Rawre, Maitrayee Narayan, Thirumurthy Velpandian, Vishnubhatla Sreenivas, Bhavuk Garg, Rajesh Malhotra
Summary: This study aimed to determine the effectiveness of a bundled intervention in reducing prosthesis-related infections (PRIs) and surgical site infections (SSIs). A prospective, interventional randomized controlled trial was conducted over three years, and the results showed that the bundled intervention approach could effectively reduce infection rates.
SURGICAL INFECTIONS
(2023)
Article
Ophthalmology
Taraprasad Das, Joveeta Joseph, Saumya Jakati, Savitri Sharma, Thirumurthy Velpandian, Srikant K. Padhy, Vipin A. Das, Sisinthy Shivaji, Sameera Nayak, Umesh C. Behera, Dilip K. Mishra, Jaishree Gandhi, Vivek P. Dave, Avinash Pathengay
Summary: Fungal endophthalmitis is a potentially blinding condition, more commonly reported in Asia and specifically India. It has a lower incidence compared to bacterial endophthalmitis but is more challenging to treat. The current mainstays of treatment include vitrectomy, intravitreal antifungal agents, and systemic therapy. However, difficulties in clinical diagnosis, delayed microbiological culture, and limited options of antifungal drugs make the treatment more difficult and less rewarding.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Aafreen Bari, Rohan Chawla, Deepanshi Mishra, Ujjwalkumar Das, Nasiq Hasan, Gita Satpathy, T. Velpandian, Shorya Azad, Pradeep Venkatesh, Rajpal Vohra, Atul Kumar
Summary: A real-life comparison study conducted at a tertiary care center in India found that the choice of antibiotics did not affect the rate of vitrectomy and final vision. Ceftazidime and vancomycin can still be used as first-line intravitreal antibiotics due to their comparable microbial sensitivity profile and adequate ocular bioavailability.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)