Article
Biochemistry & Molecular Biology
Dongjoon Kim, Marcela Votruba, Sayon Roy
Summary: Reduced level of Opa1 promotes apoptosis and retinal vascular lesions associated with diabetic retinopathy. Downregulation of Opa1 expression contributes to the development of retinal cell death and capillary damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anatomy & Morphology
Zhiwei Xu, Shi Bai, Haijian Wu, Marong Fang
Summary: This study found that diabetic mice had elevated retinal RBP4 levels, and high levels of retinal RBP4 can induce retinal neurodegeneration through microglia. Inhibition of neuroinflammation or reduction of retinal RBP4 level may be a potential therapeutic strategy to prevent diabetic retinal neurodegeneration.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Cell Biology
Dongjoon Kim, Hiromi Sesaki, Sayon Roy
Summary: The study found that reducing Drp1 levels can decrease diabetes-induced retinal vascular lesions, reduce the number of acellular capillaries and pericyte loss, and is associated with an increase in the expression of apoptosis-related genes.
Review
Physiology
Katharine L. Bunch, Ammar A. Abdelrahman, Ruth B. Caldwell, R. William Caldwell
Summary: Diabetic retinopathy (DR) and diabetic macular edema (DME) are complications of diabetes that can cause vision loss and reduced quality of life. Current treatments for advanced DR and DME are invasive, expensive, and can have adverse side-effects. Therefore, there is a need for more effective, affordable, and accessible therapies that can target early stage disease. Novel therapies under investigation include erythropoietin-derived peptides, inducers of antioxidant gene expression, activators of nitric oxide/cyclic GMP signaling pathways, and manipulation of arginase activity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Kyoung In Jung, Jeong-Sun Han, Chan Kee Park
Summary: Nicotinamide plays a neuroprotective role in diabetic retinal neurodegeneration by reducing oxidative DNA damage and supporting DNA repair.
Article
Endocrinology & Metabolism
Jianchen Hao, Jiantong Du, Xiaopeng Gu, Yadi Zhang, Liu Yang, Shijie Zhang
Summary: This study found that there is a correlation between intraretinal blood flow perfusion and nerve changes in diabetic patients without diabetic retinopathy. Optical coherence tomography (OCT) and OCT angiography were performed on 86 diabetic patients, and it was found that the thickness of the ganglion cell-inner plexiform layer (GCIPL) in the macular area of affected eyes was lower compared to the control group. The study also found a positive correlation between the mean vessel length density and GCIPL thickness in the macular area, but no correlation between blood flow perfusion parameters and retinal nerve fibre layer (RNFL) thickness.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Huan-ran Zhou, Xue-fei Ma, Wen-jian Lin, Ming Hao, Xin-yang Yu, Hong-xue Li, Cheng-ye Xu, Hong-yu Kuang
Summary: In high glucose conditions, GLP-1 analog can alleviate damage to retinal ganglion cells (RGCs) and prevent mitophagy, demonstrating a neuroprotective effect. This provides new insights for preventing diabetic retinopathy (DR) by expanding the multi-organ benefits of GLP-1 analogs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Wen Mei, Biao Zhu, Yi Shu, Yanhua Liang, Mei Lin, Mingjuan He, Haizhao Luo, Jingwen Ye
Summary: The study demonstrated that GDF11 treatment improved diabetes-induced retinal dysfunction in mice by protecting against cell death, capillary degeneration, inflammation, and inhibiting blood-retinal barrier breakdown. The mechanism of protection involves TGF-β/Smad2, PI3K-Akt-FoxO1 activation, and NF-κB pathway inhibition.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Warren W. Pan, Thomas W. Gardner, Jennifer L. Harder
Summary: DRD remains a common cause of vision loss in working-age adults, with limited progress on new therapies due to the complexity of the human eye. Utilizing systems biology approaches that have been successful in DKD research may help clarify the molecular basis and progression of DRD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Wangyi Fang, Xiaojing Huang, Kaicheng Wu, Yuan Zong, Jian Yu, Huan Xu, Jiemei Shi, Jiaojiao Wei, Xujiao Zhou, Chunhui Jiang
Summary: The study found that berberine has potential in protecting injured retinal ganglion cells in diabetic retinopathy. Its key protective effect may involve the regulation of retinal ganglion cell apoptosis through the GABA-alpha receptor/protein kinase C-alpha pathway.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yuxin Hu, Qian Xu, Hongxue Li, Ziyu Meng, Ming Hao, Xuefei Ma, Wenjian Lin, Hongyu Kuang
Summary: The study revealed that dapagliflozin can slow the progression of diabetic retinopathy by reducing apoptosis of retinal cells, and alleviate HRMECs apoptosis induced by high glucose through the ERK/1/2/cPLA2/AA/ROS pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu, Huizhuo Xu
Summary: The study found that DNMT1-mediated PPAR alpha methylation promotes apoptosis and ROS levels in HRCPs, exacerbating retinal tissue damage in DR mice.
BIOLOGICAL RESEARCH
(2021)
Article
Oncology
Viviane Aline Oliveira Silva, Nayara Delgado Andre, Thais Amaral Sousa, Vani Maria Alves, Isis Do Carmo Kettelhut, Fernando Luiz De Lucca
Summary: PKR can be localized in the nuclei of retinal neurons in the early stages of diabetic retinopathy, with its activity potentially demonstrated through the expression of p-eIF2-alpha in the nucleus. However, apoptotic cells were not detected in the retina during this early stage of DR. The study proposes a model involving mtRNA and Alu RNA in the suppression of retinal neuron apoptosis by PKR.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, Research & Experimental
Bing Xue, Yu Wang
Summary: This study suggests that naringenin has therapeutic potential in preventing retinal endothelial cell injury induced by high glucose. It effectively inhibits cell apoptosis and reduces intracellular oxidative stress through the upregulation of GTPCH1/eNOS signaling.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Dan Liang, Yulin Qi, Lu Liu, Zhaoxia Chen, Shiyun Tang, Jianyuan Tang, Nianzhi Chen
Summary: This study aimed to investigate the pharmacological effects and mechanisms of Jin-Gui-Shen-Qi Wan (JGSQ) in improving diabetic retinopathy (DR). The results showed that JGSQ had a significant effect on protecting retinal ganglion cells from apoptosis, possibly through modulating the Akt/HIF-1 alpha pathway.
Article
Chemistry, Medicinal
Aya Chubachi, Akiko Miki, Mayuka Hayashida, Mari Sakamoto, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
Summary: This study found that low-contrast visual acuity is significantly affected after reduced-fluence photodynamic therapy in patients with resolved central serous chorioretinopathy and good baseline visual acuity. Affected eyes had significantly worse low-contrast visual acuity compared to fellow eyes, and symptom duration may play a role in affecting low-contrast visual acuity post-treatment.
Article
Ophthalmology
Mina Okuda, Sotaro Mori, Fumio Takano, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
Summary: This study found that the long-term use of multiple glaucoma drugs can adversely affect the success of mu TLO at least one year after the surgery.
ACTA OPHTHALMOLOGICA
(2022)
Article
Medicine, General & Internal
Kaori Ueda, Takuji Kurimoto, Fumio Takano, Yusuke Murai, Sotaro Mori, Mari Sakamoto, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura
Summary: The study aims to evaluate the efficacy and safety of SES in LHON patients carrying the G11778A mutation through a more frequent stimulation protocol. It is a single-arm, open-labelled, non-randomised clinical study lasting for 12 weeks, with primary outcome measure being best-corrected visual acuity (BCVA) and secondary outcome measures including visual field sensitivity test, among others.
Article
Ophthalmology
Daiki Sakai, Sakiko Demoto, Yukako Iwai, Yasuhiko Hirami, Makoto Nakamura, Yasuo Kurimoto
Summary: This study aimed to compare the accuracy of intraoperative aberrometry (IA) in predicting postoperative refraction between eyes with emmetropia and myopia targets. The results showed that IA was the most accurate method for predicting postoperative refraction in eyes with emmetropia target, while the Barrett Universal II formula was found to be the most accurate for eyes with myopia target.
CLINICAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Fumio Takano, Sotaro Mori, Mina Okuda, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
Summary: The use of antithrombotic drugs during glaucoma surgery does not affect the success rates of the procedures, but it increases the risk of early postoperative hemorrhagic complications.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Noriyuki Sotani, Sentaro Kusuhara, Wataru Matsumiya, Mina Okuda, Sotaro Mori, Rei Sotani, Kyung Woo Kim, Ryuto Nishisho, Makoto Nakamura
Summary: Microhook trabeculotomy (mu LOT) is an effective and safe option for the treatment of uveitic glaucoma. The surgical success rate is 67%, with significant improvements in intraocular pressure and glaucoma drug score.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Fumio Takano, Kaori Ueda, Daniel A. Godefrooij, Akiko Yamagami, Hiroto Ishikawa, Hideki Chuman, Hitoshi Ishikawa, Yasuhiro Ikeda, Taiji Sakamoto, Makoto Nakamura
Summary: Accurately estimating the incidence and prevalence of LHON patients is important due to the low incidence rate.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Ophthalmology
Yukako Iwane, Hisanori Imai, Hiroko Yamada, Yasuyuki Sotani, Mariko Oishi, Makoto Nakamura
Summary: The study reported good postoperative visual acuity after surgical removal of hard exudates (HEs) through intentional macular hole (iMH). This method was successfully used to treat pathological lesions secondary to diabetic maculopathy (DM) in 3 cases.
CASE REPORTS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Wataru Matsumiya, Sentaro Kusuhara, Noriyuki Sotani, Kyung Woo Kim, Ryuto Nishisho, Rei Sotani, Hisanori Imai, Akihito Uji, Makoto Nakamura
Summary: Spectral domain optical coherence tomography (SD-OCT) was used to evaluate the characteristics of posterior vitreous cells in patients with uveitis. The study found that patients with infectious uveitis (IFU) had a higher number and density of vitreous particles, as well as larger particle size, compared to noninfectious granulomatous uveitis (NIGU) and noninfectious nongranulomatous uveitis (NINGU) patients.
CLINICAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Mina Okuda, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura
Summary: This study aimed to evaluate the effect of ripasudil use on the outcome of mu TLO. The results showed that patients who took ripasudil had a higher success rate at 1 year, indicating a positive impact of ripasudil on mu TLO.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Akari Kimura, Hisanori Imai, Yukako Iwane, Maya Kishimoto, Yasuyuki Sotani, Hiroko Yamada, Wataru Matsumiya, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
Summary: This new technique can effectively remove sub-internal limiting membrane hemorrhage without peeling the internal limiting membrane, resulting in improved visual acuity and prevention of full-thickness macular hole formation in patients with submacular hemorrhage caused by retinal arterial macroaneurysm rupture.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Makoto Nakamura, Mari Sakamoto, Kaori Ueda, Mina Okuda, Fumio Takano, Yuko Yamada-Nakanishi
Summary: This study evaluated the correlation between the asymmetry of peripapillary capillary perfusion density (CPD) and the severity of relative afferent pupillary defect (RAPD) in patients with asymmetric glaucomatous optic neuropathy (GON). A novel hand-held pupillometer, Hitomiru, was used to assess RAPD. The study found that CPD asymmetry may better correlate with RAPD than cpRNFLT and GCL/IPLT asymmetry.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Mina Okuda-Arai, Sotaro Mori, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura
Summary: The impact of preoperative glaucoma medications on the outcomes of Schlemm's canal surgery was investigated in this study. The results showed that the use of beta-blockers and oral CAI before surgery increased the risk of surgical failure.
ACTA OPHTHALMOLOGICA
(2023)
Article
Medicine, General & Internal
Maya Kishi, Akiko Miki, Aya Kamimura, Mina Okuda, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
Summary: This retrospective study evaluated the functional and anatomical effects of switching to faricimab for neovascular age-related macular degeneration (nAMD) patients who were refractory to intravitreal aflibercept. The results showed that after switching, the patients experienced a significant decrease in central retinal thickness (CRT), an extended injection interval, and a decrease in the presence of intraretinal fluid and subretinal fluid. However, best-corrected visual acuity (BCVA) and central choroidal thickness (CCT) did not change significantly. The study suggests that switching to faricimab could be an additional treatment option for nAMD patients who are refractory to aflibercept.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sentaro Kusuhara, Maya Kishimoto-Kishi, Wataru Matsumiya, Akiko Miki, Hisanori Imai, Makoto Nakamura
Summary: This study aimed to evaluate the short-term outcomes of intravitreal injection of faricimab (IVF) for the treatment of diabetic macular edema (DME) in clinical practice. The results showed that IVF can preserve visual acuity and improve macular thickness without serious safety concerns.
MEDICINA-LITHUANIA
(2023)
