Article
Chemistry, Multidisciplinary
Xintong Bian, Ningke Fan, Meng Li, Daobin Han, Jia Li, Lu Fan, Xinyu Li, Liangsheng Kong, Hua Tang, Shijia Ding, Fangzhou Song, Siqiao Li, Wei Cheng
Summary: A hepatocellular carcinoma (HCC) cell-derived ER vesicle (ER-horse) has been developed for precise HCC nanotherapy by imitating the physiological function of endoplasmic reticulum (ER) and triggering excessive ER stress and apoptosis. The findings provide a new method for HCC nanotherapy via interference of ER stress signaling.
Article
Pharmacology & Pharmacy
Larry Morgan, Monica Antenos, Gordon M. Kirby
Summary: The study found that DTTox and 2-mercaptoethanol can induce the expression of Cyp2a5 protein in mouse liver cells. In addition, DTTox transactivates Cyp2a5 by activating the transcription factor nuclear factor-(erythroid-derived 2)-like 2 (Nrf2). Overexpression of Cyp2a5 partially protects cells during reductive ER stress by reducing XBP-1 mRNA splicing and caspase-3 cleavage.
Article
Agriculture, Multidisciplinary
Jinye Huang, Manxin Bao, Jun Li, Hui Chen, Dongmei Xu, Zunwei Chen, Yuezhong Wen
Summary: This study investigates the role of trace element Fe and secondary metabolite DIMBOA in mediating the toxicity of chiral herbicides. The results show that the active enantiomer of the herbicide imazethapyr stimulates various responses in plants, including heme oxygenase-1 activity, release of Fe2+, reactive oxygen species production, and changes in DIMBOA content. Further analysis reveals that DIMBOA can chelate excessive Fe3+ to restore Fe homeostasis and relieve the phytotoxicity. This research provides new insights into improving herbicide resistance in crops.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Microbiology
Vincent Saillant, Damien Lipuma, Emeline Ostyn, Laetitia Joubert, Alain Boussac, Hugo Guerin, Geraldine Brandelet, Pascal Arnoux, Delphine Lechardeur
Summary: Enterococcus faecalis is a commensal Gram-positive pathogen found in the intestines of mammals and a leading cause of severe infections in hospitalized patients. The transcriptional regulator FhtR manages heme homeostasis in E. faecalis by controlling an efflux pump, thus regulating heme detoxification. The FhtR-HrtBAEf system is relevant in a mouse intestinal model, sensing heme fluctuations within the gastrointestinal tract.
Article
Microbiology
Carlos Tejeda, Pamela Steuer, Marcela Villegas, Fernando Ulloa, Jose M. Hernandez-Agudelo, Miguel Salgado
Summary: This study investigates the gene expression of Mycobacterium avium subsp. paratuberculosis (MAP) when exposed to copper ions, and found that genes associated with copper homeostasis trigger an adaptive response in MAP.
Article
Biochemistry & Molecular Biology
Arash Ghorbannia, Mehdi Maadooliat, Ronald K. K. Woods, Said H. H. Audi, Brandon J. J. Tefft, Claudio Chiastra, El Sayed H. Ibrahim, John F. F. LaDisa
Summary: This study successfully established a growth and remodeling (G & R) model based on empirical measurements from a rabbit model of CoA, which can predict the arterial changes leading to hypertension precursors. The predicted results from the model were found to be in excellent agreement with the observed patterns. This research provides a validated computational tool for predicting persistent arterial dysfunction and identifying revised severity-duration thresholds for CoA.
Article
Environmental Sciences
M. Nasir Khan, Manzer H. Siddiqui, Khalaf M. Alhussaen, Alaa Rafat El-Alosey, Meshari Atallah M. AlOmrani, Hazem M. Kalaji
Summary: This study investigated the response of cucumber seedlings to drought and nickel stress, and found that application of nano titanium dioxide (nTiO2) improved their antioxidant and metabolic activities, enhancing their resistance to drought and nickel stress.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell Biology
Won Hoon Choi, Yejin Yun, Insuk Byun, Sumin Kim, Seho Lee, Jiho Sim, Shahar Levi, Seo Hyeong Park, Jeongmoo Jun, Oded Kleifeld, Kwang Pyo Kim, Dohyun Han, Tomoki Chiba, Chaok Seok, Yong Tae Kwon, Michael H. Glickman, Min Jae Lee
Summary: It is found that glucose starvation can dissociate 26S proteasomes into 20S and 19S subcomplexes. ECPAS is shown to mediate this structural remodeling process. Loss of ECPAS reduces 26S dissociation and leads to decreased degradation of 20S proteasome substrates.
Article
Engineering, Environmental
Huanliang Liu, Yu Wu, Zhenyu Wang
Summary: This study found that the heme homeostasis signal participates in inducing a protective response when controlling nanopolystyrene toxic effects in the parental generation. However, its role in the regulation of transgenerational toxicity of nanopolystyrene toxicity is unclear. Using Caenorhabditis elegans as a model organism, it was discovered that nanopolystyrene particles downregulated the glb-18 gene expression in both the parental generation and the offspring. Lower levels of GLB-18 led to increased susceptibility to transgenerational toxicity of nanopolystyrene. Importantly, germline GLB-18 activated the downstream intestinal HRG-4/HRG-1/ATFS-1/HSP-6 pathway to control the transgenerational toxicity of nanopolystyrene. These findings suggest a possible association between changes in heme homeostasis signal and transgenerational nanoplastic toxicity within organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Oncology
Jinjing Xu, Kuiyang Zhu, Yali Wang, Jing Chen
Summary: This review summarizes the dual role of the heme/HO-1/Bach1 axis and their mutual dependence in carcinogenesis and anti-carcinogenesis intersection.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyewon Jang, Jiyeon Ham, Jisoo Song, Gwonhwa Song, Whasun Lim
Summary: Alpinumisoflavone is a natural compound with beneficial properties such as antioxidant, anti-inflammatory, antibacterial, osteoprotective, and neuroprotective effects. This study demonstrates the anti-cancer effects of alpinumisoflavone on hepatocellular carcinoma (HCC), showing its inhibition on cell viability, regulation of the MAPK/PI3K pathway, depolarization of mitochondrial membrane potential, suppression of mitochondrial respiration, dysregulation of mitochondrial complexes, accumulation of calcium ions in the mitochondria, and induction of mitochondria-mediated apoptosis.
Article
Environmental Sciences
Huanliang Liu, Yingyue Zhao, Kun Bi, Qi Rui, Dayong Wang
Summary: Our study reveals that neuronal miRNA mir-76 controls nanoplastic toxicity in nematodes by regulating the globin protein GLB-10 in neurons. Moreover, we identified a signaling cascade involving HRG-7 and HRG-5 that is crucial for regulating heme homeostasis and NPS toxicity in organisms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Na Li, Zhihuan Zhang, Zijing Chen, Bili Cao, Kun Xu
Summary: Salt is a critical factor affecting plant yield and quality. This study found that 100 mmol L-1 NaCl was the most suitable treatment concentration for Chinese cabbage cultivars, and identified fresh weight and electrolyte leakage in leaves as convenient indicators for salt tolerance. Physiological responses and transcriptome dynamics analyses showed that salt-tolerant Qinghua45 could maintain ion homeostasis and photosynthesis under salt stress, with fewer differentially expressed genes compared to salt-sensitive Biyuchunhua. Genes such as VDAC, Cation/H (+) antiporter 17, and V-H + -ATPase were identified to play roles in salt tolerance mechanisms.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Endocrinology & Metabolism
Yong Zhou, Yang Jin, Yuan Wang, Ruijin Wu
Summary: Endometriosis is a chronic gynecological disease with an unclear cause. Hypoxia is closely related to the occurrence and development of the disease, with hypoxia-inducible factor-1 alpha playing a key role and the unfolded protein response supplementing cell survival under hypoxic stress.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Hematology
Chen Zhang, Yanming Li, Abhijit Chakraborty, Yang Li, Kimberly R. Rebello, Pingping Ren, Wei Luo, Lin Zhang, Hong S. Lu, Lisa A. Cassis, Joseph S. Coselli, Alan Daugherty, Scott A. LeMaire, Ying H. Shen
Summary: This study reveals that aortic cells adapt to stress by modifying their functions, leading to a protective adaptive response against aortic aneurysm and dissection (AAD). The adaptive response involves upregulation of genes related to wound healing, elastin and collagen production, proliferation, migration, cytoskeleton organization, cell-matrix focal adhesion, and PI3K-PKB/Akt and TGF-beta signaling. YAP is identified as an important transcription complex driving the expression of these genes and plays a role in mechanical signal transduction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
