Review
Cell Biology
Stepan Gambaryan
Summary: Circulating blood platelets are regulated by stimulatory and inhibitory factors, and maintaining a balance between these processes is crucial for normal platelet and vascular function. The NO/cGMP/PKG signaling pathway plays a significant role in platelet inhibition, but its regulation is still not well understood.
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Plant Sciences
Rui Chen, Ting Chen, Tianqi Wang, Xiangdong Dai, Shuying Zhang, Di Jiang, Ke Meng, Yanyan Wang, Tong Geng, Jinpeng Xu, Kun Zhou, Yi Wang
Summary: TMYX improves myocardial NR by upregulating NO activity and relaxing coronary microvessels through the cAMP/PKA and NO/cGMP signaling pathways, demonstrating cardio-protective effects against ischemia and reperfusion.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Ming Lu, Yanpeng Wang, Yuanye Jiang, Cuiping Zhang, Hongping Wang, Wenjun Sha, Lin Chen, Tao Lei, Limei Liu
Summary: The aim of this study was to investigate the effect of berberine (BBR) on gluconeogenesis. The effects of BBR were examined in rat primary hepatocytes and confirmed in vivo in spontaneous diabetic rats. The results showed that BBR inhibited gluconeogenesis by downregulating G6Pase and PEPCK via inhibition of CREB phosphorylation. Moreover, BBR activated the NO/cGMP/PKG signaling pathway by enhancing NO and cGMP concentrations through activating the AKT1/MAPK axis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Multidisciplinary Sciences
Se-Min Kim, Tony Yuen, Jameel Iqbal, Mishaela R. Rubin, Mone Zaidi
Summary: The NO-cGMP-PKG pathway is crucial for skeletal homeostasis, but long-term use of NO is limited by off-target effects. Inhibiting cGMP-specific phosphodiesterase to promote the anabolic signal offers a potential treatment for osteoporosis with PDE5A inhibitors. Further research is needed to investigate the specific effects of PDE5A inhibition on bone cells and the pathophysiological changes in skeletal PDE5A expression.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zaidatul Akmal Othman, Zaida Zakaria, Joseph Bagi Suleiman, Victor Udo Nna, Aminah Che Romli, Wan Syaheedah Wan Ghazali, Mahaneem Mohamed
Summary: This study demonstrates that bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity in obese rats by improving the eNOS/NO/cGMP-signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Marta Toral, Andrea de la Fuente-Alonso, Miguel R. Campanero, Juan Miguel Redondo
Summary: NO signaling dysregulation plays a key role in the pathogenesis of thoracic aortic aneurysm, particularly in Marfan syndrome. Current medical treatments are limited to surgical repair, highlighting the need for alternative therapies. Emerging research identifies iNOS, sGC, and PRKG1 as potential therapeutic targets for intervention.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Andrea de la Fuente-Alonso, Marta Toral, Alvaro Alfayate, Maria Jesus Ruiz-Rodriguez, Elena Bonzon-Kulichenko, Gisela Teixido-Tura, Sara Martinez-Martinez, Maria Jose Mendez-Olivares, Dolores Lopez-Maderuelo, Ileana Gonzalez-Valdes, Eusebio Garcia-Izquierdo, Susana Mingo, Carlos E. Martin, Laura Muino-Mosquera, Julie De Backer, J. Francisco Nistal, Alberto Forteza, Arturo Evangelista, Jesus Vazquez, Miguel R. Campanero, Juan Miguel Redondo
Summary: The NO pathway is found to be overactivated in Marfan Syndrome patients and mice, with inhibition of guanylate cyclase and cGMP-dependent protein kinase shown to reverse Marfan-like aortopathy in mice.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Liqian Chen, Xinghong Zhou, Yijian Deng, Ying Yang, Xiaohu Chen, Qinghong Chen, Yanyan Liu, Xiuqiong Fu, Hiu Yee Kwan, Yanting You, Wen Jin, Xiaoshan Zhao
Summary: This study aimed to confirm the protective effects of ZWD on cardiac hypertrophy and explore the underlying mechanisms. The results showed that ZWD reduces oxidative stress and inflammation and exerts cardioprotective effects by activating the sGC-cGMP-PKG signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Oncology
Angelina T. Regua, Mariana Najjar, Hui-Wen Lo
Summary: Aberrant activation of RET receptor tyrosine kinase is associated with various types of cancer and poor prognosis. Inhibitors targeting RET kinase activity have shown promising preclinical and clinical efficacy in treating metastatic cancers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Panagiotis F. Christopoulos, Torleif T. Gjolberg, Stig Kruger, Guttorm Haraldsen, Jan Terje Andersen, Eirik Sundlisaeter
Summary: The Notch signaling pathway plays a supporting role in various inflammation-driven diseases, but targeting this pathway for treatment has proven challenging due to its broad involvement in regenerative and homeostatic processes. Efforts to intervene with the Notch pathway by targeting Notch ligands and/or receptors through distinct therapeutic strategies, including antibody designs, are ongoing. Lessons learned from Notch targeting in cancer treatment may help guide the development of therapeutic strategies for chronic inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yunjia Song, Zihang Xu, Qing Zhong, Rong Zhang, Xutao Sun, Guozhen Chen
Summary: This review provides a comprehensive examination of the function and potential mechanism of S-sulfhydration and S-sulfenylation in the cardiovascular system, highlighting that proteins undergoing these modifications may serve as promising targets for therapeutic intervention and drug development.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Marjan Talebi, Dalia M. Kopustinskiene, Saeed Samarghandian, Jurga Bernatoniene
Summary: This review highlights the crucial role of nitric oxide (NO) in cellular aging processes, discussing its mechanisms and effects in various systems and organs, as well as the decline in NO levels and bioavailability associated with aging. Additionally, potential therapeutic agents affecting NO signaling mechanisms in aging are also discussed.
Review
Immunology
Yan Yan, Yuanwang Qiu, Chantsalmaa Davgadorj, Chunfu Zheng
Summary: Numerous signaling pathway agonists or inhibitors have been found to reduce HBV replication, and some of them have been used in clinical trials. A combined strategy including antiviral therapy and immunomodulation is crucial for effective control of HBV infection. These findings assist in the design of novel agents to prevent HBV replication or carcinogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Fleischmann, Manuela Harloff, Sara Maslanka Figueroa, Jens Schlossmann, Achim Goepferich
Summary: Encapsulating cinaciguat into virus-mimetic nanoparticles can effectively target renal mesangial cells, increasing drug accumulation and enhancing efficacy. NP-assisted drug delivery not only improves sGC stabilization and activation, but also significantly suppresses the non-canonical TGF-beta signaling pathway, reducing fibrotic remodeling. This system holds promise for a more refined therapy of DN and related kidney pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
