Review
Biochemistry & Molecular Biology
Clement G. G. Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson, Bryan Mildort, Lekan Latinwo, Paul B. B. Tchounwou
Summary: Diabetes mellitus (DM) is a chronic metabolic disease associated with high blood sugar levels and various complications. Medicinal plants and vitamins have shown potential in the prevention and treatment of DM. This review article aims to study DM and explore the therapeutic modalities based on medicinal plants and vitamins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Rosario Suarez, Sebastian P. Chapela, Ludwig Alvarez-Cordova, Estefania Bautista-Valarezo, Yoredy Sarmiento-Andrade, Ludovica Verde, Evelyn Frias-Toral, Gerardo Sarno
Summary: A long-term complication of obesity is the development of type 2 diabetes (T2D), which involves epigenetic modifications. Epigenetics refers to post-transcriptional modifications of DNA or associated factors that influence gene expression. The epigenetic modifications involved in T2D include DNA methylation, acetylation, ubiquitylation, SUMOylation, and phosphorylation. These modifications have been observed in various tissues and are also found in chronic complications of T2D. A new drug, apabetalone, which targets epigenetic readers, is being studied as a potential treatment for T2D and its cardiovascular complications.
Review
Biochemistry & Molecular Biology
Yahia A. Kaabi
Summary: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia. Inflammation plays a crucial role in the pathogenesis of various microvascular complications of diabetes, including diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy. This review summarizes the evidence and molecular mechanisms of inflammation in these complications, as well as discusses the potential therapeutic use of bioactive compounds derived from plants.
Review
Endocrinology & Metabolism
Xinyang Guo, Yiqiao Xing, Wei Jin
Summary: Diabetic microangiopathy is a common and severe problem in diabetics, and it includes diabetic retinopathy, nephropathy, neuropathy, and cardiomyopathy. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is significantly elevated in patients with type 2 diabetes and microvascular complications. ADMA promotes the occurrence and progression of microvascular complications in type 2 diabetes through influencing endothelial cell function, oxidative stress damage, inflammation, and fibrosis. This review paper explores the association between ADMA and microvascular complications of diabetes, and provides new insights and potential treatment options.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manjiri P. P. Jalgaonkar, Urvi M. M. Parmar, Yogesh A. A. Kulkarni, Manisha J. J. Oza
Summary: The prevalence of diabetes is increasing, leading to microvascular and macrovascular complications. The interaction between SIRT1 and FOXOs plays an important role in controlling and alleviating diabetic complications, suggesting them as potential therapeutic targets.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Sung Keun Park, Min-Ho Kim, Ju Young Jung, Chang-Mo Oh, Eunhee Ha, Do Jin Nam, Eun Hye Yang, Woo Yeon Hwang, Sangho Lee, Jae-Hong Ryoo
Summary: Long-term and heavy smoking increases the risk of microvascular complications, including nephropathy and neuropathy, in patients with diabetes mellitus. Quitting smoking and reducing smoking amount are crucial in preventing microvascular complications in diabetic patients.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Spectroscopy
Priyanka A. Jadhav, Arti Hole, M. Sivaprasad, K. Viswanath, Manisha Sahay, Rakesh Sahay, G. Bhanuprakash Reddy, C. Murali Krishna
Summary: Diabetes is a major global public health challenge, and its complications pose high risks to patients. This study used Raman Spectroscopy to analyze plasma samples from diabetes patients and found a decrease in protein content. The classification accuracy of Raman spectra was lower in the diabetes and complications groups, but a small number of complications samples were misclassified as control group. These findings suggest that Raman Spectroscopy may be useful for early detection or diagnosis of diabetic complications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Medicine, General & Internal
Wei-Jing Zhao, Xin-Yi Xia, Jun Yin
Summary: The study found that vitamin D deficiency is independently associated with a higher risk of DPN and DN in T2DM patients, but not DR. Additionally, vitamin D deficiency may serve as a potential predictor for both the occurrence and severity of DPN and DN.
CHINESE MEDICAL JOURNAL
(2021)
Review
Chemistry, Medicinal
Lina T. Al Kury
Summary: Hyperglycemia, a hallmark of diabetes, can lead to various health complications. Medicinal plants offer bioactive compounds with pharmacological effects and fewer side effects. This review focuses on their modulation of the pancreatic K-ATP channel and emphasizes the importance of studying their interaction for diabetes treatment.
Article
Chemistry, Multidisciplinary
Abraham Madariaga-Mazon, Jose J. Naveja, Jose L. Medina-Franco, Karla O. Noriega-Colima, Karina Martinez-Mayorga
Summary: Natural products, especially from medicinal plants, are important sources of bioactive compounds, including those with potential antidiabetic properties. Despite the abundance of research articles on antidiabetic compounds, the lack of a chemical database hampers their application in drug development.
Article
Medicine, General & Internal
Mohammad Dweib, Nuha El Sharif
Summary: This study investigated the factors associated with diabetes-related microvascular complications among individuals with diabetes in the West Bank of Palestine. The results showed that age, education level, residency location, and adherence to diabetes management guidelines were all associated with the occurrence of microvascular complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Physiology
Nihal Satyadev, Milagros I. Rivera, Nicole K. Nikolov, Adegbenro O. J. Fakoya
Summary: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder. Exosomes, small extracellular vesicles released by cells, have been identified as important contributors to the pathogenesis of T2DM and its complications. This review explores the potential of exosomes as biomarkers and therapeutic targets for T2DM and discusses their role in various complications.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Yan-Li Gou, Ya-Pu Zhang, Yang Xu, Jian-Dong Li, Yang Huang, Hang Chen
Summary: This article discusses a case of a diabetes patient with IgAN, highlighting the possibility of using renal biopsy to definitively diagnose DKD, NDKD, or a combination of both, as well as the potential of precise therapy based on renal pathology to improve kidney outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Gulali Aktas
Summary: The prognostic nutritional index (PNI) is associated with inflammatory conditions and can be used to evaluate the inflammatory burden in patients with type 2 diabetes mellitus (T2DM). This study found that the PNI levels were lower in T2DM patients compared to healthy individuals, and even lower in T2DM patients with microvascular complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Merlin L. Willcox, Christina Elugbaju, Marwah Al-Anbaki, Mark Lown, Bertrand Graz
Summary: Several medicinal plants have shown to be effective in reducing HbA1c in patients with Type 2 Diabetes, with some showing effects comparable to conventional antidiabetic treatments. Rigorous trials with at least 3 months' follow-up are required to evaluate the effects of promising plant-based preparations on diabetes.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Toxicology
Khojasteh Malekmohammad, Mahmoud Rafieian-Kopaei, Samira Sardari, Robert D. E. Sewell
Summary: Peppermint, commonly used as a medicinal plant and flavoring agent, has moderate toxicity. It is contraindicated in patients with bile duct obstruction or gall bladder inflammation, and caution should be exercised in patients with gastrointestinal reflux or hiatus hernia.
Review
Chemistry, Medicinal
Kamal Solati, Mehrdad Karimi, Mahmoud Rafieian-Kopaei, Naser Abbasi, Saber Abbaszadeh, Mahmoud Bahmani
Summary: This article explores the use of Iranian medicinal plants and herbal compounds for wound healing, identifying 139 effective plants based on ethnopharmacology and ethnobotanical sources of Iran. Plants such as Salvia officinalis and Aloe vera are highlighted as important contributors to wound healing in Iran, offering potential for the development of new drugs.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Elahe Aleebrahim-Dehkordi, Niloofar Deravi, Shirin Yaghoobpoor, Dariush Hooshyar, Mahmoud Rafieian-Kopaei
Summary: Vitamin D plays an important role in immunity and recovery from viral infections, especially COVID-19. It can enhance cellular immunity, reduce cytokine storm, and potentially provide protection against acute lung injuries. However, vitamin D deficiency should not be considered a specific risk factor for COVID-19 infection.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pharmacology & Pharmacy
Khojasteh Malekmohammad, Mahmoud Rafieian-Kopaei
Summary: This study reviewed the mechanism of action of plants and plant compounds against SARS-CoV-2, and their inhibitory effects on important viral proteins, including Spike protein, PLpro, and 3CLpro. Some medicinal plants and their metabolites with anti-SARS-CoV-2 actions intervene in virus replication and entry through various pathways, potentially valuable for preventing and treating symptoms related to COVID-19.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pharmacology & Pharmacy
Farzad Koosha, Niloufar Alimohammadi, Mahmoud Rafeian-Kopaei
Summary: Extracellular vesicles, also known as exosomes, are small membrane-bound particles that play a significant role in cellular communication by transporting various molecules. Their potential in diagnosing and treating cardiovascular diseases has a bright future, offering new possibilities in cardiology medicine. They can serve as valuable biomarkers and natural drug-delivery vehicles for targeted treatments in myocardial injury and repair.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Integrative & Complementary Medicine
Nayereh Bahamin, Shahin Ahmadian, Mahmoud Rafieian-Kopaei, Gholamreza Mobini, Mahshid Shafiezadeh, Amin Soltani
Summary: This study demonstrates that the combination of Alhagi maurorum and Amygdalus haussknechtii with docetaxel has synergistic antitumor effects on 4T1 breast cancer cells, inducing apoptosis and regulating gene expression of HIF-1alpha and FZD7. Amygdalus haussknechtii has acceptable antitumor activity but shows limited efficacy in combination with docetaxel.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Food Science & Technology
Maryam Heidari, Morteza Khomeiri, Hossein Yousefi, Mahmoud Rafieian, Mahboobeh Kashiri
Summary: The study focused on fabricating and characterizing ChNF-based nanocomposites with biodegradable polymers, such as thermoplastic starch, gelatin, and poly(vinyl alcohol). Mixing ChNF with polymers resulted in more homogeneous surfaces and improved crystalline properties. The nanocomposite films showed increased water vapor permeability compared to pure ChNF film, with varying water solubility values. Incorporating thermoplastic starch, gelatin, and poly(vinyl alcohol) led to enhanced physical and mechanical properties in the nanocomposites, making them potential materials for biodegradable and edible food packaging.
JOURNAL OF CONSUMER PROTECTION AND FOOD SAFETY
(2021)
Article
Pharmacology & Pharmacy
Mehrnoosh Sedighi, Vajihe Ghorbanzadeh, Saber Abaszadeh, Arash Karimi, Mostafa Cheraghi, Mahmoud Rafieian-Kopaei, Maryam Moghimian, Asghar Mohammadi, Saeid Veiskarami, Yaser Mokhayeri, Afshin Nazari
Summary: The study found that Cichorium intybus can improve infarct size, episodes of ventricular ectopic beats, ventricular tachycardia, duration of ventricular tachycardia, and shorten QTc. It also stabilizes ST segment changes and increases heart rate during ischemia. Compared to the control and CI-200 group, blood pressure decreased in the CI-50 group. C. intybus increased serum superoxide dismutase, reduced lactate dehydrogenase activity, cardiac troponin I, and malondialdehyde levels. C. intybus also led to an increase in the expression of chemokine receptor type 4.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Samira Sanami, Fatemeh Azadegan-Dehkordi, Mahmoud Rafieian-Kopaei, Majid Salehi, Maryam Ghasemi-Dehnoo, Mehran Mahooti, Morteza Alizadeh, Nader Bagheri
Summary: This study aimed to design a therapeutic vaccine against cervical cancer using reverse vaccinology, selecting E6 and E7 oncoproteins from HPV16 as target antigens for epitope prediction and constructing a multi-epitope vaccine with appropriate adjuvants. The physicochemical properties, antigenicity, and allergenicity of the vaccine construct were evaluated, and further analyses including molecular docking, MD simulation, and in silico cloning were performed. Results suggested the proposed vaccine could be effective, but further in vitro and in vivo experiments are needed for validation.
SCIENTIFIC REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Khojasteh Malekmohammad, Evgeny E. Bezsonov, Mahmoud Rafieian-Kopaei
Summary: Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation, especially low-density lipoprotein, and dysfunction of lipid homeostasis. Inflammation plays a key role in all phases of atherosclerosis, while lipid metabolism and inflammatory pathways interact closely with each other. Studies have shown that microRNAs and lncRNAs also have important regulatory roles in the pathophysiology of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Energy & Fuels
Farideh Zandi-Darehgharibi, Hedayat Haddadi, Mahmoud Rafieian-Kopaei, Aziz A. Fallah
Summary: This study evaluated the antioxidative activity of pistachio green hull (PGH) as a potential natural antioxidant. The results showed that the isolated polyphenolic fraction of PGH had significant inhibitory effects on oil oxidation.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Sport Sciences
Sara Torkamaneh, Angel Saez-Berlanga, Fernando Martin, Pedro Gargallo, Jorge Flandez, Javier Gene-Morales, Mohmoud Rafieian-Kopaei, Juan C. Colado
Summary: The study aimed to investigate the effects of resistance or aerobic exercise combined with Cornus mas extract on lipid profile, metabolic parameters, and liver enzymes in obese rats. Results showed significant improvements in most parameters in the intervention groups compared to the hypercaloric group, with potentially beneficial effects in treating fatty liver and reducing lipid levels.
JOURNAL OF HUMAN SPORT AND EXERCISE
(2021)
Article
Sport Sciences
Sara Torkamaneh, Javier Gene-Morales, Jorge Flandez, Mahendra Yadac, Mohammad Sidiq, Mohmoud Rafieian-Kopaei, Juan C. Colado
Summary: Aerobic exercise combined with garlic and lemon juice intake may have a positive impact on lipid profile, liver enzymes, and other blood parameters related to cardiovascular disease, showing slightly non-significant better results compared to other interventions.
JOURNAL OF HUMAN SPORT AND EXERCISE
(2021)
Article
Sport Sciences
Sara Torkamaneh, Javier Gene-Morales, Alvaro Juesas, Jorge Flandez, Raouf Hammami, Mohmoud Rafieian-Kopaei, Juan C. Colado
Summary: The study demonstrated that the intake of Berberis vulgaris L combined with aerobic or resistance exercise significantly improved lipid profile, metabolic parameters, and liver enzymes in obese male rats, suggesting its potential for preventing cardiovascular disease.
JOURNAL OF HUMAN SPORT AND EXERCISE
(2021)
Article
Surgery
Golnoush Kouhihabibidehkordi, Soleiman Kheiri, Iraj Karimi, Fatemeh Taheri, Elham Bijad, Mohammad Bahadoram, Zahra Alibabaie, Shirin Asgharian, Hajar Zamani, Mahmoud Rafieian-Kopaei
Summary: The study found that five percent white tea extract did not help with the skin wound healing process.
WORLD JOURNAL OF PLASTIC SURGERY
(2021)
