Article
Pharmacology & Pharmacy
Janaina de Alcantara Lemos, Daniel Cristian Ferreira Soares, Nara Caroline Pereira, Livia Santos Gomides, Juliana de Oliveira Silva, Gisele Eva Bruch, Geovanni Dantas Cassali, Laleh Alisaraie, Ricardo Jose Alves, Adelina Pinheiro Santos, Andre Luis Branco de Barros
Summary: Multiwalled carbon nanotubes (MWCNTs) have shown promise in biomedical studies due to their unique properties, but their compatibility and dispersibility remain challenges. This study introduces polyethylene glycol chains coated MWCNTs (PEG-MWCNTs) that exhibited prolonged circulation time and high tumor uptake rates in mice models. Toxicological data on healthy animals showed no significant toxicity, suggesting PEG-MWCNTs as potential candidates for oncologic applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Aziz B. Mirkasymov, Ivan Zelepukin, Ilya N. Ivanov, Iaroslav B. Belyaev, Dzhuliia Sh Dzhalilova, Daria B. Trushina, Alexey Yaremenko, Vsevolod Yu Ivanov, Maxim P. Nikitin, Petr Nikitin, Andrei Zvyagin, Sergey M. Deyev
Summary: In this study, a new method using ferrihydrite particles to block the mononuclear phagocyte system (MPS) and improve nanomedicine delivery efficacy was proposed. The surface coating of ferrihydrite particles with carboxymethyl-dextran significantly prolonged the circulation time of magnetic nanoparticles in the bloodstream and increased tumor targeted delivery. Furthermore, high doses of ferrihydrite showed low toxicity, with rapid recovery of toxicological parameters after 3 days.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Biomaterials
Maki Nakamura, Katsuya Ueda, Yumiko Yamamoto, Kaoru Aoki, Minfang Zhang, Naoto Saito, Masako Yudasaka
Summary: This study developed a new nanocomposite for the treatment of bone metastasis by inhibiting the destruction of bones. The nanocomposite, composed of BPs loaded onto OxCNHs using CaPs as mediators, showed promising potential for localized treatment of bone destruction caused by metastasis.
BIOMATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Van Phuc Nguyen, Wei Qian, Yanxiu Li, Bing Liu, Michael Aaberg, Jessica Henry, Wei Zhang, Xueding Wang, Yannis M. Paulus
Summary: This study presents a new type of ultrapure chain-like gold nanoparticle (CGNP) clusters with excellent biocompatibility and photostability. Upon validation in living rabbits after conjugation with RGD peptides, they demonstrate a 17-fold increase in PAM signal and a 176% increase in OCT signal, showing their potential for in vivo imaging.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Bassma H. Elwakil, M. Toderas, Mostafa El-Khatib
Summary: Nano metals have received significant attention recently. This study focuses on the preparation of different forms of copper oxide (CuO) using the Arc discharge process. The results show that CuO nano wires (CuO-NWs) exhibit potent antibacterial activity against multi-drug resistant Acinetobacter baumannii strains.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Review
Chemistry, Multidisciplinary
Suchi Smita Gupta, Krishna P. Singh, Shailendra Gupta, Maria Dusinska, Qamar Rahman
Summary: This review compares CNTs and asbestos fibers in terms of their structural characteristics, bio-persistence, surface to volume ratio, and ability to adsorb toxins/pollutants. The study also examines the mechanisms underlying the toxicity caused by certain types of CNTs and asbestos fibers, using altered gene expression data. The results suggest that certain types of CNTs do indeed mimic asbestos fibers in terms of associated toxicity.
Article
Environmental Sciences
Ifeoluwa O. Awogbindin, Ikenna C. Maduako, Isaac A. Adedara, Solomon E. Owumi, Akinola O. Ajeleti, Olatunde Owoeye, Anita K. Patlolla, Paul B. Tchounwou, Ebenezer O. Farombi
Summary: Studies have shown that exposure to multiwalled carbon nanotubes (MWCNTs) can impair liver and kidney function in rats through oxidative stress and inflammation, while treatment with kolaviron (KV) can mitigate these effects by its anti-inflammatory and antioxidant properties.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Adam Truskewycz, Hong Yin, Nils Halberg, Daniel T. H. Lai, Andrew S. Ball, Vi Khanh Truong, Agata Marta Rybicka, Ivan Cole
Summary: This article discusses the therapeutic potential of carbon quantum dots (CQDs) in biomedical applications. CQDs have shown biocompatibility and have been used for drug solubility, targeting, and facilitating drug delivery. They can also be triggered by environmental conditions or external stimuli, and their fluorescence is valuable for diagnostic purposes. The article also examines the toxicity of CQDs and their compatibility with larger nanoparticle carriers. The future of CQDs in theragnostic applications looks promising due to their multifunctional attributes and biocompatibility.
Article
Environmental Sciences
Ji-Eun Kim, Myung-Haing Cho
Summary: In this study, the effects of two types of multiwall carbon nanotubes (MWCNTs) on the kidneys and aging were compared. It was found that pristine MWCNTs could induce inflammation, apoptosis, insufficient autophagy, and premature kidney aging, with decreased Klotho levels and increased levels of DKK-1, FGF-23, and sclerostin in the serum. This study suggests that using MWCNTs in the industrial field may have toxic effects on the kidneys, and the dispersibility of the nanotubes can affect their toxicity.
Article
Agriculture, Multidisciplinary
Paula S. Ferreira, John A. Manthey, Marina S. Nery, Thais B. Cesar
Summary: The study demonstrated the metabolism and distribution of orally administered eriocitrin in rats for the first time, identifying multiple metabolites in rat urine and tissues, with homoeriodictyol and homoeriodictyol-7-O-glucuronide as the major metabolites. The half-lives of metabolites in plasma were approximately 3 to 3.2 hours, and the total bioavailability of eriocitrin was less than 1%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Physical
Yanhua Peng, Guansheng Xie, Penghui Shao, Wei Ren, Mengling Li, Yufeng Hu, Liming Yang, Hui Shi, Xubiao Luo
Summary: This study compares the oxidation differences of sulfamethoxazole (SMX) by carbon nanotube (CNT)/peroxymonosulfate (PMS), nanodiamond (ND)/PMS, and PMS direct oxidation systems. The results showed that the reaction rate constant of the CNT/PMS system is significantly higher than the ND/PMS and PMS direct oxidation systems. Product analysis revealed differences in the oxidation mechanism and products among the different oxidation systems. Therefore, the choice of carbon catalyst plays a crucial role in the degradation and toxicity of organic pollutants in wastewater treatment.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Chemistry, Multidisciplinary
Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonniere, Xavier Pivot, Alexandre Detappe
Summary: Tumor-targeted antibody/fragment-conjugated nanoparticles show promise in improving local delivery of small molecules. A meta-analysis of 161 studies confirmed that targeted nanoparticles had significantly higher tumor uptake compared to naked nanoparticles. The study also found that the choice of nanoparticle type, size, and antibody moiety affected tumor uptake.
ADVANCED MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Alexey V. Yaremenko, Ivan V. Zelepukin, Ilya N. Ivanov, Roman O. Melikov, Nadezhda A. Pechnikova, Dzhuliia Sh. Dzhalilova, Aziz B. Mirkasymov, Vera A. Bragina, Maxim P. Nikitin, Sergey M. Deyev, Petr I. Nikitin
Summary: This study observed the complete lifecycle of 40-nm magnetic particles in vivo and analyzed their impact on the organism. The nanoparticles were eliminated from the bloodstream in 2 hours, but their initial biodistribution changed over time. After 1 week, a major part of the nanoparticles was transferred to the liver and spleen, where they degraded with a half-life of 21 days. MRI and a magnetic spectral approach revealed that the contrast in these organs was preserved for over 1 month. The degradation of the particles led to an increase in the number of red blood cells and blood hemoglobin level without causing toxicity in tissues.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Arianna Dalla Colletta, Marco Pelin, Silvio Sosa, Laura Fusco, Maurizio Prato, Aurelia Tubaro
Summary: Carbon-based nanomaterials (CBNs) have been extensively studied for various applications due to their excellent physicochemical properties. However, there is a lack of toxicological data on their potential adverse effects at the skin level. Therefore, more research is needed to evaluate the safety of CBNs for skin applications.
Article
Chemistry, Multidisciplinary
Yuting Wen, Mei Zhang, Yangxue Yao, Yang Gao, Xiaolin Zhang, Yunfeng Lin, Xiaoxiao Cai
Summary: The hyperplasia and destruction of synovial tissue have a significant impact on the development of rheumatoid arthritis. Targeting anomalous synovial fibroblast and designing a high bioavailability nano drug delivery system can reduce the dosage for the treatment of rheumatoid arthritis and improve curative effect. The experiment established a nobiletin-loaded tetrahedral framework nucleic acids cargo tank which effectively alleviated the disease development of rheumatoid arthritis by reducing the invasiveness of pathological synovial fibroblast.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yangyang Wang, Weiqiang Jia, Jianwei Zhu, Ruxiang Xu, Yunfeng Lin
Summary: Cognitive impairment often occurs after post traumatic brain injury and its recovery depends on spontaneous repair and severity of secondary insult. Tetrahedral framework nucleic acid, a novel nanostructure, has been shown to promote regeneration and anti-inflammation. In this study, we established a mouse model of traumatic brain injury and confirmed the efficacy of tetrahedral framework nucleic acids in promoting cognitive impairment recovery. The results indicate that tetrahedral framework nucleic acids enhance the proliferation of endogenous neural stem cells and modulate neuroinflammatory response, suggesting their potential use in treating cognitive impairment after traumatic brain injury.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Tao Zhang, Huangshui Ma, Xiaolin Zhang, Sirong Shi, Yunfeng Lin
Summary: A tetrahedral DNA nanomaterial (TDN-TLR4-4siR) modified with Toll-like receptor 4 (TLR4) siRNA on each vertex successfully reversed the imbalance in polarization of M1 macrophages induced by Zoledronic Acid (ZA) treatment, reducing the proportion of M1 macrophages. TDN-TLR4-4siR also decreased intracellular ROS production and restored mitochondrial membrane potential. Additionally, the TDN-TLR4-4siR group exhibited decreased sequestra formation and accelerated healing of the extraction wound, resulting in a reduced incidence of rat BRONJ by reprogramming polarized macrophages. Therefore, this study establishes a novel strategy using TDN-TLR4-4siR nanomaterial to regulate mitochondrial homeostasis of polarized macrophages to prevent BRONJ.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yue Sun, Xingyu Chen, Sirong Shi, Taoran Tian, Zhiqiang Liu, En Luo, Yunfeng Lin
Summary: Antibiotic multiresistance (AMR) is a major threat to human health, causing millions of deaths annually. This study explores the use of tetrahedral framework nucleic acids (tFNAs) as drug delivery platforms to address the issue. The tFNAs-antibiotic compound (TAC) shows promising inhibitory effects on bacteria and improves the survival rate in mouse models of systemic peritonitis and local wound infections. The TAC not only enhances antibiotic absorption by bacteria but also regulates macrophage differentiation, potentially improving immunity and offering a new option for infection treatment.
Article
Cell Biology
Xiaodi Zhou, Yanting Lai, Xiaoxiao Xu, Qiong Wang, Limei Sun, Limei Chen, Jiajie Li, Rong Li, Delun Luo, Yunfeng Lin, Xiaoyan Ding
Summary: This study aimed to explore the effect and mechanism of tetrahedral framework nucleic acids (tFNAs) in inhibiting pathological retinal neovascularization (RNV) and vaso-obliteration (VO) in ischaemic retinopathy. Cell-based assays showed that tFNAs can enter endothelial cells (ECs) and inhibit angiogenic functions. In vivo experiments confirmed that tFNAs reduce RNV and inhibit VO through the PI3K/AKT/mTOR/S6K pathway. This study provides a theoretical basis for understanding RNV and suggests that tFNAs could be a novel candidate for treating blind-causing RNV.
CELL PROLIFERATION
(2023)
Article
Chemistry, Multidisciplinary
Yuxi Zhan, Yuxin Zhang, Chenchen Mao, Jiajie Li, Yuxuan Zhao, Ye Chen, Zhiqiang Liu, Yunfeng Lin
Summary: This article investigates a novel approach to modulate the tumor microenvironment using bacterial nanomaterials, which showed powerful anti-tumor effects both in vitro and in vivo experiments. It also suggests that this approach may have the potential to improve the functionality of the immune system.
Article
Nanoscience & Nanotechnology
Yuling Luo, Xiao Yang, Yue Du, Yikai Dou, Weitong Cui, Jiajie Li, Jinxue Wei, Xiaohong Ma, Yunfeng Lin
Summary: This study successfully used DNA tetrahedra as carriers of miR-22-3p and synthesized a novel DNA nanocomplex. The results suggest that miR-22-3p may regulate inflammation by regulating PTEN and downregulating NLRP3 expression. The use of TDN-miR-22-3p in an animal model of depression showed amelioration of depression-like behavior and attenuation of inflammation-related factors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xin Qin, Bowen Zhang, Xiaoqin Sun, Mei Zhang, Dexuan Xiao, Shiyu Lin, Zhiqiang Liu, Weitong Cui, Yunfeng Lin
Summary: In this study, a complex called T-155, consisting of a tetrahedral framework nucleic acid delivery system and MicroRNA-155, was synthesized as an immunomodulator for immunosuppression. The experimental results showed that T-155 could improve spleen and thymus damage and hematopoiesis suppression in immunosuppressed mice by promoting T-cell proliferation against oxidative stress. In vitro, T-155 induced the differentiation of immature dendritic cells into mature ones via the ERK1/2 pathway and converted M0 macrophages into M1 type to enhance antigen-presenting cells' surveillance capabilities. These findings suggest that T-155 has therapeutic potential as an immunomodulator for immunosuppression.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Taoran Tian, Chong Zhao, Songhang Li, Zhiyin Huang, Yangkun Guo, Wenting Dai, Ruqiang Bai, Chengwei Tang, Yunfeng Lin, Jinhang Gao
Summary: This study established a new strategy to attenuate liver fibrosis by using a C-C chemokine receptor 2 (CCR2) small interfering RNA silencing (siCcr2)-based therapy loaded with a tetrahedron framework DNA nanostructure (tFNA) vehicle (tFNA-siCcr2).
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ran Yan, Weitong Cui, Wenjuan Ma, Jiajie Li, Zhiqiang Liu, Yunfeng Lin
Summary: Acute kidney injury (AKI) is a global problem with high mortality rate and is also a risk factor for chronic kidney disease. This study developed a promising nanomedicine, tFNA-Typ complex (TTC), which can target mitochondria and renal tubule, and has enhanced antiapoptotic and antioxidative effects, as well as promoting mitochondria and kidney function restoration. This dual-targeted nanoparticle could have critical clinical applications for AKI treatment in the future.
Article
Engineering, Environmental
Mei Zhang, Yuting Wen, Zhangheng Huang, Xin Qin, Mi Zhou, Dexuan Xiao, Weitong Cui, Zhiqiang Liu, Yunfeng Lin
Summary: A novel nanomedicine was developed for the treatment of rheumatoid arthritis, which carries methotrexate and uses aptamer targeting tumor necrosis factor-alpha. This targeted nanomedicine accumulates in the inflammatory joints, reducing systemic toxicity and decreasing joint damage.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Wenjuan Ma, Yuting Yang, Zhiqiang Liu, Rui Zhao, Qianyi Wan, Xingyu Chen, Bicai Tang, Yong Zhou, Yunfeng Lin
Summary: Antibody drug conjugates (ADCs) show promise as mainstream chemotherapeutics for advanced HER2-positive cancers, but issues such as poor drug delivery efficiency, limited chemotherapeutic effects, severe immune responses, and drug resistance need to be addressed. DNA aptamer-guided drug conjugates (ApDCs) are attracting attention for their tumor affinity and low cost. Developing a multivalent ApDC nanomedicine, HApt-tFNA@Dxd, may help address these concerns.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pediatrics
Tian Tian, Tongjia Gan, Jun Chen, Jun Lu, Guiling Zhang, Yiran Zhou, Jia Li, Haoyue Shao, Yufei Liu, Hongquan Zhu, Di Wu, Chengcheng Jiang, Jianbo Shao, Jingjing Shi, Wenzhong Yang, Wenzhen Zhu
Summary: An intelligent HIE identification model (DLCRN) based on conventional structural MRI and clinical characteristics was developed and validated in this study. The DLCRN model showed good discrimination, calibration, and clinical applicability in diagnosing HIE. Visualization of the DLCRN highlighted the lesion areas that conformed to radiological identification. Scientific application of the optimized DLCRN model may save time for screening early mild HIE, improve the consistency of HIE diagnosis, and guide timely clinical management.
Article
Chemistry, Multidisciplinary
Geru Zhang, Liwei Huang, Maogeng Feng, Tianxu Zhang, Yang Gao, Yangxue Yao, Songhang Li, Xiaobing Li, Yunfeng Lin
Summary: Radiation-induced oral mucositis (RIOM) is a significant public health problem affecting patients who have received radiotherapy, but there is limited research on preventing and treating RIOM. This study developed a tetrahedral framework nucleic acid drug delivery system (TFNAS) to effectively deliver Curcumin (Cur-TFNAS). Results showed that Cur-TFNAS enhanced antioxidant capacity and reduced DNA damage in oral mucosal cells, indicating its potential as a nano-shield against radiation-induced oral mucositis.
Article
Chemistry, Multidisciplinary
Yueying Jiang, Songhang Li, Ruijianghan Shi, Wumeng Yin, Weitong Lv, Taoran Tian, Yunfeng Lin
Summary: Gene vectors and miR therapeutic strategies are research hotspots. By upgrading the traditional tFNA, a bioswitchable miR mimic delivery system (BiRDS) is designed to treat skin fibrosis. The results show that BiRDS has higher efficiency in delivering miRNAs and is more effective against fibrosis and pyroptosis-related diseases.
