Journal
CURRENT DIABETES REPORTS
Volume 12, Issue 3, Pages 274-279Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-012-0265-8
Keywords
Diabetes mellitus; Cardiovascular risk; Haptoglobin genotype; Vitamin E
Categories
Funding
- Israeli Science Foundation
- National Institutes of Health (NIH) [RO1DK085226]
Ask authors/readers for more resources
Diabetes mellitus (DM) carries an increased risk for cardiovascular complications. Haptoglobin (Hp) is an abundant plasma protein with an antioxidant function by virtue of its ability to block the oxidative activity of extracorpuscular hemoglobin. There exist two common functional alleles at the Hp genetic locus, denoted 1 and 2, with three Hp genotypes (Hp 1-1, 2-1, and 2-2). The Hp protein expressed in Hp 2-2 individuals is markedly inferior in protecting against hemoglobin-induced oxidative stress. Hp 2-2 DM individuals have been shown to be at increased risk for the development of diabetes complications, particularly diabetic cardiovascular disease (CVD). We review the biological mechanisms underlying the interaction between the Hp genotype and DM on CVD and the accumulating evidence in favor of Hp genotyping all individuals with DM and providing antioxidant vitamin E supplementation specifically to Hp 2-2 DM individuals to reduce their CVD morbidity and mortality.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available