Editorial Material
Plant Sciences
Lena Vlaminck, Birgit Vanden Berghen, Liesbet Vranken, Sofie Goormachtig
Summary: Citizen science is an underappreciated tool that can enhance both fundamental and applied science by going beyond basic data collection. We advocate for the integration of these three disciplines to promote sustainable and adaptive agriculture, using Northwestern European soybean cultivation as a case study.
TRENDS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dimitrios Matthaios, Maria Tolia, Davide Mauri, Konstantinos Kamposioras, Michalis Karamouzis
Summary: The YAP and Hippo pathway play crucial roles in immune system and cancer, with effects such as modulating immune response, enhancing tumor microenvironment, and regulating immune suppression, suggesting their potential applications in cancer immunotherapy.
Review
Immunology
Mohammad Hossein Kazemi, Maryam Sadri, Alireza Najafi, Ali Rahimi, Zeinab Baghernejadan, Hossein Khorramdelazad, Reza Falak
Summary: Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are recruited into the tumor site to fight against tumors. However, their small number and reduced activity limit their ability to overcome the tumor. Recent advances in understanding TME, immune exhaustion, and immune checkpoints have paved the way for TIL therapy regimens. Nowadays, TIL therapy has regained attention as a safe personalized immunotherapy, but it still faces challenges such as high cost and technical difficulties.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alessandra Murabito, Janki Bhatt, Alessandra Ghigo
Summary: In the last fifteen years, the approval of the first molecular treatments has marked a breakthrough era for cystic fibrosis (CF) patients. The use of CFTR modulators has significantly improved lung function and quality of life for most CF patients. However, the efficacy of these drugs is still not optimal and the response varies among individuals with the same mutation. Therefore, there is a need to explore alternative approaches, such as modulating the cAMP signaling pathway, for therapeutic intervention in CF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Frazer A. Cook, Simon J. Cook
Summary: The discussion in the article revolves around mutations in RAS and BRAF proteins in cancer, as well as the mechanisms of action of small molecule kinase inhibitors. The current issue is that in RAS-mutant cells, certain inhibitors can promote RAS-dependent dimerization and paradoxical activation of wild-type RAF.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Raika Pancaroglu, Filip Van Petegem
Summary: In this issue of Structure, Melville and colleagues used cryo-EM to study the binding of ryanodine receptors to Rycals, compounds with the potential to treat skeletal and cardiac muscle disorders. Unexpectedly, they found that Rycal packs against an ATP in a peripheral pocket, which stabilizes the closed channel state.
Editorial Material
Biochemistry & Molecular Biology
Tineke Vanderhaeghen, Jolien Vandewalle, Claude Libert
Summary: Sepsis is a life-threatening response to infection, causing high morbidity and mortality in intensive care units worldwide. Current management of sepsis is supportive, and there is an urgent need for new therapeutic interventions. This study shows that the transporter SPNS2 plays a crucial role in metabolic reprogramming of macrophages during sepsis, regulating inflammation through the lactate-ROS axis.
Article
Business, Finance
Guohao Tang, Fuwei Jiang, Xinlin Qi, Nan Huang
Summary: This paper proposes a fundamental timing strategy for both the U.S. and Chinese stock markets to select fundamentals sorted portfolios in the time-series dimension, achieving substantial performance gains relative to buy-and-hold strategies, particularly among firms with high idiosyncratic volatility and high illiquidity.
INTERNATIONAL JOURNAL OF FINANCE & ECONOMICS
(2021)
Article
Endocrinology & Metabolism
Leonard Girnita, Terry J. Smith, Joseph A. M. J. L. Janssen
Summary: This article reviews the generation of autoantibodies in thyroid eye disease (TED) and their direct effects on orbital fibroblast responses through the TSH receptor (TSHR), IGF-I receptor (IGF-IR), or both. Evidence suggests that IGF-IR functions not only as a typical tyrosine kinase receptor, but also as a functional receptor tyrosine kinase/G-protein-coupled receptor hybrid. Teprotumumab, a monoclonal IGF-IR antibody, effectively reduces TED disease activity and its in vitro actions on fibrocytes and orbital fibroblasts. The article proposes four possible IGF-IR activation models underlying the clinical responses to teprotumumab in TED patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Chemistry, Multidisciplinary
Maeva Coste, Esteban Suarez-Picado, Sebastien Ulrich
Summary: Supramolecular polymers are self-assembled materials displaying adaptive and responsive life-like behavior, often made of aromatic compounds engaging in pi-pi interactions. Recent advances have been made in controlling their self-assembly from thermodynamically-controlled isodesmic to kinetically-controlled living polymerization. Dynamic covalent chemistry has been utilized to generate dynamic covalent polymers, acting as dynamic analogues of biomacromolecules.
Review
Immunology
Manmohan Kumar, Shagun Sharma, Shibnath Mazumder
Summary: The immune system of a host utilizes different metabolic programs of immune cells to combat bacterial infection, while bacterial pathogens manipulate mitochondrial structure and functions to evade host immunity. Mitochondrial unfolded protein response (UPRmt) and mitochondrial dynamics play critical roles in mitochondrial adaptation to bacterial stress. This review highlights the immune functions of mitochondria against bacterial infection, focusing on the mechanisms of UPRmt and mitochondrial dynamics and their involvement in host immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Computer Science, Information Systems
Stefan Klotz, Markus Westner, Susanne Strahringer
Summary: This study identifies bilateral responsibility between business unit and IT organization as the most favorable governance option for Business-managed IT, and also highlights four groups of critical success factors.
INFORMATION SYSTEMS MANAGEMENT
(2022)
Article
Polymer Science
Yin Yam Chan, Bernhard Schartel
Summary: This feature article focuses on one of the most impressive halogen-free combinations in polyurethane foams (PUFs): expandable graphite (EG) and phosphorus-based flame retardants (P-FRs). The synergistic effect of EG and P-FRs improves the flame retardancy of PUFs by charring and maintaining a thermally insulating residue morphology, offering significant advantages.
Article
Biochemistry & Molecular Biology
Ulrik Gether, Harald H. Sitte
Summary: The dopamine transporter utilizes the transmembrane sodium gradient to mediate dopamine reuptake and can form dimers and potentially higher order structures. While the biological importance of this oligomerization is still not fully understood, a study by Sorkina et al. has provided insight into the link between transporter conformation, oligomerization, and endocytosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Business
Desiree A. Laubengaier, Raffaella Cagliano, Filomena Canterino
Summary: Industry 4.0 brings fundamental changes to company processes, where both technological and administrative process innovations are important and interact with each other in complex ways. This study highlights the significance of work design, people management, and strategy for Industry 4.0 initiatives.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2022)
Article
Multidisciplinary Sciences
Luis O. Romero, Andrew E. Massey, Alejandro D. Mata-Daboin, Francisco J. Sierra-Valdez, Subhash C. Chauhan, Julio F. Cordero-Morales, Valeria Vasquez
NATURE COMMUNICATIONS
(2019)
Article
Biology
Chih-Chieh (Jay) Yu, Nicholas C. Barry, Asmamaw T. Wassie, Anubhav Sinha, Abhishek Bhattacharya, Shoh Asano, Chi Zhang, Fei Chen, Oliver Hobert, Miriam B. Goodman, Gal Haspel, Edward S. Boyden
Article
Cell Biology
Adam L. Nekimken, Beth L. Pruitt, Miriam B. Goodman
MOLECULAR BIOLOGY OF THE CELL
(2020)
Correction
Multidisciplinary Sciences
Luis O. Romero, Rebeca Caires, Alec R. Nickolls, Alexander T. Chesler, Julio F. Cordero-Morales, Valeria Vasquez
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Luis O. Romero, Rebeca Caires, Alec R. Nickolls, Alexander T. Chesler, Julio F. Cordero-Morales, Valeria Vasquez
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Rebeca Caires, Briar Bell, Jungsoo Lee, Luis O. Romero, Valeria Vasquez, Julio F. Cordero-Morales
Summary: Research demonstrates that TRPV1 activity is enhanced when phosphoinositide lipid content is reduced, and the C-terminal domain is crucial in determining agonist response in vivo.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Physiology
Sylvia Fechner, Isabel D'Alessandro, Lingxin Wang, Calvin Tower, Li Tao, Miriam B. Goodman
Summary: DEG/ENaC/ASIC channels play crucial roles in sensing mechanical stimuli, regulating salt homeostasis, and responding to acidification in the nervous system. Studies have revealed that these channels vary among different family members, with differences not only in their ability to form channels but also in drug sensitivity. This suggests that not all DEG/ENaC/ASIC channels are amiloride-sensitive, and NSAIDs can both inhibit and potentiate these channels.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Editorial Material
Anatomy & Morphology
Miriam B. Goodman, Cathy Savage-Dunn
Summary: Studying TGF-beta signaling and the extracellular matrix in C. elegans has revealed unexpected connections between signaling and ECM, providing new insights into the interactions across tissues and spatial scales.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Chemistry, Physical
Claire A. McLellan, Chris Siefe, Jason R. Casar, Chunte Sam Peng, Stefan Fischer, Alice Lay, Abhinav Parakh, Feng Ke, X. Wendy Gu, Wendy Mao, Steven Chu, Miriam B. Goodman, Jennifer A. Dionne
Summary: This Letter reports the development of mechano-sensing upconverting nanoparticles (UCNPs) based on lanthanide dopants, which exhibit ratiometric change in emission spectra and bright emission under applied pressure. The authors synthesized and analyzed five different types of nanoparticles and determined their noise equivalent sensitivity using optical spectroscopy and single-particle brightness.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Biophysics
Lucy M. Wang, Miriam B. Goodman, Ellen Kuhl
Summary: Head injury simulations predict traumatic brain injury by setting a threshold on calculated strains for axon tracts. However, accurately predicting injuries is hindered by the choice of an appropriate axon damage threshold. We propose a new image analysis pipeline to reconstruct the microtubule geometry of axons, which reveals the heterogeneity that significantly affects deformation and argues for considering microtubule geometry heterogeneity in determining accurate failure thresholds.
BIOPHYSICAL JOURNAL
(2023)
Review
Physiology
Miriam B. Goodman, Elizabeth S. Haswell, Valeria Vasquez
Summary: This viewpoint discusses the unified and unique features of established and emerging mechanosensitive (MS) membrane proteins and the challenges in studying these important proteins and their partners. It also explores the diversity of known MS membrane proteins and the potential for new discoveries in this field. The viewpoint provides insights into the phylogenetic, structural, and functional aspects of membrane mechanosensors and highlights recent successes and ongoing challenges in studying them in various systems.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Meeting Abstract
Biophysics
Ehsan Rezaeil, Cathy Savage-Dunn, Miriam B. Goodman
BIOPHYSICAL JOURNAL
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Claire A. McLellan, Chris P. Siefe, Stefan Fischer, Jason R. Casar, Dayne F. Swearer, Miriam B. Goodman, Jennifer A. Dionne
2020 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2020)
Article
Area Studies
Jennifer K. O'Leary, Maurice Goodman, Arthur Tuda, Milali Machumu, Lindsey West
JOURNAL OF THE INDIAN OCEAN REGION
(2020)
